Easy strategy to increase salt resistance of antimicrobial peptides

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 10, 2011, Pages 4918-4921

  Yu, Hui Yuan ^a   Tu, Chih Hsiung ^a   Yip, Bak Sau ^a,b   Chen, Heng Li ^a   Cheng, Hsi Tsung ^a   Huang, Kuo Chun ^a   Lo, Hsiu Jung ^c   Cheng, Jya Wei ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTENECIN; BETA (4,4' BIPHENYL)ALANINE; BETA DEFENSIN 1; BETA NAPHTHYLALANINE; GRAMICIDIN; HISTIDINE; INDOLICIDIN; MAGAININ 1; POLYPEPTIDE ANTIBIOTIC AGENT; SARALASIN; SODIUM CHLORIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; CYSTIC FIBROSIS; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ALANINE; BACTERIA; BETA-ALANINE; BIPHENYL COMPOUNDS; CANDIDA; HISTATINS; MICROBIAL SENSITIVITY TESTS; SALINITY; SALT-TOLERANCE; SODIUM CHLORIDE;

EID: 80052850847     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00202-11     Document Type: Article

References (22)

1. Deslousches, B., et al. 2005. Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: implications for systemic applications. Antimicrob. Agents Chemother. 49:3208-3216.
2. Deslousches, B., et al. 2005. De novo generation of cationic antimicrobial peptides: influence of length and tryptophan substitution on antimicrobial activity. Antimicrob. Agents Chemother. 49:316-322.
3. Friedrich, C., M. G. Scott, N. Karunaratne, H. Yan, and R. E. W. Hancock. 1999. Salt-resistant alpha-helical cationic antimicrobial peptides. Antimicrob. Agents Chemother. 43:1542-1548.
4. Goldman, M. J., et al. 1997. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560. (Pubitemid 27154420)
5. Hancock, R. E. W., and H. G. Sahl. 2006. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat. Biotech. 24:1551-1557.
6. Harwig, S. S. L., et al. 1996. Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur. J. Biochem. 240:352-357.
7. Haug, B. E., M. L. Skar, and J. S. Svendsen. 2001. Bulky aromatic amino acids increase the antibacterial activity of 15-residue bovine lactoferricin derivatives. J. Pept. Sci. 7:425-432.
8. Helmerhorst, E. J., F. G. Oppenheim, L. Choi, J. W. Cheng, and N. E. Reiner. 2007. Evaluation of a new host-derived synthetic antifungal peptide (PAC-113) in the treatment of oral candidiasis. Int. Meet. Antimicrob. Chemother. Clin. Pract. Italy, poster 9.
9. Helmerhorst, E. J., W. Van T. Hof, E. C. I. Veerman, I. Simmons-Smit, and A. V. Nieuw Amerongen. 1997. Synthetic histatin analogues with broadspectrum antimicrobial activity. Biochem. J. 326:39-45.
10. Jang, W. S., X. S. Li, J. N. Sun, and M. Edgerton. 2008. The P-113 fragment of histatin 5 requires a specific peptide sequence for intracellular translocation in Candida albicans, which is independent of cell wall binding. Antimicrob. Agents Chemother. 52:497-504.
11. Koshlukova, S. E., T. L. Lloyd, M. W. B. Araujo, and M. Edgerton. 1999. Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death. J. Biol. Chem. 274:18872-18879.
12. Lee, I. H., Y. Cho, and R. I. Lehrer. 1997. Effects of pH and salinity on the antimicrobial properties of clavanins. Infect. Immun. 65:2898-2903.
13. Park, I. Y., et al. 2004. Helix stability confers salt resistance upon helical antimicrobial peptides. J. Biol. Chem. 279:13896-13901.
14. Rothstein, D. M., et al. 2001. Anti-Candida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Antimicrob. Agents Chemother. 45:1367-1373.
15. Rydlo, T., S. Rotem, and A. Mor. 2006. Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions. Antimicrob. Agents Chemother. 50:490-497.
16. Tam, J. P., Y. A. Lu, and J. L. Yang. 2000. Design of salt-insensitive glycine-rich antimicrobial peptides with cyclic tricystine structures. Biochemistry 39:7159-7169.
17. Wang, C. W., et al. 2009. Increased potency of a novel D-beta-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens. FEMS Yeast Res. 9:967-970.
18. Wei, S. Y., et al. 2006. Solution structure of a novel tryptophan-rich peptide with bidirectional antimicrobial activity. J. Bacteriol. 188:328-334.
19. Wu, J. M., et al. 2007. Solution structure of a novel D-naphthylalanine substituted peptide with potential antibacterial and antifungal activities. Biopolymers 88:738-745.
20. Wu, M., E. Maier, R. Benz, and R. E. W. Hancock. 1999. Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli. Biochemistry 38:7235-7242.
21. Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415:389-395. (Pubitemid 34100944)
22. Zhang, L., et al. 2005. Antimicrobial peptide therapeutics for cystic fibrosis. Antimicrob. Agents Chemother. 49:2921-2927.