Factor XA activation of factor v is of paramount importance in initiating the coagulation system: Lessons from a tick salivary protein

Circulation

Volumn 128, Issue 3, 2013, Pages 254-266

  Schuijt, Tim J ^a,c   Bakhtiari, Kamran ^b   Daffre, Sirlei ^a,d   Deponte, Kathleen ^a   Wielders, Simone J H ^e   Marquart, J Arnoud ^b   Hovius, Joppe W ^a   Van Der Poll, Tom ^a   Fikrig, Erol ^a   Bunce, Matthew W ^g   Camire, Rodney M ^g   Nicolaes, Gerry A F ^f   Meijers, Joost C M ^b   Van 'T Veer, Cornelis ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Department of Experimental Vascular Medicine ^*  (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Anticoagulants; Blood coagulation; Ticks

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; SALIVA PROTEIN; THROMBIN; TIX 5 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVATION; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TICK;

ANTICOAGULANTS; BLOOD COAGULATION; TICKS;

ANIMALS; ANTICOAGULANTS; ARTHROPOD PROTEINS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR V; FACTOR XA; FEEDING BEHAVIOR; FIBRINOGEN; HUMANS; IXODES; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECOMBINANT PROTEINS; SALIVARY PROTEINS AND PEPTIDES; SURFACE PLASMON RESONANCE; THROMBIN;

EID: 84880329348     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.003191     Document Type: Article

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