HPLC-ESI-MS/MS analysis of hemoglobin peptides in tryptic digests of dried-blood spot extracts detects HbS, HbC, HbD, HbE, HbO-Arab, and HbG-Philadelphia mutations

Clinica Chimica Acta

Volumn 424, Issue , 2013, Pages 191-200

  Haynes, Christopher A ^a   Guerra, Stephanie L ^b   Fontana, Jessalyn C ^c   DeJesús, Víctor R ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT SPRINGFIELD   (United States)

Author keywords

Dried blood spot; Hemoglobinopathies; HPLC ESI MS MS

Indexed keywords

ALANINE; CYSTEINE; CYTOSINE; DNA FRAGMENT; GLYCINE; HAPTOGLOBIN O; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN C; HEMOGLOBIN D; HEMOGLOBIN E; HEMOGLOBIN G; HEMOGLOBIN GAMMA CHAIN; HEMOGLOBIN PEPTIDE; HEMOGLOBIN S; METHIONINE; MUTANT PROTEIN; PEPTIDE; THREONINE; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARAB; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; DRIED BLOOD SPOT TESTING; ELECTROSPRAY; HEMOGLOBINOPATHY; HETEROZYGOSITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMOZYGOSITY; HUMAN; MUTATIONAL ANALYSIS; NEWBORN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; TANDEM MASS SPECTROMETRY; UNITED STATES;

CID; COLLISION-INDUCED DISSOCIATION; DBS; DRIED-BLOOD SPOT; ELECTROSPRAY IONIZATION; ESI; HB; HEMOGLOBIN; HEMOGLOBINOPATHIES; HPLC-ESI-MS/MS; IEF; ISOELECTRIC FOCUSING GEL; MALDI; MATRIX-ASSISTED LASER DESORPTION IONIZATION; SIM; SINGLE-ION MONITORING;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRIED BLOOD SPOT TESTING; HEMOGLOBIN C; HEMOGLOBIN E; HEMOGLOBIN, SICKLE; HEMOGLOBINS, ABNORMAL; HETEROZYGOTE; HUMANS; INFANT, NEWBORN; MUTATION; PEPTIDES; PROTEOLYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 84880284460     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2013.06.007     Document Type: Article

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