Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: Detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes

Analytical Chemistry

Volumn 75, Issue 9, 2003, Pages 1978-1982

  Rai, Dilip K ^a   Griffiths, William J ^b   Landin, Britta ^a   Wild, Barbara J ^c   Alvelius, Gunvor ^b   Green, Brian N ^d  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

^d MICROMASS UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; ELECTROPHORESIS; HEMOGLOBIN; ION EXCHANGE; IONIZATION; POSITIVE IONS; STATISTICAL METHODS;

ELECTROSPRAY IONIZATION;

MASS SPECTROMETRY;

HEMOGLOBIN VARIANT;

ACCURACY; ALPHA CHAIN; ARTICLE; BETA CHAIN; CALIBRATION; CATION EXCHANGE; CONTROLLED STUDY; ELECTROPHORESIS; HEMOGLOBIN ANALYSIS; HETEROZYGOTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS; MASS SPECTROMETRY; SCREENING TEST;

CALIBRATION; ELECTROPHORESIS; HEMOGLOBINS, ABNORMAL; HETEROZYGOTE; HUMANS; MUTATION; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0037509972     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac026228h     Document Type: Article

References (16)

1. Shackleton, C. H. L; Witkowska, H. E. In Mass Spectrometry: Clinical and Biomedical Applications; Desiderio, D. M., Ed.; Plenum: New York, 1994; Vol. 2, pp 135-199.
2. Wild, B. J.; Green, B. N.; Cooper, E. K.; Lalloz, M. R. A.; Erten, S.; Stephens, A. D.; Layton, D. M. Blood Cells Mol. Dis. 2001, 27, 691-704.
3. Shackleton, C. H. L.; Falick, A. M.; Green, B. N.; Witkowska, H. E. J. Chromatogr. 1991, 562, 175-190.
4. Tang, Q.; Harrata, A. K.; Lee, C. S. Anal. Chem. 1996, 68, 2482-2487.
5. Rai, D. K.; Alvelius G.; Landin, B.; Griffiths, W. J. Rapid Commun. Mass Spectrom. 2000, 14, 1184-1194.
6. Rai, D. K.; Griffiths, W. J.; Alvelius, G.; Landin, B. Clin. Chem. 2001, 47, 1308-1311.
7. Yang, L.; Lee, C. S.; Hofstadler, S. A.; Pasa-Tolic, L.; Smith, R. D. Anal. Chem. 1998, 70, 3235-3241.
8. Beynon, J. H. Nature 1954, 174, 135.
9. Roboz, J.; Holland, J. F.; McDowall, M. A.; Hillmer, M. J. Rapid Commun. Mass Spectrom. 1988, 2, 64-66.
10. Wada, Y.; Tamura, J.; Musselman, B. D.; Kassel, D. B.; Sakurai, T.; Matsuo, T. Rapid Commun. Mass Spectrom. 1992, 6, 9-13.
11. Feng, R.; Konishi, Y.; Bell, A. W. J. Am. Mass Spectrom. 1991, 2, 387-401.
12. Cody, R. B.; Tamura, J.; Musselman, B. D. Anal. Chem. 1992, 64, 1561-1570.
13. Tyler, A. N.; Clayton, E.; Green, B. N. Anal. Chem. 1996, 68, 3561-3569.
14. Rai, D. K.; Landin, B.; Alvelius, G.; Griffiths, W. J. Proc. 50th ASMS Conf. Mass Spectrometry and Allied Topics; Orlando, FL, 2002.
15. Globin gene server. http://globin.cse.psu.edu.
16. IUPAC commission on atomic weights and isotopic abundances. J. Phys. Chem. 1993, 22, 1571-1584.