Early molecular effects of ethanol during vertebrate embryogenesis

Differentiation

Volumn 75, Issue 5, 2007, Pages 393-403

  Yelin, Ronit ^a   Kot, Hadas ^a   Yelin, Dvir ^b   Fainsod, Abraham ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Craniofacial malformations; Eye formation; Fetal alcohol syndrome; Head development; Microcephaly; Microphthalmia; Neural tube; Notochord; Prechordal plate; Spemann's organizer; Teratogen; XCG1

Indexed keywords

ALCOHOL; CHORDIN; GENE PRODUCT; PROTEIN EN2; PROTEIN FOXA4B; PROTEIN GSC; PROTEIN TBX3; PROTEIN XBRA; PROTEIN XNOT2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ARTICLE; BRAIN MALFORMATION; BRAIN REGION; BRAIN VENTRICLE; CEPHALOMETRY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO DEVELOPMENT; FETAL ALCOHOL SYNDROME; FOREBRAIN; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; HISTOPATHOLOGY; INVAGINATION; MOLECULAR DYNAMICS; NEURULATION; NONHUMAN; NOTOCHORD; OPTOMETRY; PRIORITY JOURNAL; SPINAL CORD; TERATOGENICITY; XENOPUS;

VERTEBRATA;

EID: 34249033937     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2006.00147.x     Document Type: Article

References (61)

1. Becker, H.C., Diaz-Granados, J.L. Randall, C.L. (1996) Teratogenic actions of ethanol in the mouse: a mini review. Pharmacol Biochem Behav 55 : 501 513.
2. Blader, P. Strahle, U. (1998) Ethanol impairs migration of the prechordal plate in the zebrafish embryo. Dev Biol 201 : 185 201.
3. Blitz, I.L. Cho, K.W.Y. (1995) Anterior neuroectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development 121 : 993 1004.
4. Boehm, S.L., Lundahl, K.R., Caldwell, J. Gilliam, D.M. (1997) Ethanol teratogenesis in the C57BL/6J, DBA/2J and A/J inbred mouse strains. Alcohol 14 : 389 395.
5. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. De Robertis, E.M. (1996) Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382 : 595 601.
6. Bradley, L.C., Alison, S., Bhatt, S. Wilkinson, D.G. (1992) The structure and expression of the Xenopus Krox-20 gene: conserved and divergent patterns of expression in rhombomeres and neural crest. Mech Dev 40 : 73 84.
7. Chaudhuri, J.D. (2000) Alcohol and the developing fetus - a review. Med Sci Monit 6 : 1031 1041.
8. Cho, K.W.Y., Blumberg, B., Steinbeisser, H. De Robertis, E.M. (1991) Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67 : 1111 1120.
9. Clagett-Dame, M. DeLuca, H.F. (2002) The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22 : 347 381.
10. Cook, C.S. Sulik, K.K. (1988) Keratolenticular dysgenesis (Peter's anomaly) as a result of acute insult during gastrulation. J Pediatr Ophtalmol Strabismus 25 : 60 66.
11. de Souza, F.S., Gawantka, V., Gomez, A.P., Delius, H., Ang, S.L. Niehrs, C. (1999) The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer. EMBO J 18 : 6062 6072.
12. Deltour, L., Ang, H.L. Duester, G. (1996) Ethanol inhibiton of retinoic acid synthesis as a potential mechanism for fetal alcohol syndrome. FASEB J 10 : 1050 1057.
13. Dirksen, M.L. Jamrich, M. (1992) A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. Genes Dev 6 : 599 608.
14. Dresser, T.H., Rivera, E.R., Hoffmann, F.J. Finch, R.A. (1992) Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX). J Appl Toxicol 12 : 49 56.
15. Duester, G. (1991) A hypothetical mechanism for fetal alcohol syndrome involving ethanol inhibition of retinoic acid synthesis at the alcohol dehydrogenase step. Alcohol Clin Exp Res 15 : 568 572.
16. Ekker, S.C., McGrew, L.L., Lai, C.J., Lee, J.J., von Kessler, D.P., Moon, R.T. Beachy, P.A. (1995a) Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. Development 121 : 2337 2347.
17. Ekker, S.C., Ungar, A.R., Greenstein, P., von Kessler, D.P., Porter, J.A., Moon, R.T. Beachy, P.A. (1995b) Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol 5 : 944 955.
18. Epstein, M., Pillemer, G., Yelin, R., Yisraeli, J.K. Fainsod, A. (1997) Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes. Development 124 : 3805 3814.
19. Gilliam, D.M., Mantle, M.A., Barkhausen, D.A. Tweden, D.R. (1997) Effects of acute prenatal ehtanol administration in a reciprocal cross of C57BL/6J and short-sleep mice: maternal effects and nonmaternal factors. Alcohol Clin Exp Res 21 : 28 34.
20. Gont, L.K., Steinbeisser, H., Blumberg, B. De Robertis, E.M. (1993) Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development 119 : 991 1004.
21. Grummer, M.A. Zachman, R.D. (1995) Prenatal ethanol consumption alters the expression of cellular retinol binding protein and retinoic acid receptor mRNA in fetal rat embryo and brain. Alcohol Clin Exp Res 19 : 1376 1381.
22. Hemmati-Brivanlou, A., de la Torre, J.R., Holt, C. Harland, R. (1991) Cephalic expression and molecular characterization of Xenopus En-2. Development 111 : 715 724.
23. Hemmati-Brivanlou, A., Frank, D., Bolce, M.E., Brown, B.D., Sive, H.L. Harland, R.M. (1990a) Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization. Development 110 : 325 330.
24. Hemmati-Brivanlou, A., Stewart, R.M. Harland, R.M. (1990b) Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus. Science 250 : 800 802.
25. Henderson, G.I., Baskin, G.S., Horbach, J., Porter, P. Schenker, S. (1989) Arrest of epidermal growth factor-dependent growth in fetal hepatocytes after ethanol exposure. J Clin Invest 84 : 1287 1294.
26. Johnson, V.P., Swayze, V.W. II., Sato, Y. Andreasen, N.C. (1996) Fetal alcohol syndrome: craniofacial and central nervous system manifestations. Am J Med Genet 61 : 329 339.
27. Jones, K.L. Smith, D.W. (1973) Recognition of the fetal alcohol syndrome in early infancy. Lancet 2 : 999 1001.
28. Kazanskaya, O., Glinka, A. Niehrs, C. (2000) The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. Development 127 : 4981 4992.
29. Kesmodel, U., Wisborg, K., Olsen, S.F., Henriksen, T.B. Secher, N.J. (2002a) Moderate alcohol intake during pregnancy and the risk of stillbirth and death in the first year of life. Am J Epidemiol 155 : 305 312.
30. Kesmodel, U., Wisborg, K., Olsen, S.F., Henriksen, T.B. Secher, N.J. (2002b) Moderate alcohol intake in pregnancy and the risk of spontaneous abortion. Alcohol Alcohol 37 : 87 92.
31. Koren, G., Nulman, I., Chudley, A.E. Loocke, C. (2003) Fetal alcohol spectrum disorder. Can Med Assoc J 169 : 1181 1185.
32. Kotch, L.E., Chen, S.Y. Sulik, K.K. (1995) Ethanol-induced teratogenesis: free radical damage as a possible mechanism. Teratology 52 : 128 136.
33. Kozmik, Z. (2005) Pax genes in eye development and evolution. Curr Opin Genet Dev 15 : 430 438.
34. Li, H., Tierney, C., Wen, L., Wu, J.Y. Rao, Y. (1997) A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development 124 : 603 615.
35. Macdonald, R., Barth, K.A., Xu, Q., Holder, N., Mikkola, I. Wilson, S.W. (1995) Midline signalling is required for Pax gene regulation and patterning of the eyes. Development 121 : 3267 3278.
36. Marill, J., Idres, N., Capron, C.C., Nguyen, E. Chabot, G.G. (2003) Retinoic acid metabolism and mechanism of action: a review. Curr Drug Metab 4 : 1 10.
37. Nakatsuji, N. (1983) Craniofacial malformation in Xenopus laevis tadpoles caused by the exposure of early embryos to ethanol. Teratology 28 : 299 305.
38. Nakatsuji, N. Johnson, K.E. (1984) Effects of ethanol on the primitive streak stage mouse embryo. Teratology 29 : 369 375.
39. Niehrs, C., Keller, R., Cho, K.W.Y. De Robertis, E.M. (1993) The homeobox gene goosecoid controls cell migration in Xenopus embryos. Cell 72 : 491 503.
40. Nieuwkoop, P.D. Faber, J. (1967) Normal table of Xenopus laevis (Daudin). North-Holland Publishing Company, Amsterdam.
41. Olney, J.W., Wozniak, D.F., Farber, N.B., Jevtovic-Todorovic, V., Bittigau, P. Lkonomidou, C. (2002) The enigma of fetal alcohol neurotoxicity. Ann Med 34 : 109 119.
42. Oron, D., Yelin, D., Tal, E., Raz, S., Fachima, R. Silberberg, Y. (2004) Depth-resolved structural imaging by third-harmonic generation microscopy. J Struct Biol 147 : 3 11.
43. Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G. Boncinelli, E. (1995) The Xenopus homolog of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development 121 : 707 720.
44. Peng, Y., Yang, P.H., Guo, Y., Ng, S.S., Liu, J., Fung, P.C., Tay, D., Ge, J., He, M.L., Kung, H.F. Lin, M.C. (2004a) Catalase and peroxiredoxin 5 protect Xenopus embryos against alcohol-induced ocular anomalies. Invest Ophthalmol Vis Sci 45 : 23 29.
45. Peng, Y., Yang, P.H., Ng, S.S., Wong, O.G., Liu, J., He, M.L., Kung, H.F. Lin, M.C. (2004b) A critical role of Pax6 in alcohol-induced fetal microcephaly. Neurobiol Dis 16 : 370 376.
46. Pullarkat, R.K. (1991) Hypothesis: prenatal ethanol-induced birth defects and retinoic acid. Alcohol Clin Exp Res 15 : 565 567.
47. Runner, M.N. (1986) Epigenetically regulated genomic expression for shortened stature and cleft palate are regionally specific in the 11-day mouse embryo. J Craniofac Genet Dev Biol Suppl 2 : 137 168.
48. Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L.K. De Robertis, E.M. (1994) Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79 : 779 790.
49. Singh, S.P., Ehmann, S. Snyder, A.K. (1996) Ethanol-induced changes in insulin-like growth factors and IGF gene expression in the fetal brain. Proc Soc Exp Biol Med 212 : 349 354.
50. Smith, J.C., Price, B.M.J., Green, J.B.A., Weigel, D. Herrmann, B.G. (1991) Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67 : 79 87.
51. Smith, W.C., Knecht, A.K., Wu, M. Harland, R.M. (1993) Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm. Nature 361 : 547 549.
52. Sokol, R.J., Delaney-Black, V. Nordstrom, B. (2003) Fetal alcohol spectrum disorder. JAMA 290 : 2996 2999.
53. Sulik, K.K., Johnston, M.C. Webb, M.A. (1981) Fetal alcohol syndrome: embryogenesis in a mouse model. Science 214 : 936 938.
54. Takabatake, Y., Takabatake, T., Sasagawa, S. Takeshima, K. (2002) Conserved expression control and shared activity between cognate T-box genes Tbx2 and Tbx3 in connection with Sonic hedgehog signaling during Xenopus eye development. Dev Growth Differ 44 : 257 271.
55. Tour, E., Pillemer, G., Gruenbaum, Y. Fainsod, A. (2002) Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation. Mech Dev 112 : 141 151.
56. Twal, W.O. Zile, M.H. (1997) Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos. Acohol Clin Exp Res 21 : 1137 1143.
57. von Dassow, G., Schmidt, J.E. Kimelman, D. (1993) Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeobox gene. Genes Dev 7 : 355 366.
58. Weston, W.M., Greene, R.M., Uberti, M. Pisano, M.M. (1994) Ethanol effects on embryonic craniofacial growth and development: implications for study of the fetal alcohol syndrome. Alcohol Clin Exp Res 18 : 177 182.
59. Yelin, D. Silberberg, Y. (1999) Laser scanning third-harmonic generation microscopy in biology. Opt Express 5 : 169 175.
60. Yelin, R., Ben-Haroush Schyr, R., Kot, H., Zins, S., Frumkin, A., Pillemer, G. Fainsod, A. (2005) Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels. Dev Biol 279 : 193 204.
61. Zhang, X.M. Yang, X.J. (2001) Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol 233 : 271 290.