Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

Gut

Volumn 62, Issue 8, 2013, Pages 1142-1152

  Nemoto, Yasuhiro ^a   Kanai, Takanori ^b   Takahara, Masahiro ^a   Oshima, Shigeru ^a   Nakamura, Tetsuya ^a   Okamoto, Ryuichi ^a   Tsuchiya, Kiichiro ^a   Watanabe, Mamoru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45RB ANTIGEN; INTERLEUKIN 7; PROTEIN BCL 2; RAG1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; COLITIS; COLITOGENIC MEMORY CD4 T CELL; COLON; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL NICHE; TISSUE SPECIFICITY; UPREGULATION;

IBD BASIC RESEARCH; IMMUNOLOGY; T LYMPHOCYTES;

ADOPTIVE TRANSFER; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; COLITIS, ULCERATIVE; COLON; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IMMUNOLOGIC MEMORY; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER;

EID: 84880278485     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-302029     Document Type: Article

References (25)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427-34.
2. Gattinoni L, Lugli E, Ji Y, et al. A human memory T cell subset with stem cell-like properties. Nat Med 2011;17:1290-7.
3. Kanai T, Nemoto Y, Tomita T, et al. Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable. Inflamm Bowel Dis 2009;5:926-34.
4. Sprent J, Surh CD. T cell memory. Annu Rev Immunol 2002;20:551-79.
5. Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 2003;4:680-6.
6. Schluns KS, Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 2003;3:269-79.
7. Namen AE, Lupton S, Hjerrild K, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 1988;333:571-3.
8. Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 1995;95:2945-53.
9. Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 1998;187:389-402.
10. Yamazaki M, Yajima T, Tanabe M, et al. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J Immunol 2003;171:1556-63.
11. Totsuka T, Kanai T, Nemoto Y, et al. IL-7 is essential for the development and the persistence of chronic colitis. J Immunol 2007;178;4737-48.
12. Tomita T, Kanai T, Nemoto Y, et al. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol 2008;180:383-90.
13. Makita S, Kanai T, Nemoto Y, et al. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol 2007;178:4937-46.
14. Di Rosa F, Pabst R. The bone marrow: a nest for migratory memory T cells. Trends Immunol 2005;26:360-6.
15. Tokoyoda K, Hauser AE, Nakayama T, et al. Organization of immunological memory by bone marrow stroma. Nat Rev Immunol 2010;10:193-200.
16. Nemoto Y, Kanai T, Makita S, et al. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology 2007;132;176-89.
17. Nemoto Y, Kanai T, Kameyama K, et al. Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J Immunol 2009;183:5059-68.
18. Nemoto Y, Kanai T, Shinohara T, et al. Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology 2011;141:2130-9.
19. Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008;8:726-36.
20. Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 2009;4:206-16.
21. Sasaki M, Abe R, Fujita Y, et al. Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008;180:2581-7.
22. Wherry EJ, Barber DL, Kaech SM, et al. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A 2004;101:16004-9.
23. Duijvestein M, Vos AC, Roelofs H, et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 2010;59:1662-9.
24. Watanabe M, Watanabe N, Iwao Y, et al. The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7. J Clin Immunol 1997;17:282-92.
25. Rivas MA, Beaudoin M, Gardet A, et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet 2011;43:1066-73.