Boosting salt resistance of short antimicrobial peptides

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 4050-4052

  Chu, Hung Lun ^a   Yu, Hui Yuan ^a   Yip, Bak Sau ^a,b   Chih, Ya Han ^a   Liang, Chong Wen ^a   Cheng, Hsi Tsung ^a   Cheng, Jya Wei ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; AMINO ACID; BETA NAPHTHYLALANINE; POLYPEPTIDE ANTIBIOTIC AGENT; SODIUM CHLORIDE; TRYPTOPHAN DERIVATIVE; TRYPTOPHAN RICH PEPTIDE S1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMPICILLIN; ANTI-INFECTIVE AGENTS; BETA-ALANINE; DRUG STABILITY; ERYTHROCYTES; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; PEPTIDES; SERUM; SODIUM CHLORIDE; TRYPTOPHAN;

EID: 84880318497     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00252-13     Document Type: Article

References (25)

1. Zasloff M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389-395.
2. Hancock REW, Sahl HG. 2006. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotechnol. 24:1551-1557.
3. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. 1997. Human-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560.
4. Lee IH, Cho Y, Lehrer RI. 1997. Effects of pH and salinity on the antimicrobial properties of clavanins. Infect. Immun. 65:2898-2903.
5. Rothstein DM, Spacciapoli P, Tran LT, Xu T, Roberts FD, Dalla Serra M, Buxton DK, Oppenheim FG, Friden P. 2001. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin5 Antimcrob. Agents Chemother. 45:1367-1373.
6. Wang CW, Yip BS, Cheng HT, Wang AH, Chen HL, Cheng JW, Lo HJ. 2009. Increased potency of a novel D-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens. FEMS Yeast Res. 9:967-970.
7. Wu M, Maier E, Benz R, Hancock REW. 1999. Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Biochemistry 38: 7235-7242.
8. Deslousches B, Phadke SM, Lazarevic V, Cascio M, Islam K, Montelaro RC, Mietzner TA. 2005. De novo generation of cationic antimicrobial peptides: influence of length and tryptophan substitution on antimicrobial activity. Antimcrob. Agents Chemother. 49:316-322.
9. Friedrich C, Scott MG, Karunaratne N, Yan H, Hancock REW. 1999. Salt-resistant alpha-helical cationic antimicrobial peptides. Antimcrob. Agents Chemother. 43:1542-1548.
10. Harwig SSL, Waring A, Yang HJ, Cho Y, Tan L, Lehrer RI. 1996. Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur. J. Biochem. 240:352-357.
11. Park IY, Cho JH, Kim KS, Kim YB, Kim MS, Kim SC. 2004. Helix stability confers salt resistance upon helical antimicrobial peptides. J. Biol. Chem. 279:13896-13901.
12. Rydlo T, Rotem S, Mor A. 2006. Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions. Antimcrob. Agents Chemother. 50:490-497.
13. Tam JP, Lu YA, Yang JL. 2000. Design of salt-insensitive glycine-rich antimicrobial peptides with cyclic tricystine structures. Biochemistry 39: 7159-7169.
14. Yu HY, Tu CH, Yip BS, Chen HL, Cheng HT, Huang KC, Lo HJ, Cheng JW. 2011. Easy strategy to increase salt resistance of antimicrobial peptides. Antimcrob. Agents Chemother. 55:4918-4921.
15. Yu HY, Huang KC, Yip BS, Chen HTCHL, Cheng HT, Cheng JW. 2010. Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities. Chembiochem 11:2273-2282.
16. Pasupuleti M, Chalupka A, Morgelin M, Schmidtchen A, Malmsten M. 2009. Tryptophan end-tagging of antimicrobial peptides for increased potency against Pseudomonas aeruginosa. Biochim. Biophys. Acta 1790:800-808.
17. Pasupuleti M, Schmidtchen A, Chalupka A, Ringstad L, Malmsten M. 2009. End-tagging of ultra-short antimicrobial peptides by W/F stretches to facilitate bacterial killing. PLoS One 4:e5285. doi:10.1371/journal.pone .0005285.
18. Schmidtchen A, Pasupuleti M, Morgelin M, Davoudi M, Alenfall J, Chalupka A, Malmsten M. 2009. Boosting antimicrobial peptides by hydrophobic oligopeptide end tags. J. Biol. Chem. 284:17584-17594.
19. Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y. 2012. Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B. Antimcrob. Agents Chemother. 56:1-9.
20. Avrahami D, Shai Y. 2002. Conjugation of a magainin analogue with lipophilic acids controls hydrophobicity, solution assembly, and cell selectivity. Biochemistry 41:2254-2263.
21. Makovitzki A, Avrahami D, Shai Y. 2006. Ultrashort antibacterial and antifungal lipopeptides. Proc. Natl. Acad. Sci. U. S. A. 103:15997-16002.
22. Rosenfeld Y, Lev N, Shai Y. 2010. Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides. Biochemistry 49:853-861.
23. Serrano GN, Zhanel GG, Schweizer F. 2009. Antibacterial activity of ultrashort cationic lipo-peptides. Antimcrob. Agents Chemother. 53: 2215-2217.
24. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. U. S. A. 95:14863-14868.
25. Wei SY, Wu JM, Kuo YY, Chen HL, Yip BS, Tzeng SR, Cheng JW. 2006. Solution structure of a novel tryptophan-rich peptide with bidirectional antimicrobial activity. J. Bacteriol. 188:328-334.