Ethanol inhibits retinal and CNS differentiation due to failure of cell cycle exit via an apoptosis-independent pathway

Neurotoxicology and Teratology

Volumn 38, Issue , 2013, Pages 92-103

  Chung, Hsin Yu ^a   Chang, Chin Teng ^a   Young, Huay Win ^a   Hu, Shing P ^b   Tzou, Wen Shyong ^a   Hu, Chin Hwa ^a  

^a NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Ethanol; Neural differentiation; ROS; Zebrafish

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASCL1B GENE; BIOACCUMULATION; CCND1 GENE; CCNE GENE; CDKN1B GENE; CDKN1C GENE; CELL CYCLE ARREST; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CRX GENE; ELAVL3 GENE; EMBRYO; EMBRYO DEVELOPMENT; EYE TOXICITY; GENE; INTRACELLULAR SIGNALING; LONG TERM EXPOSURE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; PAX6B GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEVELOPMENT; RETINA DISEASE; RHO GENE; ZEBRA FISH;

APOPTOSIS; ETHANOL; NEURAL DIFFERENTIATION; ROS; ZEBRAFISH;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; ETHANOL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; NEURAL STEM CELLS; NEUROGENESIS; REACTIVE OXYGEN SPECIES; RETINA; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53; ZEBRAFISH;

EID: 84880345912     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2013.05.006     Document Type: Article

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