Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential

Journal of Autoimmunity

Volumn 33, Issue 3-4, 2009, Pages 270-274

  Zhang, Jie ^a   Jacobi, Annett M ^a   Wang, Tao ^a   Berlin, RoseAnn ^b   Volpe, Bruce T ^b   Diamond, Betty ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Autoantibodies; Ig class switching; Pathogenicity; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M;

ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL POPULATION; CROSS REACTION; GLOMERULUS; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOLOGICAL TOLERANCE; MICROARRAY ANALYSIS; NEUROTOXICITY; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RETINOPATHY; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; DNA; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL;

EID: 70350601075     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2009.03.011     Document Type: Article

References (17)

1. Yurasov S., Wardemann H., Hammersen J., Tsuiji M., Meffre E., Pascual V., et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 201 5 (2005) 703-711
2. Briere F., Servet-Delprat C., Bridon J.M., Saint-Remy J.M., and Banchereau J. Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3. J Exp Med 179 2 (1994) 757-762
3. Groom J.R., Fletcher C.A., Walters S.N., Grey S.T., Watt S.V., Sweet M.J., et al. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med 204 8 (2007) 1959-1971
4. Litinskiy M.B., Nardelli B., Hilbert D.M., He B., Schaffer A., Casali P., et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 3 9 (2002) 822-829
5. Pene J., Gauchat J.F., Lecart S., Drouet E., Guglielmi P., Boulay V., et al. Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol 172 9 (2004) 5154-5157
6. Jacobi A.M., Reiter K., Mackay M., Aranow C., Hiepe F., Radbruch A., et al. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum 58 6 (2008) 1762-1773
7. Wehr C., Eibel H., Masilamani M., Illges H., Schlesier M., Peter H.H., et al. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol 113 2 (2004) 161-171
8. DeGiorgio L.A., Konstantinov K.N., Lee S.C., Hardin J.A., Volpe B.T., and Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 7 11 (2001) 1189-1193
9. Kowal C., Degiorgio L.A., Lee J.Y., Edgar M.A., Huerta P.T., Volpe B.T., et al. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci U S A 103 52 (2006) 19854-19859
10. Zhang J., Jacobi A.M., Mackay M., Aranow C., Wang T., Chinnasamy P., et al. Identification of DNA-reactive B cells in patients with systemic lupus erythematosus. J Immunol Methods 338 1-2 (2008) 79-84
11. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40 9 (1997) 1725
12. Wardemann H., Yurasov S., Schaefer A., Young J.W., Meffre E., and Nussenzweig M.C. Predominant autoantibody production by early human B cell precursors. Science 301 5638 (2003) 1374-1377
13. Zhao Z., Weinstein E., Tuzova M., Davidson A., Mundel P., Marambio P., et al. Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 52 2 (2005) 522-530
14. Zhou Z.H., Tzioufas A.G., and Notkins A.L. Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells. J Autoimmun 29 4 (2007) 219-228
15. Ehrenstein M.R., Cook H.T., and Neuberger M.S. Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J Exp Med 191 7 (2000) 1253-1258
16. Mietzner B., Tsuiji M., Scheid J., Velinzon K., Tiller T., Abraham K., et al. Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci U S A 105 28 (2008) 9727-9732
17. Lee J.Y., Huerta P.T., Zhang J., Kowal C., Bertini E., Volpe B.T., et al. Maternal lupus and congenital cortical impairment. Nat Med 15 (2009) 91-96