Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways

Virology Journal

Volumn 10, Issue , 2013, Pages

  Wang, James Cm ^a,b   Felizardo, Tânia C ^c   Au, Bryan Cy ^a   Fowler, Daniel H ^c   Dekaban, Gregory A ^d,e   Medin, Jeffrey A ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF WESTERN ONTARIO   (Canada)

^e ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Dendritic cell longevity lifespan; Dendritic cell vaccine; HER 2 neu; Lentivirus

Indexed keywords

COMPLEMENTARY DNA; DENDRITIC CELL VACCINE; LENTIVIRUS VECTOR; LIPOCORTIN 5;

ANIMAL CELL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BONE MARROW; CELL DEATH; CELL LINE; CONTROLLED STUDY; DENDRITIC CELL; FETAL CALF SERUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOTHERAPY; MOUSE; NONHUMAN; PHENOTYPE; SIGNAL TRANSDUCTION; SURVIVAL FACTOR;

ANIMALS; ANTIGENS, NEOPLASM; APOPTOSIS; CELL SURVIVAL; DENDRITIC CELLS; FLOW CYTOMETRY; GENETIC ENGINEERING; GENETIC VECTORS; LENTIVIRUS; MICE; MICE, INBRED C57BL; TRANSDUCTION, GENETIC;

LENTIVIRUS; MURINAE; RATTUS;

EID: 84880334859     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-10-240     Document Type: Article

References (34)

1. Exposure of myeloid dendritic cells to exogenous or endogenous IL-10 during maturation determines their longevity. Chang WL, Baumgarth N, Eberhardt MK, Lee CY, Baron CA, Gregg JP, Barry PA, J Immunol 2007 178 12 7794 7804 17548617
2. A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Hou WS, Van Parijs L, Nat Immunol 2004 5 6 583 589 10.1038/ni1071 15133508
3. Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. Kamath AT, Henri S, Battye F, Tough DF, Shortman K, Blood 2002 100 5 1734 1741 12176895
4. Tracking dendritic cells in vivo: insights into DC biology and function. Hon H, Jacob J, Immunol Res 2004 29 1-3 69 80 15181271
5. The first 1000 dendritic cell vaccinees. Ridgway D, Canc Invest 2003 21 6 873 886 10.1081/CNV-120025091
6. CD95, BIM and T cell homeostasis. Bouillet P, O'Reilly LA, Nat Rev Immunol 2009 9 7 514 519 10.1038/nri2570 19543226
7. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M, Biochem Pharmacol 2008 76 11 1340 1351 10.1016/j.bcp.2008.07.031 18755156
8. Apoptosis: a review of programmed cell death. Elmore S, Toxicol Pathol 2007 35 4 495 516 10.1080/01926230701320337 17562483
9. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S, J Biol Chem 2001 276 23 20633 20640 10.1074/jbc.M101780200 11279218
10. Inhibition of death receptor signals by cellular FLIP. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J, Nature 1997 388 6638 190 195 10.1038/40657 9217161
11. Bcl-2, Bcl-xL and c-FLIP(L) potentially regulate the susceptibility of human peripheral blood monocyte-derived dendritic cells to cell death at different developmental stages. Hasebe H, Sato K, Yanagie H, Takeda Y, Nonaka Y, Takahashi TA, Eriguchi M, Nagawa H, Biomed Pharmacother 2002 56 3 144 151 10.1016/S0753-3322(02)00164-6 12046686
12. Regulation of the lifespan in dendritic cell subsets. Chen M, Huang L, Shabier Z, Wang J, Mol Immunol 2007 44 10 2558 2565 10.1016/j.molimm.2006.12.020 17267035
13. bcl-xL is critical for dendritic cell survival in vivo. Hon H, Rucker EB 3rd, Hennighausen L, Jacob J, J Immunol 2004 173 7 4425 4432 15383573
14. Inclusion of the viral anti-apoptotic molecule M11L in DNA vaccine vectors enhances HIV Env-specific T cell-mediated immunity. Su J, Willert C, Comanita L, Peters A, Gilbert PA, Strathdee C, O'Connell PJ, McFadden GD, Dekaban GA, Virology 2008 375 1 48 58 10.1016/j.virol.2008.01.011 18291435
15. Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. Bellows DS, Chau BN, Lee P, Lazebnik Y, Burns WH, Hardwick JM, J Virol 2000 74 11 5024 5031 10.1128/JVI.74.11.5024-5031. 2000 10799576
16. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. Vigna E, Naldini L, J Gene Med 2000 2 5 308 316 10.1002/1521-2254(200009/10)2:5<308::AID-JGM131>3.0.CO;2-3 11045424
17. Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials. Loisel-Meyer S, Foley R, Medin JA, Front Biosci 2008 13 3202 3214 18508428
18. Tumor protection following vaccination with low doses of lentivirally transduced DCs expressing the self-antigen erbB2. Mossoba ME, Walia JS, Rasaiah VI, Buxhoeveden N, Head R, Ying C, Foley JE, Bramson JL, Fowler DH, Medin JA, Mol Ther 2008 16 3 607 617 10.1038/sj.mt.6300390 18180774
19. Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor model. Felizardo TC, Wang JC, McGray RA, Evelegh C, Spaner DE, Fowler DH, Bramson JL, Medin JA, Gene Ther 2011 18 10 986 995 10.1038/gt.2011.53 21490686
20. An essential role for Akt1 in dendritic cell function and tumor immunotherapy. Park D, Lapteva N, Seethammagari M, Slawin KM, Spencer DM, Nat Biotechnol 2006 24 12 1581 1590 10.1038/nbt1262 17143278
21. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. Shen Z, Reznikoff G, Dranoff G, Rock KL, J Immunol 1997 158 6 2723 2730 9058806
22. Autologous transplantation of lentivector/acid ceramidase-transduced hematopoietic cells in nonhuman primates. Walia JS, Neschadim A, Lopez-Perez O, Alayoubi A, Fan X, Carpentier S, Madden M, Lee CJ, Cheung F, Jaffray DA, Levade T, McCart JA, Medin JA, Hum Gene Ther 2011 22 6 679 687 10.1089/hum.2010.195 21280983
23. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Vlachos P, Nyman U, Hajji N, Joseph B, Cell Death Differ 2007 14 8 1497 1507 10.1038/sj.cdd.4402158 17464323
24. Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials. Mossoba ME, Medin JA, Expet Rev Vaccine 2006 5 5 717 732 10.1586/14760584.5.5.717
25. Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Janelsins BM, Mathers AR, Tkacheva OA, Erdos G, Shufesky WJ, Morelli AE, Larregina AT, Blood 2009 113 13 3017 3026 10.1182/blood-2008-06-163121 18987361
26. Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency. Yoshikawa T, Niwa T, Mizuguchi H, Okada N, Nakagawa S, Gene Ther 2008 15 19 1321 1329 10.1038/gt.2008.85 18480845
27. Targeting the AKT protein kinase for cancer chemoprevention. Crowell JA, Steele VE, Fay JR, Mol Canc Ther 2007 6 8 2139 2148 10.1158/1535-7163.MCT-07- 0120
28. Dendritic cells and the control of immunity. Banchereau J, Steinman RM, Nature 1998 392 6673 245 252 10.1038/32588 9521319
29. Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity. Jensen SS, Gad M, J Inflamm 2010 7 37 7 37 9255
30. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D, Nat Biotechnol 1997 15 9 871 875 10.1038/nbt0997-871 9306402
31. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D, Science 1996 272 5259 263 267 10.1126/science.272.5259.263 8602510
32. Increasing lentiviral vector titer using inhibitors of protein kinase R. Pernod G, Fish R, Liu JW, Kruithof EK, BioTechniques 2004 36 4 576-8 580 15088373
33. Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Yoshimitsu M, Sato T, Tao K, Walia JS, Rasaiah VI, Sleep GT, Murray GJ, Poeppl AG, Underwood J, West L, Brady RO, Medin JA, Proc Natl Acad Sci USA 2004 101 48 16909 16914 10.1073/pnas.0407572101 15550536
34. Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor. Opgenorth A, Graham K, Nation N, Strayer D, McFadden G, J Virol 1992 66 8 4720 4731 1629952