Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Narayanan, Karthikeyan ^a   Yen, Swee Kuan ^b   Dou, Qingqing ^b   Padmanabhan, Parasuraman ^c   Sudhaharan, Thankiah ^d   Ahmed, Sohail ^a   Ying, Jackie Y ^a   Selvan, Subramanian Tamil ^b,e  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR LOCALIZATION SIGNAL; PEPTIDE; PROTEIN BINDING; QUANTUM DOT;

AMINO ACID SEQUENCE; CELL NUCLEUS; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; ENDOSOME; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; MICROTUBULE; MOLECULAR GENETICS; NUCLEAR LOCALIZATION SIGNAL; SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL; ARTICLE; PROTEIN BINDING;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CELL NUCLEUS; ENDOSOMES; HUMANS; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; MICROTUBULES; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PEPTIDES; PROTEIN BINDING; QUANTUM DOTS; SOLUBILITY;

EID: 84880367796     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02184     Document Type: Article

References (42)

1. Gao, X., Cui, Y., Levenson, R. M., Chung, L.W. & Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004). (Pubitemid 39014473)
2. Medintz, I. L., Uyeda, H. T., Goldman, E. R. & Mattoussi, H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 4, 435-446 (2005). (Pubitemid 40774047)
3. Michalet, X. et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544 (2005). (Pubitemid 40165671)
4. Shen, R. et al. Multifunctional conjugates to prepare nucleolar-targeting CdS quantum dots. J. Am. Chem. Soc. 132, 8627-8634 (2010).
5. Jiang, W., Kim, B. Y., Rutka, J. T. & Chan, W. C. Nanoparticle-mediated cellular response is size-dependent. Nat. Nanotechnol. 3, 145-150 (2008). (Pubitemid 351355131)
6. Kim, B. et al. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat. Nanotechnol. 5, 465-472 (2010).
7. Petros, R. A. & DeSimone, J. M. Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discov. 9, 615-627 (2010).
8. Krpetic, Z. et al.Negotiation of intracellular membrane barriers by TAT-modified gold nanoparticles. ACS Nano 5, 5195-5201 (2011).
9. Wei, Y., Jana, N. R., Tan, S. J., Ying, J. Y. Surface coating directed cellular delivery of TAT-functionalized quantum dots. Bioconjugate Chem. 20, 1752-1758 (2009).
10. Lagerholm, B. C. et al. Multicolor coding of cells with cationic peptide coated quantum dots. Nano Lett. 4, 2019-2022 (2004).
11. Anas, A. et al. Clathrin-mediated endocytosis of quantum dot-peptide conjugates in living cells. ACS Nano 3, 2419-2429 (2009).
12. Smith, B. R. et al. Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature. Nano Lett. 8, 2599-2606 (2008).
13. Ruan,G., Agrawal, A.,Marcus, A. I., S. Imaging and tracking of Tat peptideconjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. J. Am. Chem. Soc. 129, 14759-14766 (2007). (Pubitemid 350207890)
14. Delehanty, J. B. et al. Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery. Bioconjugate Chem. 17, 920-927 (2006). (Pubitemid 44162609)
15. Chen, F. & Gerion, D. Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett. 4, 1827-1832 (2004).
16. Folkman, J. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov. 6, 273-286 (2007). (Pubitemid 46505878)
17. Pooga, M. et al. Cellular translocation of proteins by transportan. The FASEB Journal 15, 1451-1453 (2001).
18. Muratovska, A. & Eccles, M. R. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. 558, 63-68 (2004). (Pubitemid 38167411)
19. Koppelhus, U. & Nielsen, P. E. Cellular delivery of peptide nucleic acid (PNA). Adv. Drug Deliv. Rev. 55, 267-280 (2003). (Pubitemid 36135918)
20. Chan, W. C. & Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016-2018 (1998). (Pubitemid 28475486)
21. Mattoussi, H. et al. Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J. Am. Chem. Soc. 122, 12142-12150 (2000). (Pubitemid 32062250)
22. Pathak, S., Choi, S. K., Arnheim, N. & Thompson, M. E. Hydroxylated quantum dots as luminescent probes for in situ hybridization. J. Am. Chem. Soc. 123, 4103-4104 (2001). (Pubitemid 32899504)
23. Pinaud, F., King, D., Moore, H. P. & Weiss, S. Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides. J. Am. Chem. Soc. 126, 6115-6123 (2004). (Pubitemid 38637980)
24. Yi, D. K. et al. Silica-coated nanocomposites of magnetic nanoparticles and quantum dots. J. Am. Chem. Soc. 127, 4990-4991 (2005). (Pubitemid 40523437)
25. Tan, T. T., Selvan, S. T., Zhao, L., Gao, S., Ying, J. Y. Size control, shape evolution, and silica coating of near-infrared-emitting PbSe quantum dots. Chem.Mater. 19, 3112-3117 (2007). (Pubitemid 47150354)
26. Selvan, S. T., Tan, T. T. & Ying, J. Y. Robust, Non-cytotoxic, silica-coated CdSe quantum dots with efficient photoluminescence. Adv. Mater. 17, 1620-1625 (2005). (Pubitemid 40963859)
27. Selvan, S. T., Patra, P. K., Ang, C. Y. & Ying, J. Y. Synthesis of silica-coated semiconductor and magnetic quantum dots and their use in the imaging of live cells. Angew. Chem. Int. Ed. 46, 2448-2452 (2007). (Pubitemid 46973588)
28. Zhang, F. et al. Polymer-Coated Nanoparticles: A universal tool for biolabelling experiments. Small 7, 3113-3127 (2011).
29. Duan, H. & Nie, S. Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings. J. Am. Chem. Soc. 129, 3333-3338 (2007).
30. Schieber, C. et al. Conjugation of transferrin to azide-modified CdSe/ZnS core-shell quantum dots using cyclooctyne click chemistry. Angew. Chem. Int. Ed. 51, 10523-10527 (2012).
31. Vale, R. D. The molecular motor toolbox for intracellular transport. Cell 112, 467-480 (2003). (Pubitemid 36263080)
32. Arnold, D. B. Actin and microtubule-based cytoskeletal cues direct polarized targeting of proteins in neurons. Sci. Signal 2, pe49 (2009).
33. Roth, D. M., Moseley, G. W., Glover, D., Pouton, C. W. & Jans, D. A. A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic 8, 673-686 (2007). (Pubitemid 46785150)
34. Giannakakou, P. et al. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Nat. Cell Biol. 2, 709-717 (2000).
35. Lam, M. H. et al. Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules. Mol. Endocrinol. 16, 390-401 (2002). (Pubitemid 34131233)
36. Roth, D. M., Moseley, G. W., Pouton, C. W. & Jans, D. A. Mechanism of microtubule-facilitated "fast track" nuclear import. J. Biol. Chem. 286, 14335-14351 (2011).
37. Rajendran, L., Knölker, H.-J., Simons, K. Subcellular targeting strategies for drug design and delivery. Nat. Rev. 9, 29-42 (2010).
38. Liu, X., Yu, M., Kim, H., Mameli, M. & Stellacci, F. Determination of monolayerprotected gold nanoparticle ligand-shell morphology using NMR. Nat. Commun. 3, 1182, doi: 10.1038/ncomms2155 (2012).
39. Verma, A. et al. Surface Structure-Regulated Cell Membrane Penetration by Monolayer Protected Nanoparticles. Nat Mater. 7, 588-595 (2008).
40. Xu, J. et al. Nanoblade delivery and incorporation of quantum dot conjugates into tubulin networks in live cells. Nano Lett. 12, 5669-5672 (2012).
41. Peng, Z. A. & Peng, X. Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. J. Am. Chem. Soc. 123, 183-184 (2001). (Pubitemid 32052980)
42. Peng, Z. A. & Peng, X. Nearly monodisperse and shape-controlled CdSe nanocrystals via alternative routes: nucleation and growth. J. Am. Chem. Soc. 124, 3343-3353 (2002). (Pubitemid 34270375)