Antifibrotic effect of synthetic Smad/Sp1 chimeric decoy oligodeoxynucleotide through the regulation of epithelial mesenchymal transition in unilateral ureteral obstruction model of mice

Experimental and Molecular Pathology

Volumn 95, Issue 2, 2013, Pages 136-143

  Sung, Woo Jung ^a   Kim, Kyung Hyun ^a   Kim, Yong Jin ^b   Chang, Young Chae ^a   Lee, In Hee ^a   Park, Kwan Kyu ^a  

^a Catholic University of Daegu   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

Author keywords

Decoy oligodeoxynucloeotide; EMT; Renal fibrosis; Smad; Sp1; TGF 1

Indexed keywords

ANTIFIBROTIC AGENT; OLIGODEOXYNUCLEOTIDE DERIVATIVE; SMAD PROTEIN; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; EPITHELIAL MESENCHYMAL TRANSITION; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REGULATORY MECHANISM; URETER OBSTRUCTION;

DECOY OLIGODEOXYNUCLOEOTIDE; EMT; RENAL FIBROSIS; SMAD; SP1; TGF-Β1;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; MALE; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; SMAD PROTEINS; SP1 TRANSCRIPTION FACTOR; URETERAL OBSTRUCTION;

EID: 84880360293     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2013.06.008     Document Type: Article

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