Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells

Biochemical and Biophysical Research Communications

Volumn 434, Issue 3, 2013, Pages 634-640

  Seo, Kang Sik ^a   Kim, Hoon ^b   Hong, Tae Hwa ^a   Kim, Jong Seok ^a   Song, Kyoung Sub ^a   Yun, Eun Jin ^a   Park, Ji Hoon ^a   Jung, Young Hoon ^c   Park, Jong Il ^a   Kweon, Gi Ryang ^a   Yoon, Wan Hee ^a   Lim, Kyu ^a   Hwang, Byung Doo ^a  

^a Chungnam National University   (South Korea)

^b Eulji University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Apicularen A acetate; Apoptosis inducing factor; Caspase independent apoptosis; Microtubule disruption

Indexed keywords

ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; APICULAREN A ACETATE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TUBULIN; UNCLASSIFIED DRUG; APICULAREN A; FUSED HETEROCYCLIC RINGS;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DISRUPTION; CELL FRACTIONATION; CELL VIABILITY; COLON CARCINOMA; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MICROTUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; COLON TUMOR; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROTUBULES; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUBULIN;

MLCS; MLOWN;

EID: 84880482712     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.133     Document Type: Article

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