Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 29, 2013, Pages 11893-11898

  Sacilotto, Natalia ^a   Monteiro, Rui ^b   Fritzsche, Martin ^a   Becker, Philipp W ^a   Sanchez del Campo, Luis ^a   Liu, Ke ^c   Pinheiro, Philip ^b   Ratnayaka, Indrika ^a   Davies, Benjamin ^d   Goding, Colin R ^a   Patient, Roger ^b   Bou Gharios, George ^c   De Val, Sarah ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Arterial Specific Enhancer; Csl

Indexed keywords

DELTA LIKE LIGAND 4; NOTCH RECEPTOR; TRANSCRIPTION FACTOR SOX; TRANSCRIPTION FACTOR SOX18; TRANSCRIPTION FACTOR SOX7; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENHANCER REGION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ZEBRA FISH;

ARTERIAL-SPECIFIC ENHANCER; CSL;

ANIMALS; ARTERIES; CHROMATIN IMMUNOPRECIPITATION; CLONING, MOLECULAR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; RECEPTORS, NOTCH; SOXF TRANSCRIPTION FACTORS; ZEBRAFISH;

EID: 84880356030     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300805110     Document Type: Article

References (36)

1. Potente M, Gerhardt H, Carmeliet P (2011) Basic and therapeutic aspects of angiogenesis. Cell 146(6):873-887.
2. Schepers GE, Teasdale RD, Koopman P (2002) Twenty pairs of sox: Extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 3(2):167-170.
3. Mertin S, McDowall SG, Harley VR (1999) The DNA-binding specificity of SOX9 and other SOX proteins. Nucleic Acids Res 27(5):1359-1364.
4. Cermenati S, et al. (2008) Sox18 and Sox7 play redundant roles in vascular development. Blood 111(5):2657-2666.
5. Herpers R, van de Kamp E, Duckers HJ, Schulte-Merker S (2008) Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish. Circ Res 102(1):12-15.
6. Pendeville H, et al. (2008) Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Dev Biol 317(2):405-416.
7. Sakamoto Y, et al. (2007) Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun 360(3): 539-544.
8. Francois M, Koopman P, Beltrame M (2010) SoxF genes: Key players in the development of the cardio-vascular system. Int J Biochem Cell Biol 42(3):445-448.
9. Engert S, Liao WP, Burtscher I, Lickert H (2009) Sox17-2A-iCre: A knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells. Genesis 47(9): 603-610.
10. Lawson ND, et al. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development 128(19):3675-3683.
11. Gridley T (2007) Notch signaling in vascular development and physiology. Development 134(15):2709-2718.
12. Krebs LT, et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 18(20):2469-2473.
13. Duarte A, et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev 18(20):2474-2478.
14. Gale NW, et al. (2004) Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 101(45):15949-15954.
15. Lawson ND, Vogel AM, Weinstein BM (2002) Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3(1):127-136.
16. Maston GA, Evans SK, Green MR (2006) Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet 7:29-59.
17. Lee D, et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2(5):497-507.
18. De Val S, Black BL (2009) Transcriptional control of endothelial cell development. Dev Cell 16(2):180-195.
19. Heintzman ND, et al. (2009) Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459(7243):108-112.
20. Benedito R, Duarte A (2005) Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns 5(6):750-755.
21. Birnbaum RY, et al. (2012) Functional characterization of tissue-specific enhancers in the DLX5/6 locus. Hum Mol Genet 21(22):4930-4938.
22. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positionspecific gap penalties and weight matrix choice. Nucleic Acids Res 22(22):4673-4680.
23. Seo S, et al. (2006) The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol 294(2):458-470.
24. Frankel N (2012) Multiple layers of complexity in cis-regulatory regions of developmental genes. Dev Dyn 241(12):1857-1866.
25. Siekmann AF, Lawson ND (2007) Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 445(7129):781-784.
26. Lawson ND, Weinstein BM (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol 248(2):307-318.
27. Herbert SP, et al. (2009) Arterial-venous segregation by selective cell sprouting: An alternative mode of blood vessel formation. Science 326(5950):294-298.
28. Corada M, et al. (2010) The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 18(6): 938-949.
29. Yamamizu K, et al. (2010) Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol 189(2):325-338.
30. Sinner D, Rankin S, Lee M, Zorn AM (2004) Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 131(13):3069-3080.
31. De Val S, et al. (2004) Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol 275(2): 424-434.
32. Kawakami K (2005) Transposon tools and methods in zebrafish. Dev Dyn 234(2): 244-254.
33. Jin SW, Beis D, Mitchell T, Chen JN, Stainier DY (2005) Cellular and molecular analyses of vascular tube and lumen formation in zebrafish. Development 132(23): 5199-5209.
34. Traver D, et al. (2003) Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol 4(12):1238-1246.
35. Gering M, Patient R (2005) Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 8(3):389-400.
36. Sacilotto N, Espert A, Castillo J, Franco L, López-Rodas G (2011) Epigenetic transcriptional regulation of the growth arrest-specific gene 1 (Gas1) in hepatic cell proliferation at mononucleosomal resolution. PLoS ONE 6(8):e23318.