Increased thymosin β4 levels in the serum and SF of knee osteoarthritis patients correlate with disease severity

Regulatory Peptides

Volumn 185, Issue , 2013, Pages 34-36

  Wei, Min ^a   Duan, Dongmei ^a   Liu, Yujie ^a   Wang, Zhigang ^a   Li, Zhongli ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Osteoarthritis; Serum; Severity; Synovial fluid; Thymosin 4

Indexed keywords

THYMOSIN BETA4;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; KNEE OSTEOARTHRITIS; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNOVIAL FLUID LEVEL; X RAY;

OSTEOARTHRITIS; SERUM; SEVERITY; SYNOVIAL FLUID; THYMOSIN Β4;

AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; THYMOSIN;

EID: 84880381031     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2013.06.011     Document Type: Article

References (23)

1. Kalai E., Bahlous A., Charni N., Bouzid K., Sahli H., Chelly M., et al. Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis. Clin Lab 2012, 58:209-215.
2. Thompson R.C., Oegema T.R. Metabolic activity of articular cartilage in osteoarthritis. An in vitro study. J Bone Joint Surg Am 1979, 61:407-416.
3. Stannus O., Jones G., Cicuttini F., Parameswaran V., Quinn S., Burgess J., et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 2010, 18:1441-1447.
4. Huff T., Müller C.S., Otto A.M., Netzker R., Hannappel E. beta-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol 2001, 33:205-220.
5. Low T.L., Hu S.K., Goldstein A.L. Complete amino acid sequence of bovine thymosin beta 4: a thymic hormone that induces terminal deoxynucleotidyl transferase activity in thymocyte populations. Proc Natl Acad Sci U S A 1981, 78:1162-1166.
6. Goldstein A.L., Hannappel E., Sosne G., Kleinman H.K. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther 2012, 12:37-51.
7. Blain E.J., Mason D.J., Duance V.C. The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochem Soc Trans 2002, 30:879-882.
8. Nagase H., Woessner J.F. Matrix metalloproteinases. J Biol Chem 1999, 274:21491-21494.
9. Kellgren J.H., Lawrence J.S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957, 16:494-502.
10. Ding C., Cicuttini F., Jones G. How important is MRI for detecting early osteoarthritis?. Nat Clin Pract Rheumatol 2008, 4:4-5.
11. Takahashi M., Naito K., Abe M., Sawada T., Nagano A. Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis. Arthritis Res Ther 2004, 6:R208-R212.
12. Honsawek S., Yuktanandana P., Tanavalee A., Chirathaworn C., Anomasiri W., Udomsinprasert W., et al. Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis. Biomarkers 2012, 17:303-308.
13. Conrozier T., Carlier M.C., Mathieu P., Colson F., Debard A.L., Richard S., et al. Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. Ann Rheum Dis 2000, 59:828-831.
14. Honsawek S., Tanavalee A., Yuktanandana P., Ngarmukos S., Saetan N., Tantavisut S. Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients. BMC Musculoskelet Disord 2010, 11:257.
15. De Santis M., Inzitari R., Bosello S.L., Peluso G., Fanali C., Iavarone F., et al. β-Thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up. Respir Res 2011, 12:22.
16. Han T., Liu Y., Liu H., Zhu Z.Y., Li Y., Xiao S.X., et al. Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure. World J Gastroenterol 2010, 16:625-630.
17. Song R., Choi H.M., Yang H.I., Yoo M.C., Park Y.B., Kim K.S. Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clin Rheumatol 2012, 31:1253-1258.
18. Blain E.J., Mason D.J., Duance V.C. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 2003, 40:111-117.
19. Murphy G., Nagase H. Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?. Nat Clin Pract Rheumatol 2008, 4:128-135.
20. Choi H.M., Lee Y.A., Yang H.I., Yoo M.C., Kim K.S. Increased levels of thymosin β4 in synovial fluid of patients with rheumatoid arthritis: association of thymosin β4 with other factors that are involved in inflammation and bone erosion in joints. Int J Rheum Dis 2011, 14:320-324.
21. Philp D., Scheremeta B., Sibliss K., Zhou M., Fine E.L., Nguyen M., et al. Thymosin beta4 promotes matrix metalloproteinase expression during wound repair. J Cell Physiol 2006, 208:195-200.
22. Grassi F., Cristino S., Toneguzzi S., Piacentini A., Facchini A., Lisignoli G. CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients. J Cell Physiol 2004, 199:244-251.
23. Li N.G., Shi Z.H., Tang Y.P., Wang Z.J., Song S.L., Qian L.H., et al. New hope for the treatment of osteoarthritis through selective inhibition of MMP-13. Curr Med Chem 2011, 18:977-1001.