Myomaker is a membrane activator of myoblast fusion and muscle formation

Nature

Volumn 499, Issue 7458, 2013, Pages 301-305

  Millay, Douglas P ^a   O'Rourke, Jason R ^a   Sutherland, Lillian B ^a   Bezprozvannaya, Svetlana ^a   Shelton, John M ^b   Bassel Duby, Rhonda ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CKM PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MYH4 PROTEIN; MYOGENIN; MYOMAKER PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

BIOMARKER; MAMMAL; MEMBRANE; MORTALITY; MUSCLE; PROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUSION; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; GENE DISRUPTION; GENE OVEREXPRESSION; MOUSE; MUSCLE DEVELOPMENT; MUSCLE REGENERATION; MYOBLAST; NONHUMAN; PERINATAL DEATH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ANIMALS; CELL FUSION; CELL LINE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE DEVELOPMENT; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOBLASTS;

EID: 84880397926     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12343     Document Type: Article

References (32)

1. Chen, E. H.&Olson, E. N.Unveiling themechanismsof cell-cell fusion. Science 308, 369-373 (2005).
2. Bentzinger, C. F., Wang, Y. X. & Rudnicki, M. A. Building muscle: molecular regulation of myogenesis. Cold Spring Harb. Perspect. Biol. 4, a008342 (2012).
3. Berkes, C. A. & Tapscott, S. J. MyoD and the transcriptional control of myogenesis. Semin. Cell Dev. Biol. 16, 585-595 (2005).
4. Buckingham, M. Myogenic progenitor cells and skeletal myogenesis in vertebrates. Curr. Opin. Genet. Dev. 16, 525-532 (2006).
5. Kang, J. S. & Krauss, R. S. Muscle stem cells in developmental and regenerative myogenesis. Curr. Opin. Clin. Nutr. Metab. Care 13, 243-248 (2010).
6. Abmayr, S. M. & Pavlath, G. K. Myoblast fusion: lessons from flies and mice. Development 139, 641-656 (2012).
7. Rochlin, K., Yu, S., Roy, S. & Baylies, M. K. Myoblast fusion: when it takes more to make one. Dev. Biol. 341, 66-83 (2010).
8. Charrasse, S. et al. M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion. Mol. Biol. Cell 18, 1734-1743 (2007).
9. Charrasse, S., Meriane, M., Comunale, F., Blangy, A. & Gauthier-Rouviere, C. N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts. J. Cell Biol. 158, 953-965 (2002).
10. Schwander, M. et al. β1 integrins regulate myoblast fusion and sarcomere assembly. Dev. Cell 4, 673-685 (2003).
11. Griffin, C. A., Kafadar, K. A. & Pavlath, G. K. MOR23 promotes muscle regeneration and regulates cell adhesion and migration. Dev. Cell 17, 649-661 (2009).
12. Yagami-Hiromasa, T. et al. Ametalloprotease-disintegrin participating inmyoblast fusion. Nature 377, 652-656 (1995).
13. Davis, R. L., Weintraub, H. & Lassar, A. B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51, 987-1000 (1987).
14. Hasty, P. et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364, 501-506 (1993).
15. Vasyutina, E., Martarelli, B., Brakebusch, C., Wende, H. & Birchmeier, C. The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse. Proc. Natl Acad. Sci. USA 106, 8935-8940 (2009).
16. Gruenbaum-Cohen, Y. et al.The actin regulator N-WASpis required formuscle-cell fusion in mice. Proc. Natl Acad. Sci. USA 109, 11211-11216 (2012).
17. Wright, L. P. & Philips, M. R. Thematic review series: lipid posttranslational modifications. CAAXmodification andmembrane targeting of Ras. J. Lipid Res. 47, 883-891 (2006).
18. Pei, J., Millay, D. P., Olson, E. N. & Grishin, N. V. CREST-a large and diverse superfamily of putative transmembrane hydrolases. Biol. Direct 6, 37 (2011).
19. Corcoran, J. A. & Duncan, R. Reptilian reovirus utilizes a small type III protein with an external myristylated amino terminus to mediate cell-cell fusion. J. Virol. 78, 4342-4351 (2004).
20. Chen, E. H. & Olson, E. N. Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila. Dev. Cell 1, 705-715 (2001).
21. Chen, E. H., Pryce, B. A., Tzeng, J. A., Gonzalez, G. A. & Olson, E. N. Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. Cell 114, 751-762 (2003).
22. Nowak, S. J., Nahirney, P. C., Hadjantonakis, A. K. & Baylies, M. K. Nap1-mediated actin remodeling is essential for mammalian myoblast fusion. J. Cell Sci. 122, 3282-3293 (2009).
23. Laurin, M. et al. The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. Proc. Natl Acad. Sci. USA 105, 15446-15451 (2008).
24. Powell, G. T. & Wright, G. J. Jamb and jamc are essential for vertebrate myocyte fusion. PLoS Biol. 9, e1001216 (2011).
25. Oren-Suissa, M.& Podbilewicz, B. Cell fusion during development. Trends Cell Biol. 17, 537-546 (2007).
26. Wilson, N. F. & Snell, W. J. Microvilli and cell-cell fusion during fertilization. Trends Cell Biol. 8, 93-96 (1998).
27. Shilagardi, K. et al. Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. Science 340, 359-363 (2013).
28. Skarnes, W. C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337-342 (2011).
29. Hargrave, M. & Koopman, P. In situ hybridization of whole-mount embryos. Methods Mol. Biol. 123, 279-289 (2000).
30. Kitamura, T. et al. Efficient screening of retroviral cDNA expression libraries. Proc. Natl Acad. Sci. USA 92, 9146-9150 (1995).
31. Song, K. et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599-604 (2012).
32. Shelton, J. M., Lee, M. H., Richardson, J. A. & Patel, S. B. Microsomal triglyceride transfer protein expression during mouse development. J. Lipid Res. 41, 532-537 (2000). Award Fellowship