Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 3659-3666

  Zhang, Lu ^a   Huang, Ying ^a   Zhou, Yang ^a   Buckley, Timothy ^a,b   Wang, Hua H ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MEGADOSE; ENTEROCOCCUS; ESCHERICHIA COLI; GASTROINTESTINAL TRACT; GENE POOL; INTESTINE FLORA; LIMIT OF DETECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADMINISTRATION, ORAL; AMPICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; DRUG ADMINISTRATION ROUTES; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; ESCHERICHIA COLI; FECES; GASTROINTESTINAL TRACT; GENES, BACTERIAL; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED C57BL; MICROBIOTA; MODELS, ANIMAL; TETRACYCLINE;

EID: 84880311835     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00670-13     Document Type: Article

References (38)

1. Casewell M, Friis C, Marco E, McMullin P, Phillips I. 2003. The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J. Antimicrob. Chemother. 52: 159-161.
2. Tenover FC, McGowan JE, Jr. 1996. Reasons for the emergence of antibiotic resistance. Am. J. Med. Sci. 311:9-16.
3. Wang H, McEntire JC, Zhang L, Li X, Doyle M. 2012. The transfer of antibiotic resistance from food to humans: facts, implications and future directions. Rev. Sci. Tech. 31:249-260.
4. Wang HH. 2009. Commensal bacteria, microbial ecosystems and horizontal gene transmission: adjusting our focus for strategic breakthroughs against antibiotic resistance, p 267-281. In Jaykus L, Wang HH, Schlesinger L (ed), Foodborne microbes: shaping the host ecosystems, 1st ed. ASM Press, Washington, DC.
5. Jacoby GA. 2005. Mechanisms of resistance to quinolones. Clin. Infect. Dis. 41(Suppl. 2):S120-S126.
6. Poole K. 2005. Efflux-mediated antimicrobial resistance. J. Antimicrob. Chemother. 56:20-51.
7. Stein T, Heinzmann S, Solovieva I, Entian K. 2003. Function of Lactococcus lactis nisin immunity genes nisI and nisFEG after coordinated expression in the surrogate host Bacillus subtilis. J. Biol. Chem. 278:89-94.
8. Livermore DM. 2000. Antibiotic resistance in staphylococci. Int. J. Antimicrob. Agents 16(Suppl. 1):S3-S10.
9. Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J. 2010. Call of the wild: antibiotic resistance genes in natural environments. Nat. Rev. Microbiol. 8:251-259.
10. Duran GM, Marshall DL. 2005. Ready-to-eat shrimp as an international vehicle of antibiotic-resistant bacteria. J. Food Prot. 68:2395-2401.
11. Li X, Alvarez V, Harper WJ, Wang HH. 2011. Persistent, toxin-antitoxin system-independent, tetracycline resistance-encoding plasmid from a dairy Enterococcus faecium isolate. Appl. Environ. Microbiol. 77:7096-7103.
12. Wang HH, Manuzon M, Lehman M, Wan K, Luo H, Wittum TE, Yousef A, Bakaletz LO. 2006. Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes. FEMS Microbiol. Lett. 254:226-231.
13. Luo H, Wan K, Wang HH. 2005. High-frequency conjugation system facilitates biofilm formation and pAMbeta1 transmission by Lactococcus lactis. Appl. Environ. Microbiol. 71:2970-2978.
14. Kinkelaar D, Wang H. 2008. Profiles of tetracycline resistant bacteria in the human infant digestive system. Masters thesis. The Ohio State University, Columbus, OH.
15. Zhang L, Kinkelaar D, Huang Y, Li Y, Li X, Wang HH. 2011. Acquired antibiotic resistance: are we born with it?. Appl. Environ. Microbiol. 77: 7134-7141.
16. Stanton TB, Humphrey SB, Stoffregen WC. 2011. Chlortetracyclineresistant intestinal bacteria in organically raised and feral swine. Appl. Environ. Microbiol. 77:7167-7170.
17. Zhang L, Wang H. 2011. Establishment and development of antibiotic resistant bacteria in human gastrointestinal tract: food, drug, or are we born with it?. PhD dissertation. The Ohio State University, Columbus, OH.
18. Nguyen T, Hamby A, Massa SM. 2005. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc. Natl. Acad. Sci. U. S. A. 102:11840-11845.
19. Belur LR, Podetz-Pedersen K, Frandsen J, McIvor RS. 2007. Lungdirected gene therapy in mice using the nonviral Sleeping Beauty transposon system. Nat. Protoc. 2:3146-3152.
20. Yu Z, Morrison M. 2004. Improved extraction of PCR-quality community DNA from digesta and fecal samples. Biotechniques 36:808-812.
21. Manuzon MY, Hanna SE, Luo H, Yu Z, Harper WJ, Wang HH. 2007. Quantitative assessment of the tetracycline resistance gene pool in cheese samples by real-time TaqMan PCR. Appl. Environ. Microbiol. 73:1676-1677.
22. Muyzer G, de Waal EC, Uitterlinden AG. 1993. Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. Appl. Environ. Microbiol. 59:695-700.
23. Bartoloni A, Bartalesi F, Mantella A, Dell'Amico E, Roselli M, Strohmeyer M, Barahona HG, Barron VP, Paradisi F, Rossolini GM. 2004. High prevalence of acquired antimicrobial resistance unrelated to heavy antimicrobial consumption. J. Infect. Dis. 189:1291-1294.
24. Gilliver MA, Bennett M, Begon M, Hazel SM, Hart CA. 1999. Antibiotic resistance found in wild rodents. Nature 401:233-234.
25. Gueimonde M, Salminen S, Isolauri E. 2006. Presence of specific antibiotic (tet) resistance genes in infant faecal microbiota. FEMS Immunol. Med. Microbiol. 48:21-25.
26. Lancaster H, Ready D, Mullany P, Spratt D, Bedi R, Wilson M. 2003. Prevalence and identification of tetracycline-resistant oral bacteria in children not receiving antibiotic therapy. FEMS Microbiol. Lett. 228:99-104.
27. Shen Z, Pu XY, Zhang Q. 2011. Salicylate functions as an efflux pump inducer and promotes the emergence of fluoroquinolone-resistant Campylobacter jejuni mutants. Appl. Environ. Microbiol. 77:7128-7133.
28. Wang HH, Schaffner DW. 2011. Antibiotic resistance: how much do we know and where do we go from here?. Appl. Environ. Microbiol. 77:7093-7095.
29. Li X, Wang HH. 2010. Tetracycline resistance associated with commensal bacteria from representative ready-to-consume deli and restaurant foods. J. Food Prot. 73:1841-1848.
30. Osterblad M, Norrdahl K, Korpimaki E, Huovinen P. 2001. Antibiotic resistance. How wild are wild mammals?. Nature 409:37-38.
31. Ready D, Bedi R, Spratt DA, Mullany P, Wilson M. 2003. Prevalence, proportions, and identities of antibiotic-resistant bacteria in the oral microflora of healthy children. Microb. Drug Resist. 9:367-372.
32. Salyers AA, Gupta A, Wang Y. 2004. Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbiol. 12:412-416.
33. Chee-Sanford JC, Aminov RI, Krapac IJ, Garrigues-Jeanjean N, Mackie RI. 2001. Occurrence and diversity of tetracycline resistance genes in lagoons and groundwater underlying two swine production facilities. Appl. Environ. Microbiol. 67:1494-1502.
34. Lachmayr KL, Kerkhof LJ, Dirienzo AG, Cavanaugh CM, Ford TE. 2009. Quantifying nonspecific TEM beta-lactamase (blaTEM) genes in a wastewater stream. Appl. Environ. Microbiol. 75:203-211.
35. Smith MS, Yang RK, Knapp CW, Niu Y, Peak N, Hanfelt MM, Galland JC, Graham DW. 2004. Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR. Appl. Environ. Microbiol. 70:7372-7377.
36. Luo N, Pereira S, Sahin O, Lin J, Huang S, Michel L, Zhang Q. 2005. Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. Proc. Natl. Acad. Sci. U. S. A. 102:541-546.
37. Eickhoff T, Kislak J, Finland M. 1965. Sodium ampicillin: absorption and excretion of intramuscular and intravenous doses in normal young men. Am. J. Med. Sci. 249:163-171.
38. Fabre J, Milek E, Kalfopoulos P, Merier G. 1971. Kinetics of tetracyclines in human. II. Excretion, penetration into normal and inflamed tissues, behavior in a case of renal insufficiency and in hemodialysis. Schweiz. Med. Wochenschr. 101:625-633.