메뉴 건너뛰기




Volumn 1290, Issue 1, 2013, Pages 12-20

Resveratrol in the management of human cancer: How strong is the clinical evidence?

Author keywords

Biomarkers; Cancer; Clinical trial; Colon; Pharmacokinetics; Resveratrol

Indexed keywords

BORTEZOMIB; MIDAZOLAM; PLACEBO; RESVERATROL;

EID: 84880344982     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12205     Document Type: Article
Times cited : (58)

References (39)
  • 1
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur, J.A. & D.A. Sinclair. 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discover. 5: 493-506.
    • (2006) Nat. Rev. Drug Discover. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 2
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health-a comprehensive review of clinical trials
    • Smoliga, J.M., J.A. Baur & H.A. Hausenblas. 2011. Resveratrol and health-a comprehensive review of clinical trials. Mol. Nutr. Food Res. 55: 1129-1141.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 5
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang, M., L. Cai, G.O. Udeani, et al. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218-220.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3
  • 6
    • 67650297506 scopus 로고    scopus 로고
    • Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials
    • Bishayee, A. 2009. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev. Res. 2: 409-418.
    • (2009) Cancer Prev. Res , vol.2 , pp. 409-418
    • Bishayee, A.1
  • 7
    • 45849124668 scopus 로고    scopus 로고
    • Resveratrol as an inhibitor of carcinogenesis
    • Pezzuto, J.M. 2008. Resveratrol as an inhibitor of carcinogenesis. Pharmaceutical Biol. 46, 443-457.
    • (2008) Pharmaceutical Biol. , vol.46 , pp. 443-457
    • Pezzuto, J.M.1
  • 8
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur, J.A., K.J. Pearson, N.L. Price, et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 9
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price, N.L., A.P. Gomes, A.J.Y. Ling, et al. 2012. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15: 675-690.
    • (2012) Cell Metab. , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.Y.3
  • 10
    • 79959261445 scopus 로고    scopus 로고
    • What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    • Vang, O., N. Ahmad, C.A. Baile, et al. 2011. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One 6, e19881.
    • (2011) PLoS One , vol.6
    • Vang, O.1    Ahmad, N.2    Baile, C.A.3
  • 11
    • 68949192688 scopus 로고    scopus 로고
    • Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials
    • Scott, E.N., A.J. Gescher, W.P. Steward & K. Brown. 2009. Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials. Cancer Prev. Res. 2: 525-530.
    • (2009) Cancer Prev. Res. , vol.2 , pp. 525-530
    • Scott, E.N.1    Gescher, A.J.2    Steward, W.P.3    Brown, K.4
  • 12
    • 33745683516 scopus 로고    scopus 로고
    • Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer-a plan to move forward
    • Kelloff, G.J., S.M. Lippman, A.J. Dannenberg, et al. 2006. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer-a plan to move forward. Clin. Cancer Res. 12: 3661-3697.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3661-3697
    • Kelloff, G.J.1    Lippman, S.M.2    Dannenberg, A.J.3
  • 13
    • 84855334376 scopus 로고    scopus 로고
    • Resveratrol in human cancer chemoprevention - choosing the "right" dose
    • Scott, E., W.P. Steward, A.J. Gescher & K. Brown. 2011. Resveratrol in human cancer chemoprevention - choosing the "right" dose. Mol. Nutr. Food Res. 56: 7-13.
    • (2011) Mol. Nutr. Food Res. , vol.56 , pp. 7-13
    • Scott, E.1    Steward, W.P.2    Gescher, A.J.3    Brown, K.4
  • 14
    • 34250901592 scopus 로고    scopus 로고
    • Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    • Boocock, D.J., G.E. Faust, K.R. Patel, et al. 2007. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol. Biomarkers Prev. 16: 1246-1252.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 1246-1252
    • Boocock, D.J.1    Faust, G.E.2    Patel, K.R.3
  • 15
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics and effect on the insulin-like growth factor axis
    • Brown, V., K. Patel, M. Viskaduraki, et al. 2010. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics and effect on the insulin-like growth factor axis. Cancer Res. 70: 9003-9011.
    • (2010) Cancer Res , vol.70 , pp. 9003-9011
    • Brown, V.1    Patel, K.2    Viskaduraki, M.3
  • 16
    • 84866740513 scopus 로고    scopus 로고
    • Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
    • Rotches Ribalta, M., C. Andres-Lacueva, R. Estruch, et al. 2012. Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets. Pharmacol. Res. 66: 375-382.
    • (2012) Pharmacol. Res , vol.66 , pp. 375-382
    • Rotches Ribalta, M.1    Andres-Lacueva, C.2    Estruch, R.3
  • 17
    • 84873368632 scopus 로고    scopus 로고
    • In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota
    • Bode, L.M., D. Bunzel, M. Huch, et al. 2013. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. Am. J. Clin. Nutr. 97: 295-309.
    • (2013) Am. J. Clin. Nutr. , vol.97 , pp. 295-309
    • Bode, L.M.1    Bunzel, D.2    Huch, M.3
  • 18
    • 77957355158 scopus 로고    scopus 로고
    • Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
    • Patel, K.R., V.A. Brown, D.J.L. Jones, et al. 2010. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 70: 7392-7399.
    • (2010) Cancer Res , vol.70 , pp. 7392-7399
    • Patel, K.R.1    Brown, V.A.2    Jones, D.J.L.3
  • 19
    • 80052572943 scopus 로고    scopus 로고
    • Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics
    • Howells, L.M., D.P. Berry, P.J, Elliott, et al. 2011. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res. 4: 1419-1425.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 1419-1425
    • Howells, L.M.1    Berry, D.P.2    Elliott, P.J.3
  • 20
    • 68049147267 scopus 로고    scopus 로고
    • Safety studies conducted on high-purity trans-resveratrol in experimental animals
    • Williams, L.D., G.A. Burdock, J.A. Edwards, et al. 2009. Safety studies conducted on high-purity trans-resveratrol in experimental animals. Food Chem. Toxicol. 47: 2170-2182.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2170-2182
    • Williams, L.D.1    Burdock, G.A.2    Edwards, J.A.3
  • 21
    • 80054853722 scopus 로고    scopus 로고
    • Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity
    • Johnson, W.D., R.L. Morrissey, A.L. Usborne, et al. 2011. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem. Tox. 49: 3319-3327.
    • (2011) Food Chem. Tox. , vol.49 , pp. 3319-3327
    • Johnson, W.D.1    Morrissey, R.L.2    Usborne, A.L.3
  • 22
    • 67649999248 scopus 로고    scopus 로고
    • Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
    • Almeida, L., M. Vaz-da-Silva, A. Falcao, et al. 2009. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res. 53(Suppl 1): S7-S15.
    • (2009) Mol. Nutr. Food Res. , vol.53 , Issue.SUPPL 1
    • Almeida, L.1    Vaz-da-Silva, M.2    Falcao, A.3
  • 23
    • 77953353711 scopus 로고    scopus 로고
    • Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects
    • la Porte, C., N. Voduc, G. Zhang, et al. 2010. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Clin. Pharmacokinet. 49: 449-454.
    • (2010) Clin. Pharmacokinet. , vol.49 , pp. 449-454
    • la Porte, C.1    Voduc, N.2    Zhang, G.3
  • 24
    • 77956412951 scopus 로고    scopus 로고
    • Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study
    • Chow, H.H., L.L. Garland, C.H. Hsu, et al. 2010. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev. Res. 3: 1168-1175.
    • (2010) Cancer Prev. Res. , vol.3 , pp. 1168-1175
    • Chow, H.H.1    Garland, L.L.2    Hsu, C.H.3
  • 25
    • 84873996774 scopus 로고    scopus 로고
    • A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma
    • Popat, R., T. Plesner, F. Davies, et al. 2013. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br. J. Haematol. 160: 714-717.
    • (2013) Br. J. Haematol. , vol.160 , pp. 714-717
    • Popat, R.1    Plesner, T.2    Davies, F.3
  • 27
    • 3042853940 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and cancer risk
    • Ibrahim, Y.H. & D. Yee. 2004. Insulin-like growth factor-1 and cancer risk. Growth Horm. IGF Res. 14: 261-269.
    • (2004) Growth Horm. IGF Res. , vol.14 , pp. 261-269
    • Ibrahim, Y.H.1    Yee, D.2
  • 28
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic isle tumorigenesis
    • Lopez, T. & D. Hanahan. 2002. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic isle tumorigenesis. Cancer Cell 1: 339-353.
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 29
    • 2442673123 scopus 로고    scopus 로고
    • Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor
    • Samani, A.A., E. Chevet, L. Fallavollita, et al. 2004. Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor. Cancer Res. 64: 3380-3385.
    • (2004) Cancer Res , vol.64 , pp. 3380-3385
    • Samani, A.A.1    Chevet, E.2    Fallavollita, L.3
  • 30
    • 0037014743 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    • Sandhu, M.S., D.B. Dunger & E.L. Giovannucci. 2002. Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J. Natl. Cancer Inst. 94: 972-980.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 972-980
    • Sandhu, M.S.1    Dunger, D.B.2    Giovannucci, E.L.3
  • 31
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-1, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    • Renehan, A.G., M. Zwahlen, C. Minder, et al. 2004. Insulin-like growth factor (IGF)-1, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet 363: 1346-1353.
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3
  • 32
    • 79958099432 scopus 로고    scopus 로고
    • Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer
    • Nguyen, A.V., M. Martinez, M.J. Stamos, et al. 2009. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag. Res. 1: 25-37.
    • (2009) Cancer Manag. Res. , vol.1 , pp. 25-37
    • Nguyen, A.V.1    Martinez, M.2    Stamos, M.J.3
  • 33
  • 34
    • 44049086893 scopus 로고    scopus 로고
    • Understanding pathways of calorie restriction: a way to prevent cancer
    • Grifantini, K. 2008. Understanding pathways of calorie restriction: a way to prevent cancer? J. Natl. Cancer Inst. 100: 619-621.
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 619-621
    • Grifantini, K.1
  • 35
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers, S., E. Konings, L. Bilet, et al. 2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14: 612-622.
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 36
    • 84871445402 scopus 로고    scopus 로고
    • Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance
    • Yoshino, J., C. Conte, L. Fontana, et al. 2012. Resveratrol supplementation does not improve metabolic function in non-obese women with normal glucose tolerance. Cell Metab. 16: 658-664.
    • (2012) Cell Metab. , vol.16 , pp. 658-664
    • Yoshino, J.1    Conte, C.2    Fontana, L.3
  • 37
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyo, P., G.A. Molnar, M. Mohas, et al. 2011. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br. J. Nutr. 106: 383-389.
    • (2011) Br. J. Nutr. , vol.106 , pp. 383-389
    • Brasnyo, P.1    Molnar, G.A.2    Mohas, M.3
  • 38
    • 79955675928 scopus 로고    scopus 로고
    • A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal
    • Ghanim, H., C.L. Sia, K. Korzeniewski, et al. 2011. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J. Clin. Endocrinol. Metab. 96: 1409-1414.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1409-1414
    • Ghanim, H.1    Sia, C.L.2    Korzeniewski, K.3
  • 39
    • 78649979775 scopus 로고    scopus 로고
    • Resveratrol commonly displays hormesis: occurrence and biomedical significance
    • Calabrese, E.J., M.P. Mattson & V. Calabrese. 2010. Resveratrol commonly displays hormesis: occurrence and biomedical significance. Hum. Exp. Toxicol. 29: 980-1015.
    • (2010) Hum. Exp. Toxicol , vol.29 , pp. 980-1015
    • Calabrese, E.J.1    Mattson, M.P.2    Calabrese, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.