Mechanisms of herb-induced nephrotoxicity

Current Medicinal Chemistry

Volumn 20, Issue 22, 2013, Pages 2812-2819

  Allard, T ^a   Wenner, T ^a   Greten, H J ^b   Efferth, T ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Heidelberg School of Chinese Medicine   (Germany)

Author keywords

Analgesic nephropathy; Apoptosis; Blood pressure; DNA adducts; Mitochondrial ATP synthesis; Nephrolithiasis; Pharmacognosy; Phytotherapy

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARISTOLOCHIA FANGCHI EXTRACT; ARISTOLOCHIC ACID; CARBOXYATRACTYLOSIDE; DITERPENOID; EPHEDRA SINICA EXTRACT; EPHEDRINE; GLYCYRRHIZA GLABRA EXTRACT; GUAIFENESIN; HARPAGOPHYTUM PROCUMBENS EXTRACT; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; OXALIC ACID; REACTIVE OXYGEN METABOLITE; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; UNCARIA TOMENTOSA EXTRACT;

APOPTOSIS; ARISTOLOCHIA; ARTICLE; AVERRHOA CARAMBOLA; CARCINOGENESIS; CONCENTRATION (PARAMETERS); CRANBERRY JUICE; DNA ADDUCT; EPHEDRA SINICA; GLOMERULUS FILTRATION; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY TUBULE ABSORPTION; MITOCHONDRION; NEPHROLITHIASIS; NEPHROTOXICITY; PAUSINYSTALIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STANDARDIZATION; UNCARIA TOMENTOSA; WILLOW;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; ARACHIDONIC ACID; BLOOD PRESSURE; DNA ADDUCTS; HUMANS; KIDNEY DISEASES; PLANTS, MEDICINAL;

EID: 84880289205     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867311320220006     Document Type: Article

References (78)

1. Bacchetta, J.; Dubourg, L.; Juillard, L.; Cochat, P. Non-druginduced nephrotoxicity. Pediatr. Nephrol., 2009, 24(12), 2291-2300.
2. Luyckx, V.A.; Naicker, S. Acute kidney injury associated with the use of traditional medicines. Nat. Clin. Pract. Nephrol., 2008, 4(12), 664-671.
3. Wojcikowski, K.; Johnson, D.W.; Gobe, G. Herbs or natural substances as complementary therapies for chronic kidney disease: Ideas for future studies. J. Lab. Clin. Med., 2006, 147(4), 160-166.
4. Jha, V.; Rathi, M. Natural medicines causing acute kidney injury. Semin. Nephrol. 2008, 28(4), 416-428.
5. Ueda, N.; Kaushal, G.P.; Shah, S.V. Apoptotic mechanisms in acute renal failure. Am. J. Med. 2000, 108(5), 403-415.
6. Servais, H.; Ortiz, A.; Devuyst, O.; Denamur, S.; Tulkens, P.M.; Mingeot-Leclercq, M.P. Renal cell apoptosis induced by nephrotoxic drugs: Cellular and molecular mechanisms and potential approaches to modulation. Apoptosis, 2008, 13(1), 11-32.
7. Fang, H.C.; Lee, P.T.; Lu, P.J.; Chen, C.L.; Chang, T.Y.; Hsu, C.Y.; Chung, H.M.; Chou, K.J. Mechanisms of star fruit-induced acute renal failure. Food Chem. Toxicol., 2008, 46(5), 1744-1752.
8. Koul, S.; Fu, S.; Koul, H. Oxalate exposure promotes reinitiation of the DNA synthesis and apoptosis of HK-2 cells, a line of human renal epithelial cells. Ann. N. Y. Acad. Sci., 2003, 1010, 292-295.
9. Miller, C.; Kennington, L.; Cooney, R.; Kohjimoto, Y.; Cao, L.C.; Honeyman, T.; Pullman, J.; Jonassen, J.; Scheid, C. Oxalate toxicity in renal epithelial cells: Characteristics of apoptosis and necrosis. Toxicol. Appl. Pharmacol., 2000, 162(2), 132-141.
10. Sarica, K.; Yagci, F.; Bakir, K.; Erbagci, A.; Erturhan, S.; Uçak, R. Renal tubular injury induced by hyperoxaluria: Evaluation of apoptotic changes. Urol. Res., 2001, 29(1), 34-37.
11. Jonassen, J.A.; Kohjimoto, Y.; Scheid, C.R.; Schmidt, M. Oxalate toxicity in renal cells. Urol. Res., 2005, 33(5), 329-339.
12. Scheid, C.; Koul, H.; Hill, W.A.; Luber-Narod, J.; Jonassen, J.; Honeyman, T.; Kennington, L.; Kohli, R.; Hodapp, J.; Ayvazian, P.; Menon, M. Oxalate toxicity in LLC-PK1 cells, a line of renal epithelial cells. J. Urol., 1996, 155(3), 1112-1116.
13. Cao, L.C.; Jonassen, J.; Honeyman, T.W.; Scheid, C. Oxalateinduced redistribution of phosphatidylserine in renal epithelial cells: Implications for kidney stone disease. Am. J. Nephrol., 2001, 21(1), 69-77.
14. Jonassen, J.A., Cao, L.C.; Honeyman, T.; Scheid, C.R. Intracellular events in the initiation of calcium oxalate stones. Nephron. Exp. Nephrol., 2004, 98(2), e61-e64.
15. Yang, F.; Zhuo, L.; Ananda, S. Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats. J. Huazhong Univ. Sci. Technolog. Med. Sci., 2011, 31(3), 335-341.
16. Curhan, G.C. Epidemiologic evidence for the role of oxalate in idiopathic nephrolithiasis. J. Endourol. 1999, 13(9), 629-631.
17. Pickens, C.L.; Milliron, A.R.; Fussner, A.L.; Dversdall, B.C.; Langenstroer, P.; Ferguson, S.; Fu, X.; Schmitz, F.J.; Poole, E.C. Abuse of guaifenesin-containing medications generates an excess of a carboxylate salt of beta-(2-methoxyphenoxy)-lactic acid, a guaifenesin metabolite, and results in urolithiasis. Urology, 1999, 54(1), 23-27.
18. Touhami, M.; Laroubi, A.; Elhabazi, K.; Loubna, F.; Zrara, I.; Eljahiri, Y.; Oussama, A.; Grases, F.; Chait, A. Lemon juice has protective activity in a rat urolithiasis model. BMC Urol., 2007, 7, 18.
19. Vahlensieck, E.W.; Bach, D.; Hesse, A.; Strenge, A. Epidemiology, pathogenesis and diagnosis of calcium oxalate urolithiasis. Int. Urol. Nephrol. 1982, 14(4), 333-347.
20. Taylor, E.N.; Curhan, G.C. Oxalate intake and the risk for nephrolithiasis. J. Am. Soc. Nephrol., 2007, 18(7), 2198-2204.
21. Meschi, T.; Maggiore, U.; Fiaccadori, E.; Schianchi, T.; Bosi, S.; Adorni, G.; Ridolo, E.; Guerra, A.; Allegri, F.; Novarini, A.; Borghi, L. The effect of fruits and vegetables on urinary stone risk factors. Kidney Int., 2004, 66(6), 2402-2410.
22. Atmani, F.; Khan, S.R. Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. BJU Int., 2000, 85(6), 621-625.
23. Atmani, F.; Slimani, Y.; Mimouni, M.; Hacht, B. Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats. BJU Int., 2003, 92(1), 137-140.
24. Gettman, M.T.; Ogan, K.; Brinkley, L.J.; Adams-Huet, B.; Pak, C.Y.; Pearle, M.S. Effect of cranberry juice consumption on urinary stone risk factors. J. Urol., 2005, 174(2), 590-594.
25. Terris, M.K.; Issa, M.M.; Tacker, J.R. Dietary supplementation with cranberry concentrate tablets may increase the risk of nephrolithiasis. Urology, 2001, 57(1), 26-29.
26. Light, I.; Gursel, E.; Zinnser, H.H. Urinary ionized calcium in urolithiasis. Effect of cranberry juice. Urology, 1973, 1(1), 67-70.
27. Kessler, T.; Jansen, B.; Hesse, A. Effect of blackcurrant-, cranberry-and plum juice consumption on risk factors associated with kidney stone formation. Eur. J. Clin. Nutr. 2002, 56(10), 1020-1023.
28. McHarg, T.; Rodgers, A.; Charlton, K. Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation. BJU Int., 2003, 92(7), 765-768.
29. Assimos, D.G.; Langenstroer, P.; Leinbach, R.F.; Mandel, N.S.; Stern, J.M.; Holmes, R.P. Guaifenesin-and ephedrine-induced stones. J. Endourol., 1999, 13(9), 665-667.
30. Bennett, S.; Hoffman, N.; Monga, M. Ephedrine-and guaifenesininduced nephrolithiasis. J. Altern. Complement. Med., 2004, 10(6), 967-969.
31. Blau, J.J. Ephedrine nephrolithiasis associated with chronic ephedrine abuse. J. Urol., 1998, 160(1), 825.
32. Whelan, C.; Schwartz, B.F. Bilateral guaifenesin ureteral calculi. Urology, 2004, 63(1), 175-176.
33. Hoffman, N.; McGee, S.M.; Hulbert, J.C. Resolution of ephedrine stones with dissolution therapy. Urology, 2003, 61(5), 1035.
34. Smith, C.L.; Gemar, S.K.; Lewis, M.J. Pseudoephedrine urolithiasis associated with acute renal failure. Nephrol. Dial. Transplant., 2004, 19(1), 263-264.
35. Nortier, J.L.; Vanherweghem, J.L. For patients taking herbal therapy-lessons from aristolochic acid nephropathy. Nephrol. Dial. Transplant., 2007, 22(6), 1512-1517.
36. Schmeiser, H.H.; Bieler, C.A.; Wiessler, M. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res., 1996, 56(9), 2025-2028.
37. Lord, G.M.; Cook, T.; Arlt, V.M. Urothelial malignant disease and Chinese herbal nephropathy. Lancet, 2001, 358(9292), 1515-1516.
38. Jha, V. Herbal medicines and chronic kidney disease. Nephrology, (Carlton) 2010, 15 Suppl 2, 10-17.
39. Petzinger, E.; Ziegler, K. Ochratoxin A from a toxicological perspective. J. Vet. Pharmacol. Ther., 2000, 23(2), 91-98.
40. Combest, W.; Newton, M.; Combest, A.; Kosier, J.H. Effects of herbal supplements on the kidney. Urol. Nurs., 2005, 25(5), 381-386, 403.
41. Stefanović;, V.; Polenaković, M. Fifty years of research in Balkan endemic nephropathy: Where are we now? Nephron. Clin. Pract., 2009, 112(2), c51-c56.
42. Grollman, A.P.; Shibutani, S.; Moriya, M.; Miller, F.; Wu, L.; Moll, U.; Suzuki, N.; Fernandes, A.; Rosenquist, T.; Medverec, Z.; Jakovina, K.; Brdar, B.; Slade, N.; Turesky, R.J.; Goodenough, A.K.; Rieger, R.; Vukelić, M.; Jelaković, B. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. USA, 2007, 104(29), 12129-12134.
43. Popat, A.; Shear, N.H.; Malkiewicz, I.; Stewart, M.J.; Steenkamp, V.; Thomson, S.; Neuman, M.G. The toxicity of Callilepis laure ola, a South African traditional herbal medicine. Clin. Biochem., 2001, 34(3), 229-236.
44. Steenkamp, V.; Stewart, M.J.; Zuckerman, M. Detection of poisoning by Impila (Callilepis laureola) in a mother and child. Hum. Exp. Toxicol., 1999, 18(10), 594-597.
45. Seedat, Y.K.; Hitchcock, P.J. Acute renal failure from Callilepsis laureola. S. Afr. Med. J., 1971, 45(30), 832-833.
46. Watson, A.R.; Coovadia, H.M.; Bhoola, K.D. The clinical syndrome of Impila (Callilepis laureola) poisoning in children. S. Afr. Med. J., 1979, 55(8), 290-292.
47. Obatomi, D.K.; Bach, P.H. Inhibition of mitochondrial respiration and oxygen uptake in isolated rat renal tubular fragments by atractyloside. Toxicol. Lett., 1996, 89(2), 155-161.
48. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochim. Biophys. Acta, 2008, 1778(10), 1978-2021.
49. Stewart, P.M.; Wallace, A.M.; Valentino, R.; Burt, D.; Shackleton, C.H.; Edwards, C.R. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1987, 2(8563), 821-824.
50. Vancompernolle, K.; Van Herreweghe, F.; Pynaert, G.; Van de Craen, M.; De Vos, K.; Totty, N.; Sterling, A.; Fiers, W.; Vandenabeele, P.; Grooten, J. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett. 1998, 438(3), 150-158.
51. Hilepo, J.N.; Bellucci, A.G.; Mossey, R.T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron., 1997, 77(3), 361.
52. Sandoval, M.; Charbonnet, R.M.; Okuhama, N.N.; Roberts, J.; Krenova, Z.; Trentacosti, A.M.; Miller, M.J. Cat's claw inhibits TNFalpha production and scavenges free radicals: Role in cytoprotection. Free Radic. Biol. Med., 2000, 29(1), 71-78.
53. Knowles, S.R.; Uetrecht, J.; Shear, N.H. Idiosyncratic drug reactions: The reactive metabolite syndromes. Lancet, 2000, 356(9241), 1587-1591.
54. Garella, S.; Matarese, R.A. Renal effects of prostaglandins and clinical adverse effects of nonsteroidal anti-inflammatory agents. Medicine (Baltimore), 1984, 63(3), 165-181.
55. Carmichael, J.; Shankel, S.W. Effects of nonsteroidal antiinflammatory drugs on prostaglandins and renal function. Am. J. Med., 1985, 78(6), 992-1000.
56. McDonald, A.; DuBose, T.D.; Molony, D.A.; Verani, R. Nephrotoxicity of non-steroidal anti-inflammatory drugs. Lancet, 1994, 344(8921), 515-518.
57. Knights, K.M.; Tsoutsikos, P.; Miners, J.O. Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicity. Expert Opin. Drug Metab. Toxicol., 2005, 1(3), 399-408.
58. Hauser, A.C.; Derfler, K.; Balcke, P. Progression of renal insufficiency in analgesic nephropathy: Impact of continuous drug abuse. J. Clin. Epidemiol., 1991, 44(1), 53-56.
59. Vlachojannis, J.; Magora, F.; Chrubasik, S. Willow Species and Aspirin: Different Mechanism of Actions. Phytother. Res., 2011, 25(7):1102-1104.
60. Segasothy, M.; Samad, S. Illicit herbal preparation containing phenylbutazone causing analgesic nephropathy. Nephron., 1991, 59(1), 166-167.
61. Orth, S.R.; Ritz, E.; Schrier, R.W. The renal risks of smoking. Kidney Int., 1997, 51(6), 1669-1677.
62. Klag, M.J.; Whelton, P.K.; Randall, B.L.; Neaton, J.D.; Brancati, F.L.; Ford, C.E.; Shulman, N.B.; Stamler, J. Blood pressure and end-stage renal disease in men. N. Engl. J. Med., 1996, 334(1), 13-18.
63. Colson, C.R.; De Broe, M.E. Kidney injury from alternative medicines. Adv. Chronic Kidney Dis., 2005, 12(3), 261-275.
64. Powell, T.; Hsu, F.F.; Turk, J.; Hruska, K. Ma-huang strikes again: Ephedrine nephrolithiasis. Am. J. Kidney Dis., 1998, 32(1), 153-159.
65. Myhre, M.J. Herbal remedies, nephropathies, and renal disease. Nephrol. Nurs. J., 2000, 27(5), 473-478; quiz 479-80.
66. Nowack, R. Herb-drug interactions in nephrology: Documented and theoretical. Clin. Nephrol., 2008, 69(5), 319-325.
67. Cooper, R.G. Effect of tobacco smoking on renal function. Indian J. Med. Res. 2006, 124(3), 261-268.
68. Halimi, J.M.; Philippon, C.; Mimran, A. Contrasting renal effects of nicotine in smokers and non-smokers. Nephrol. Dial. Transplant., 1998, 13(4), 940-944.
69. Gambaro, G.; Verlato, F.; Budakovic, A.; Casara, D.; Saladini, G.; Del Prete, D.; Bertaglia, G.; Masiero, M.; Checchetto, S.; Baggio, B. Renal impairment in chronic cigarette smokers. J. Am. Soc. Nephrol., 1998, 9(4), 562-567.
70. Isnard Bagnis, C.; Deray, G.; Baumelou, A.; Le Quintrec, M.; Vanherweghem, J.L. Herbs and the kidney. Am. J. Kidney Dis., 2004, 44(1), 1-11.
71. Funder, J.W.; Pearce, P.T.; Smith, R.; Smith, A.I. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science, 1988, 242(4878), 583-585.
72. Dan, H.; Peng, R.X.; Ao, Y.; Liu, Y.H. Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats. J. Biochem. Mol. Toxicol., 2008, 22, 422-428.
73. Li, X.; Wang, H. Chinese herbal medicine in the treatment of chronic kidney disease. Adv. Chronic Kidney Dis., 2005, 12(3), 276-281.
74. Lao, Y.M.; Jiang, J.G.; Yan, L. Application of metabonomic analytical techniques in the modernization and toxicology research of traditional Chinese medicine. Br. J. Pharmacol., 2009, 157(7), 1128-1141.
75. Romiti, N.; Tramonti, G.; Corti, A.; Chieli, E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine, 2009, 16(12), 1095-1100.
76. Kaszkin, M.; Beck, K.F.; Koch, E.; Erdelmeier, C.; Kusch, S.; Pfeilschifter, J.; Loew, D. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine, 2004, 11(7-8), 585-595.
77. Izumotani, T.; Ishimura, E.; Tsumura, K.; Goto, K.; Nishizawa, Y.; Morii, H. An adult case of Fanconi syndrome due to a mixture of Chinese crude drugs. Nephron, 1993, 65(1), 137-140.
78. Itoh, K.; Hara, T.; Shiraishi, T.; Taniguchi, K.; Morimoto, S.; Onishi, T. Effects of glycyrrhizin and glycyrrhetinic acid on (Na++ K+)-ATPase of renal basolateral membranes in vitro. Biochem. Int., 1989, 18(1), 81-89.