PHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute basic research

Clinical Orthopaedics and Related Research

Volumn 471, Issue 8, 2013, Pages 2540-2547

  Li, Xinning ^a   Xu, Jianwen ^a   Filion, Tera M ^a   Ayers, David C ^a   Song, Jie ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYAPATITE; PHOSPHATE BUFFERED SALINE; POLYMACON; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; BONE DEVELOPMENT; BONE GRAFT; BONE STRUCTURE; CELL TRANSDIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RELEASE; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SCANNING ELECTRON MICROSCOPY;

EID: 84880316328     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-012-2644-5     Document Type: Conference Paper

References (42)

1. Abrarrategi A, Moreno-Vincent C, Ramos V, Aranaz L, Sanz Casado JV, Lopez-Lacomba JL. Improvement of porous beta-TCP scaffolds with rhBMP-2 choitosan carrier film for bone tissure application. Tissue Eng Part A. 2008;14:1305-1319.
2. Anderson EM, Noble ML, Garty S, Ma HY, Bryers JD, Shen TT, Ratner BD. Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery. Biomaterials. 2009;30:5675-5681.
3. Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA. Complications of iliac crest bone graft. Clin Orthop Relat Res. 1996;329:300-309.
4. Bostrom MP, Camacho NP. Potential role of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res. 1998;355(suppl):S274-S282.
5. Bostrom MP, Seigerman DA. The clinical use of allografts, demineralized bone matricies, synthetic bone graft substitutes and osteoinductive growth factors: a survey study. HSS J. 2005;1:9-18.
6. Bourque WT, Gross M, Hall BK. A reproducible method for producing and quantifying the stages of fracture repair. Lab Anim Sci. 1992;42:369-374.
7. Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011;11:471-491.
8. Clellan J, Mulconrey D, Forbes R, Fullmer N. Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2). J Spinal Disord Tech. 2006;19:483-486.
9. Decoster TA, Gehlert RJ, Mikola EA, Pirela-Cruz MA. Management of posttraumatic segmental bone defects. J Am Acad Orthop Surg. 2004;12:28-38.
10. Delloye C, Cornu O, Druez V, Barbier O. Bone allografts: what they can offer and what they cannot. J Bone Joint Surg Br. 2007;89:574-580.
11. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elasteromeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011;17:503-511.
12. Gilbert M, Shaw WJ, Long JR, Nelson K, Drobny GP, Giachelli CM, Stayton PS. Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion. J Biol Chem. 2000;275:16213-16218.
13. Glassman SD, Howard J, Dimar J, Sweet A, Wilson G, Carreon L. Complications with rhBMP-2 in posterolateral spine fusion: a consecutive series of one thousand thirty-seven cases. Spine (Phila Pa 1976). 2011;36:1849-1854.
14. Hanssen AD, Spangehl MJ. Practical applications of antibiotic-loaded bone cement for treatment of infected joint replacement. Clin Orthop Relat Res. 2004;427:79-85.
15. Jeon O, Song SJ, Kang SW, Putnam AJ, Kim BS. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a herparin conjugated poly(l-lactic-co-glycolic acid) scaffold. Biomaterials. 2007;28:2763-2771.
16. Jones AL. Recombinant human bone morphogenic protein-2 in fracture care. J Orthop Trauma. 2005;19(10 suppl):S23-S25.
17. Katagiri T, Yamaguchi A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol. 1994;127:1755-1766.
18. Kempen DH, Kruyt MC, Lu L, Wilson CE, Florschutz AV, Creemers LB, Yaszemski MJ, Dhert WJ. Effect of autogous BMSCs seeding and BMP-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite. Tissue Eng Part A. 2008;15:587-594.
19. Kim SS, Gwak SJ, Sim BS. Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulate and bone morphogenetic protein-2. J Biomed Mater Res A. 2008;87:245-253.
20. Lee SH, Lee JE, Baek WY, Lim JO. Regional delivery of vancomycin using pluronic F-127 to inhibit methicillin resistant Staphylococcus aureus (MRSA) growth in chronic otitis media in vitro and in vivo. J Control Release. 2004;96:1-7.
21. Le Nihouannen D, Hacking SA, Gbureck U, Komarova SV, Barralet JE. The use of RANKL-coated brushite cement to stimulate bone remodelling. Biomaterials. 2008;29:3253-3259.
22. Li B, Brown KV, Wenke JC, Guelcher SA. Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model. J Control Release. 2010;145:221-230.
23. McCall TA, Brokaw DS, Jelen BA, Scheid KD, Scharfenberger AV, Maar DC, Green JM, Shipps MR, Stone MB, Musapatika D, Weber TG. Treatment of large segmental bone defects with reamer irrigator-aspirator bone graft: technique and case series. Orthop Clin North Am. 2010;41:63-73.
24. McKay B, Sandhu HS. Use of recombinant human bone morphogenetic protein-2 in spinal fusion. Spine (Phila Pa 1976). 2002;27(16 suppl 1):S66-S85.
25. Montgomery DM, Aronson DD, Lee CL, LaMont RL. Posterior spinal fusion: allograft versus autograft bone. J Spinal Disord Tech. 1990;3:370-375.
26. Moore AR, Graves SE, Bain GI. Synthetic bone graft substitutes. ANZ J Surg. 2001;71:354-361.
27. Muscolo D, Ayerza M, Aponte-Tinao L. Massive allograft use in orthopedic oncology. Orthop Clinic North Am. 2006;37:65-74.
28. Naraghi F, Wolfer L, Lewis M, Palma C. BMP-2 dose correlates with increase postoperative edema and swallowing complications after cervical fusion. Spine J. 2006;6:7s-8s.
29. Ozaki T, Hillmann A, Bettin D, Wuisman P, Winkelmann W. Intramedullary, antibiotic-loaded cemented, massive allografts for skeletal reconstruction: 26 cases compared with 19 uncemented allografts. Acta Orthop Scand. 1997;68:387-391.
30. Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone cement. J Arthroplasty. 1996;11:939-944.
31. Prokuski L. Prophylactic antibiotics in orthopaedic surgery. J Am Acad Orthop Surg. 2008;16:283-293.
32. Raiche AT, Puleo DA. Cell responses to BMP-2 and IGF-I release with different time-dependent profiles. J Biomed Mater Res A. 2004;69:342-350.
33. Rauschmann MA, Wichelhaus TA, Stirnal V, Dingeldein E, Zichner L, Schnettler R, Volker A. Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections. Biomaterials. 2005;26:2677-2684.
34. Shah RK, Moncayo VM, Smitson RD, Pierre-Jerome C, Terk MR. Recombinant human bone morphogenetic protein 2 induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion. Skeletal Radiol. 2010;39:501-504.
35. Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB. Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine (Phila Pa 1976). 2006;31:542-547.
36. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian J, Stein GS, Ayers D, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009;89:1098-1107.
37. Stubbs JT 3rd, Mintz KP, Eanes ED, Torchia DA, Fisher LW. Characterization of native and recombinant bone sialoprotein: delineation of the mineral-binding and cell adhesion domains and structural analysis of the RGD domain. J Bone Miner Res. 1997;12:1210-1222.
38. Su A, Chen W, Chen C, Chen T. Innovative trident fixation technique for allograft knee arthrodesis for high-grade osteosarcoma around the knee. Jpn J Clin Oncol. 2009;39:739-744.
39. Whitehouse MR, Lankester BJ, Winson IG, Hepple S. Bone graft harvest from the proximal tibia in foot and ankle arthrodesis surgery. Foot Ankle Int. 2006;27:913-916.
40. Wong D, Kumar A, Jatana S, Ghiselli G, Wong K. Neurologic impairment from ectopic bone in the lumbar canal: a potential complications of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J. 2008;8:1011-1018.
41. Wood M. Wrist arthrodesis using dorsal radial bone graft. J Hand Surg Am. 1987;12:208-212.
42. Xu J, Li X, Lian J, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009;27:1306-1311.