Na/Ca exchange and contraction of the heart

Journal of Molecular and Cellular Cardiology

Volumn 61, Issue , 2013, Pages 28-33

  Ottolia, Michela ^a   Torres, Natalia ^b   Bridge, John H B ^b   Philipson, Kenneth D ^c   Goldhaber, Joshua I ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium; Excitation contraction coupling; Genetically modified mice; Heart contractility; Heart failure; Sodium calcium exchanger

Indexed keywords

CALCIUM; DIGITALIS; DIGOXIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DRUG MECHANISM; EXCITATION CONTRACTION COUPLING; HEART CONTRACTION; HEART FAILURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE;

ACTION POTENTIAL; AP; CA; CALCIUM; EC; EXCITATION CONTRACTION COUPLING; EXCITATION-CONTRACTION COUPLING; GENETICALLY MODIFIED MICE; HEART CONTRACTILITY; HEART FAILURE; KO; L-TYPE CA CHANNELS; LCCS; NCX; NCX KNOCKOUT MOUSE; RYANODINE RECEPTOR; RYRS; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGER; SR;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; CELL MEMBRANE STRUCTURES; EXCITATION CONTRACTION COUPLING; HEART FAILURE; HUMANS; MYOCARDIAL CONTRACTION; SARCOPLASMIC RETICULUM; SODIUM; SODIUM-CALCIUM EXCHANGER;

MUS;

EID: 84880325514     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.06.001     Document Type: Review

References (77)

1. 2+ exchanger, NCX1. J Mol Cell Cardiol 2013, 57:68-71.
2. Liao J., Li H., Zeng W., Sauer D.B., Belmares R., Jiang Y. Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science 2012, 335:686-690.
3. 2+ exchanger. J Biol Chem 2009, 284:32735-32741.
4. Matsuoka S., Hilgemann D.W. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle. J Gen Physiol 1992, 100:963-1001.
5. 2+ exchanger dimers. Proc Natl Acad Sci U S A 2011, 108:1699-1704.
6. 2+ exchanger proteins: evidence for dimer formation. Biochemistry 2008, 47:6081-6087.
7. 2+ exchanger and ryanodine receptor during development. Biophys J 2007, 93:2504-2518.
8. 2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study. J Cell Biol 1992, 117:337-345.
9. Sipido K.R., Acsai K., Antoons G., Bito V., Macquaide N. T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange. Adv Exp Med Biol 2013, 961:375-383.
10. Blaustein M.P., Lederer W.J. Sodium/calcium exchange: its physiological implications. Physiol Rev 1999, 79:763-854.
11. Wier W.G., Egan T.M., Lopez-Lopez J.R., Balke C.W. Local control of excitation-contraction coupling in rat heart cells. J Physiol 1994, 474:463-471.
12. Na-Ca in cardiac myocytes. Science 1990, 248:376-378.
13. Dedkova E.N., Blatter L.A. Calcium signaling in cardiac mitochondria. J Mol Cell Cardiol 2013, 58:125-133.
14. Bassani J.W., Yuan W., Bers D.M. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol 1995, 268:C1313-C1319.
15. Shannon T.R., Ginsburg K.S., Bers D.M. Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration. Biophys J 2000, 78:334-343.
16. Shattock M.J., Bers D.M. Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes. Am J Physiol 1989, 256:C813-C822.
17. Goldhaber J.I., Hamilton M.A. Role of inotropic agents in the treatment of heart failure. Circulation 2010, 121:1655-1660.
18. Goldhaber J.I., Philipson K.D. Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease. Adv Exp Med Biol 2013, 961:355-364.
19. 2+ exchanger in end-stage human heart failure. Circ Res 1994, 75:443-453.
20. 2+ transient of failing human ventricular myocytes. Circ Res 1999, 84:435-444.
21. 2+ exchange activity in canine pacing-induced heart failure. Circ Res 2000, 87:690-698.
22. 2+ exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis. Circulation 2000, 102:2137-2144.
23. 2+ exchanger remodeling in pressure overload cardiac hypertrophy. J Biol Chem 2001, 276:17706-17711.
24. O'Rourke B., Kass D.A., Tomaselli G.F., Kääb S., Tunin R., Marbán E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. Circ Res 1999, 84:562-570.
25. Marks A.R. Cardiac intracellular calcium release channels: role in heart failure. Circ Res 2000, 87:8-11.
26. 2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol 2007, 292:H1607-H1618.
27. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 1999, 85:1009-1019. [See comments].
28. Langer G.A. Effects of digitalis on myocardial ionic exchange. Circulation 1972, 4(6):180-187.
29. Smith T.W. Digitalis: mechanisms of action and clinical use. N Engl J Med 1988, 318:358-365.
30. 2+ overload in rat ventricular myocytes. Circulation 2000, 101:1441-1446.
31. 2+ exchanger function. J Physiol 2006, 575:845-854.
32. Ozdemir S., Bito V., Holemans P., Vinet L., Mercadier J.J., Varro A., et al. Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block. Circ Res 2008, 102:1398-1405.
33. 2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol 2009, 76:560-568.
34. 2+ exchange inhibitors. Circ Res 2002, 91:90-92.
35. Sagawa T., Sagawa K., Kelly J.E., Tsushima R.G., Wasserstrom J.A. Activation of cardiac ryanodine receptors by cardiac glycosides. Am J Physiol Heart Circ Physiol 2002, 282:H1118-H1126.
36. 2+ exchanger is essential for the action of cardiac glycosides. Circ Res 2002, 90:305-308.
37. 2+ exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res 2003, 57:974-985.
38. 2+ exchanger. J Gen Physiol 1997, 109:717-729.
39. 2+ exchanger. J Physiol 1998, 512:651-667.
40. 2+]i transients in murine ventricular myocytes. Circ Res 1998, 82:657-665.
41. 2+ content in adult rat myocytes. Am J Physiol Heart Circ Physiol 2001, 281:H2079-H2088.
42. 2+ contents, and action potential duration. Am J Physiol Heart Circ Physiol 2009, 297:H590-H601.
43. Reuter H., Han T., Motter C., Philipson K.D., Goldhaber J.I. Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. J Physiol 2004, 554:779-789.
44. Roos K.P., Jordan M.C., Fishbein M.C., Ritter M.R., Friedlander M., Chang H.C., et al. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Card Fail 2007, 13:318-329.
45. Gomez A.M., Valdivia H.H., Cheng H., Lederer M.R., Santana L.F., Cannell M.B., et al. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 1997, 276:800-806. [See comments].
46. Piacentino V., Weber C.R., Chen X., Weisser-Thomas J., Margulies K.B., Bers D.M., et al. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res 2003, 92:651-658.
47. Sachse F.B., Torres N.S., Savio-Galimberti E., Aiba T., Kass D.A., Tomaselli G.F., et al. Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. Circ Res 2012, 110:588-597.
48. 2+ exchange: cardiac-specific knockout of NCX1. Circ Res 2004, 95:604-611.
49. Shai S.Y., Harpf A.E., Babbitt C.J., Jordan M.C., Fishbein M.C., Chen J., et al. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 2002, 90:458-464.
50. Gutstein D.E., Morley G.E., Fishman G.I. Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart. Cell Commun Adhes 2001, 8:345-348.
51. Jordan M.C., Henderson S.A., Han T., Fishbein M.C., Philipson K.D., Roos K.P. Myocardial function with reduced expression of the sodium-calcium exchanger. J Card Fail 2010, 16:786-796.
52. 2+ flux. Circ Res 2005, 97:1288-1295.
53. 2+ exchanger. Biophys J 2007, 92:1431-1437.
54. Neco P., Rose B., Huynh N., Zhang R., Bridge J.H., Philipson K.D., et al. Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophys J 2010, 99:755-764.
55. 2+ gating of skeletal muscle and cardiac ryanodine receptors. Biophys J 1997, 73:141-156.
56. LeBlanc N., Hume J.R. Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science 1990, 248:372-376.
57. Nuss H.B., Houser S.R. Sodium-calcium exchange-mediated contractions in feline ventricular myocytes. Am J Physiol 1992, 263:H1161-H1169.
58. Kohmoto O., Levi A.J., Bridge J.H.B. Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res 1994, 74:550-554.
59. Levi A.J., Spitzer K.W., Kohmoto O., Bridge J.H.B. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am J Physiol 1994, 266:H1422-H1433.
60. 2+ exchange in activation of excitation-contraction coupling in rat ventricular myocytes. J Physiol (Lond) 1996, 493:529-542.
61. Litwin S.E., Li J., Bridge J.H. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophys J 1998, 75:359-371.
62. 2+ release in ventricular myocytes. Biophys J 2008, 94:L54-L56.
63. 2+ exchange. Circ Res 1997, 81:1034-1044.
64. Weber C.R., Piacentino V., Houser S.R., Bers D.M. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation 2003, 108:2224-2229.
65. 2+] during the cardiac action potential. Circ Res 2002, 90:182-189.
66. 2+ transient: evidence from NCX knockout mice. J Physiol 2010, 588:3267-3276.
67. 2+ release from the sarcoplasmic reticulum. J Physiol 2010, 588:4249-4260.
68. Bers D.M. Excitation-contraction coupling and cardiac contractile force 1991, Kluwer Academic Publishers, Boston.
69. Catterall W.A., Goldin A.L., Waxman S.G. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 2005, 57:397-409.
70. Goldin A.L. Resurgence of sodium channel research. Annu Rev Physiol 2001, 63:871-894.
71. + channel isoform. Proc Natl Acad Sci U S A 1989, 86:8170-8174.
72. Na is greater in dog heart Purkinje fibers than in ventricles. Cardiovasc Res 2005, 65:117-127.
73. + channels. FEBS Lett 1990, 275:195-200.
74. 2+ exchanger in rabbit cardiomyocytes during development. Am J Physiol Heart Circ Physiol 2011, 300:H300-H311.
75. Maier S.K., Westenbroek R.E., McCormick K.A., Curtis R., Scheuer T., Catterall W.A. Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 2004, 109:1421-1427.
76. 2+ release in cardiomyocytes. Biophys J 2006, 91:779-792.
77. Brette F., Orchard C.H. No apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytes. Circ Res 2006, 98:667-674.