Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH

Toxicology

Volumn 231, Issue 2-3, 2007, Pages 210-214

  Zilz, Thomas R ^a   Griffiths, Helen R ^a   Coleman, Michael D ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Flow cytometry; Hexanediones; Neuroblastoma; SK N SH

Indexed keywords

2,3 HEXANEDIONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3,4 HEXANEDIONE; ACETONYLACETONE; FOOD ADDITIVE; MITOCHONDRIAL ENZYME; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN; CELL STRAIN SK N SH; CHROMOSOME SEGREGATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; ISOMER; METABOLITE; NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; PRIORITY JOURNAL; TOXIN ANALYSIS;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FOOD ADDITIVES; FORMAZANS; HEXANONES; HUMANS; ISOMERISM; NECROSIS; NEUROBLASTOMA; NEURONS; NEUROTOXINS; TETRAZOLIUM SALTS;

EID: 33847155066     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.12.002     Document Type: Article

References (17)

1. Dorado L., Montoya M.R., and Mellado J.M.R. A contribution to the study of the structure mutagenicity relationship for alpha-dicarbonyl compounds using the Ames test. Mutat. Res. 269 (1992) 301-306
2. Heijink E., Scholten S.W., Bolhuis P.A., and de Wolff F.A. Effects of 2,5-hexanedione on calpain-mediated degradation of human neurofilaments in vitro. Chem-Biol. Interact. 129 (2000) 231-247
3. Joint FAO/WHO Expert Committee on Food Additives, 51st Meeting, Geneva, June 9-18, 1998.
4. LoPachin R.M., and DeCaprio A.P. γ-Diketone neuropathy: axon atrophy and role of cytoskeletal protein adduction. Toxicol. Appl. Pharmacol. 199 (2004) 20-34
5. LoPachin R.M., and DeCaprio A.P. Protein adduct formation as a molecular mechanism in neurotoxicity. Toxicol. Sci. 86 (2005) 214-225
6. Nicoletti I., Migliorati G., Pagliaccii M., Grignani F., and Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow-cytometry. J. Immunol. Meth. 139 (1991) 271-279
7. Nishimura Y., Kanada A., Yamaguchi J.Y., Horimoto K., Kobayashi M., Tatsuishi T., Kanemaru K., Ueno S.Y., and Oyama Y. Cytometric analysis of lidocaine-induced cytotoxicity: a model experiment using rat thymocytes. Toxicology 218 (2006) 48-57
8. Perani A., Gerardin C., Stacey G., Infante M.R., Vinardell P., Rodehuser L., Selve C., and Maugras M. Interactions of surfactants with living cells. Induction of apoptosis by detergents containing a beta-lactam moiety. Amino Acids 21 (2001) 185-194
9. Selkoe D.J., Luckenbill-Edds L., and Shalanski M.L. Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives. J. Neuropathol Exp. Neurol 37 (1978) 768-789
10. Stipani I., Mangiullo G., Stipani V., Daddabbo L., Natuzzi D., and Palmieri F. Inhibition of the reconstituted mitochondrial oxoglutarate carrier by arginine-specific reagents. Arch. Biochem. Biophys. 331 (1996) 48-54
11. Stone J.D., Peterson A.P., Eyer J., Oblak T.G., and Sickles D.W. Axonal neurofilaments are nonessential elements of toxicant-induced reductions in fast axonal transport: video-enhanced differential interference microscopy in peripheral nervous system axons. Tox. App. Pharm. 161 (1999) 50-58
12. Stone J.D., Peterson A.P., Eyer J., Oblak T.G., and Sickles D.W. Neurofilaments are non-essential elements of toxicant-induced reductions in fast axonal transport: pulse labeling in CNS neurons. Neurotoxicology 21 (2000) 447-457
13. Tada H., Shiho O., Kuroshima K., Koyama M., and Tsukamoto K. An improved colorimetric assay for interleukin-2. J. Immunol. Meth. 93 (1986) 157-165
14. Woehrling E.K., Zilz T.R., and Coleman M.D. The effects of hexanediones on neural and astrocytic cell lines. Env. Tox. Pharmacol. 22 (2006) 249-254
15. Yuan L., Yu W.M., and Qu C.K. SHP-2 phosphatase regulates DNA-damage-induced apoptosis and G2/M arrest catalytically dependent and independent manners respectively. J. Biol. Chem. 280 (2005) 42701-42706
16. Zhu M., Spink D.C., Yan B., Bank S., and DeCaprio A.P. Formation and structure of cross-linking and monomeric pyrrole autoxidation products in 2,5-hexanedione-treated amino acids, peptides and protein. Chem. Res. Toxicol. 7 (1994) 551-558
17. Zimmermann F.K., and Mohr A. Formaldehyde, glyoxal, urethane, methyl carbamate, 2,3-butanedione, 2,3-hexanedione, ethyl acrylate, dibromoacetonitrile and 2-hydroxypropionitrile induce chromosome loss in saccharomyces-cerevisiae. Mutat. Res. 270 (1992) 151-166