Mesenchymal stromal cells in inflammatory bowel disease: Conspirators within the 'colitogenic niche'?

Gut

Volumn 62, Issue 8, 2013, Pages 1098-1099

  Danese, Silvio ^a   Rutella, Sergio ^b   Vetrano, Stefania ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTING CELL; BONE MARROW MESENCHYMAL STROMA CELL; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; COLITIS; CROHN DISEASE; CYTOKINE PRODUCTION; HUMAN; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MESENCHYMAL STROMA CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STEM CELL NICHE;

INFLAMMATORY BOWEL DISEASE;

ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; COLITIS, ULCERATIVE; INTERLEUKIN-7; MESENCHYMAL STROMAL CELLS;

EID: 84880323266     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303903     Document Type: Note

References (10)

1. Nemoto Y, Kanai T, Takahara M, et al. Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells. Gut 2013;62:1143-53.
2. Bernardo ME, Locatelli F, Fibbe WE. Mesenchymal stromal cells. Ann N Y Acad Sci 2009;1176: 101-17.
3. Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 2012;12:383-96.
4. Ghannam S, Pene J, Torcy-Moquet G, et al. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 2010;185:302-12.
5. Ciccocioppo R, Bernardo ME, Sgarella A, et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011;60:788-98.
6. Duijvestein M, Vos AC, Roelofs H, et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 2010;59:1662-9.
7. Nemoto Y, Kanai T, Makita S, et al. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology 2007;132:176-89.
8. Nemoto Y, Kanai T, Shinohara T, et al. Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology 2011;141:2130-9e11.
9. Heninger AK, Theil A, Wilhelm C, et al. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol 2012;189:5649-58.
10. Penaranda C, Kuswanto W, Hofmann J, et al. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci USA 2012;109:12668-73.