Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure

World Journal of Gastroenterology

Volumn 16, Issue 5, 2010, Pages 625-630

  Han, Tao ^a   Liu, Ying ^a   Liu, Huan ^a   Zhu, Zheng Yan ^a   Li, Yan ^a   Xiao, Shi Xiang ^a   Guo, Zhen ^a   Zhao, Zhen Gang ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Biochemistry; Hepatitis B virus; Liver failure; Serum; Thymosin 4

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLINESTERASE; THYMOSIN BETA4; THYMOSIN; THYMOSIN BETA(4);

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHRONIC HEPATITIS; CONTROLLED STUDY; CONVALESCENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HORMONE BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER CIRRHOSIS; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; SCORING SYSTEM; THROMBOCYTE; BLOOD; METABOLISM; MIDDLE AGED; PATHOGENICITY; PREDICTION AND FORECASTING; RECEIVER OPERATING CHARACTERISTIC; SURVIVAL RATE; VIROLOGY;

ADULT; FEMALE; HEPATITIS B VIRUS; HUMANS; LIVER FAILURE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; ROC CURVE; SURVIVAL RATE; THYMOSIN;

EID: 76549132349     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i5.625     Document Type: Article

References (22)

1. Sarin SK, Kumar A, Almeida JA, Chawla YK, Fan ST, Garg H, de Silva HJ, Hamid SS, Jalan R, Komolmit P, Lau GK, Liu Q, Madan K, Mohamed R, Ning Q, Rahman S, Rastogi A, Riordan SM, Sakhuja P, Samuel D, Shah S, Sharma BC, Sharma P, Takikawa Y, Thapa BR, Wai CT, Yuen MF. Acuteon-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 2009; 3: 269-282
2. Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 2004; 350: 1118-1129
3. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver 2002; 22 Suppl 2: 5-13
4. Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000; 32: 734-739
5. Jalan R, Williams R. Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif 2002; 20: 252-261
6. Renner EL. How to decide when to list a patient with acute liver failure for liver transplantation? Clichy or King's College criteria, or something else? J Hepatol 2007; 46: 554-557
7. Hannappel E, Xu GJ, Morgan J, Hempstead J, Horecker BL. Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues. Proc Natl Acad Sci USA 1982; 79: 2172-2175
8. Low TL, Goldstein AL. Chemical characterization of thymosin beta 4. J Biol Chem 1982; 257: 1000-1006
9. Marx J. Biomedicine. Thymosins: clinical promise after a decades-long search. Science 2007; 316: 682-683
10. Cha HJ, Jeong MJ, Kleinman HK. Role of thymosin beta4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 2003; 95: 1674-1680
11. Philp D, Huff T, Gho YS, Hannappel E, Kleinman HK. The actin binding site on thymosin beta4 promotes angiogenesis. FASEB J 2003; 17: 2103-2105
12. Li X, Zheng L, Peng F, Qi C, Zhang X, Zhou A, Liu Z, Wu S. Recombinant thymosin beta 4 can promote full-thickness cutaneous wound healing. Protein Expr Purif 2007; 56: 229-236
13. Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 2007; 445: 177-182
14. Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M. Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells. Ann N Y Acad Sci 2007; 1112: 154-160
15. Rutherford A, Chung RT. Acute liver failure: mechanisms of hepatocyte injury and regeneration. Semin Liver Dis 2008; 28: 167-174
16. Tomiya T, Omata M, Imamura H, Fujiwara K. Impaired liver regeneration in acute liver failure: the significance of cross-communication of growth associated factors in liver regeneration. Hepatol Res 2008; 38: S29-S33
17. Nishino M, Iimuro Y, Ueki T, Hirano T, Fujimoto J. Hepatocyte growth factor improves survival after partial hepatectomy in cirrhotic rats suppressing apoptosis of hepatocytes. Surgery 2008; 144: 374-384
18. Ido A, Tsubouchi H. Translational research to identify clinical applications of hepatocyte growth factor. Hepatol Res 2009; 39: 739-747
19. Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, Müller S, Willhauck M, Spitzweg C, Gildehaus FJ, Münzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C. Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation 2008; 117: 2232-2240
20. Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol 2009; 46: 728-738
21. Ho JH, Tseng KC, Ma WH, Chen KH, Lee OK, Su Y. Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Br J Ophthalmol 2008; 92: 992-997
22. Badamchian M, Fagarasan MO, Danner RL, Suffredini AF, Damavandy H, Goldstein AL. Thymosin beta(4) reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock. Int Immunopharmacol 2003; 3: 1225-1233