Characterization of unstable hemoglobin A1c complexes by dynamic capillary isoelectric focusing

Analytical Biochemistry

Volumn 424, Issue 2, 2012, Pages 149-155

  Hempe, James M ^a,b   McGehee, Amanda M ^a   Hsia, Daniel ^b   Chalew, Stuart A ^a,b  

^a CHILDREN S HOSPITAL   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Boronate affinity chromatography; Capillary electrophoresis; Diabetes; Glycated hemoglobin; Hemoglobin A1c; Hemoglobin glycation index

Indexed keywords

AFFINITY CHROMATOGRAPHY; BLOOD; CAPILLARY ELECTROPHORESIS; DISSOCIATION; FOCUSING; GLUCOSE; GLYCOSYLATION; MEDICAL PROBLEMS;

AFFINITY COLUMN; AMADORI PRODUCT; BORONATE; CAPILLARY ISOELECTRIC FOCUSING; GLYCATED HEMOGLOBINS; GLYCATION; PHOSPHATE-BUFFERED SALINES; SCHIFF BASE COMPLEXES;

HEMOGLOBIN;

GLUCOSE; HEMOGLOBIN A1C; SCHIFF BASE;

AFFINITY CHROMATOGRAPHY; ARTICLE; ERYTHROCYTE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN CELL; ISOELECTRIC FOCUSING; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION;

EID: 84859093147     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.02.011     Document Type: Article

References (53)

1. H.F. Bunn, R. Shapiro, M. McManus, L. Garrick, M.J. McDonald, P.M. Gallop, and K.H. Gabbay Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation J. Biol. Chem. 254 1979 3892 3898 (Pubitemid 9178801)
2. R. Shapiro, M. McManus, L. Garrick, M.J. McDonald, and H.F. Bunn Nonenzymatic glycosylation of human hemoglobin at multiple sites Metabolism 28 1979 427 430 (Pubitemid 9177033)
3. H.F. Bunn, and B.G. Forget Hemoglobin: molecular, Genetic, and Clinical Aspects 1986 W. B. Saunders Philadelphia
4. R. Fluckiger, and P.M. Gallop Measurement of nonenzymatic protein glycosylation Methods Enzymol. 106 1984 77 87 (Pubitemid 14079121)
5. A.S. Acharya, and L.G. Sussman The reversibility of the ketoamine linkages of aldoses with proteins J. Biol. Chem. 259 1984 4372 4378 (Pubitemid 14127802)
6. D.E. Goldstein, R.R. Little, R.A. Lorenz, J.I. Malone, D. Nathan, and C.M. Peterson Tests of glycemia in diabetes Diabetes Care 18 1995 896 909
7. S.A. Chalew, R.J. McCarter, J. Ory-Ascani, and J.M. Hempe Labile hemoglobin A1c is inversely correlated with the hemoglobin glycation index in children with type 1 diabetes Diabetes Care 33 2010 273 274
8. J.M. Hempe, and R.D. Craver Quantification of hemoglobin variants by capillary isoelectric focusing Clin. Chem. 40 1994 2288 2295
9. J.M. Hempe, R. Gomez, R.J. McCarter, and S.A. Chalew High and low hemoglobin glycation phenotypes in type 1 diabetes: a challenge for interpretation of glycemic control J. Diab. Comp. 16 2002 313 320
10. R.J. McCarter, J.M. Hempe, R. Gomez, and S.A. Chalew Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes Diabetes Care 27 2004 1259 1264 (Pubitemid 38679967)
11. A.A. Soros, S.A. Chalew, R.J. McCarter, R. Shepard, and J.M. Hempe Hemoglobin glycation index: a robust measure of hemoglobin A1c bias in pediatric type 1 diabetes patients Pediatr. Diabetes 11 2010 455 461
12. D.M. Wilson, C. Kollman, D. Xing, R. Fiallo-Scharer, S. Weinzimer, M. Steffes, T. Wysocki, R. Beck, K. Ruedy, and W. Tamborlane Relationship of A1c to glucose concentrations in children with type 1 diabetes: assessments by high-frequency glucose determinations by sensors Diabetes Care 31 2008 381 385
13. R.E. Mullins, and G.E. Austin Sensitivity of isoelectric focusing, ion exchange, and affinity chromatography to labile glycated hemoglobin Clin. Chem. 32 1986 1460 1463 (Pubitemid 17027759)
14. M.H. Stickland, C.M. Perkins, and J.K. Wales The measurement of haemoglobin A1c by isoelectric focussing in diabetic patients Diabetologia 22 1982 315 317 (Pubitemid 12154514)
15. H.B. Mortensen Glycated hemoglobin: reaction and biokinetic studies - Clinical application of hemoglobin A1c in the assessment of metabolic control in children with diabetes mellitus Dan. Med. Bull. 32 1985 309 328 (Pubitemid 16219134)
16. A. Terreni, R. Paleari, A. Caldini, A. Ognibene, A. Mosca, and G. Messeri Evaluation of the analytic performances of the new HPLC system HLC-723 G7 for the measurement of hemoglobin A1c Clin. Biochem. 36 2003 607 610 (Pubitemid 37434026)
17. I. Gibb, A. Parnham, M. Fonfrede, and F. Lecock Multicenter evaluation of Tosoh glycohemoglobin analyzer Clin. Chem. 45 1999 1833 1841 (Pubitemid 29477343)
18. S. Mack, I. Cruzado-Park, J. Chapman, C. Ratnayake, and G. Vigh A systematic study in CIEF: defining and optimizing experimental parameters critical to method reproducibility and robustness Electrophoresis 30 2009 4049 4058
19. K. Shimura Recent advances in IEF in capillary tubes and microchips Electrophoresis 30 2009 11 28
20. D. Koval, V. Kasicka, and H. Cottet Analysis of glycated hemoglobin A1c by capillary electrophoresis and capillary isoelectric focusing Anal. Biochem. 413 2011 8 15
21. J.M. Hempe Protein analysis by capillary electrophoresis J.P. Landers, Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques 2008 CRC Press Boca Raton, FL 75 107
22. J. Wang, S. Zhou, W. Huang, Y. Liu, C. Cheng, X. Lu, and J. Cheng CE-based analysis of hemoglobin and its applications in clinical analysis Electrophoresis 27 2006 3108 3124 (Pubitemid 44269528)
23. Q. Tang, A.K. Harrata, and C.S. Lee High-resolution capillary isoelectric focusing-electrospray ionization mass spectrometry for hemoglobin variants analysis Anal. Chem. 68 1996 2482 2487
24. J.M. Hempe, A.M. McGehee, and A.V. Stoyanov Analysis of murine S-glutathionyl hemoglobins and beta globin haplotype by dynamic capillary isoelectric focusing J. Chromatogr. B 877 2009 3462 3466
25. G.G. Thom, C. Kallanagowdar, S.S. Somjee, M.C. Velez, L.C. Yu, and J.M. Hempe Characterization of S-glutathionyl hemoglobin in homozygous sickle cell disease J Pediatr. Hematol. Oncol. 31 2009 895 900
26. J.M. Hempe, A. Vargas, and R.D. Craver Clinical analysis of structural hemoglobin variants and HbA1c by capillary isoelectric focusing J.R. Petersen, A.A. Mohammad, Clinical and Forensic Applications of Capillary Electrophoresis 2001 Humana Totowa, NJ 145 163
27. B.S. Welinder, and P.A. Svendsen Heterogeneity of the haemoglobin-A1c band in isoelectric focussing Diabetologia 19 1980 465 467 (Pubitemid 11226500)
28. H.B. Mortensen, and C. Christophersen Glucosylation of human haemoglobin A in red blood cells studied in vitro: kinetics of the formation and dissociation of haemoglobin A1c Clin. Chim. Acta 134 1983 317 326 (Pubitemid 13017371)
29. M.D. Clegg, and W.A. Schroeder A chromatographic study of the minor components of normal adult human hemoglobin including a comparison of hemoglobin from normal and phenylketonuric individuals J. Am. Chem. Soc. 81 1959 6065 6069
30. J.W. Drysdale, P. Righetti, and H.F. Bunn The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel Biochim. Biophys. Acta 229 1971 42 50
31. K.M. Spicer, R.C. Allen, and M.G. Buse A simplified assay of hemoglobin AIc in diabetic patients by use of isoelectric focusing and quantitative microdensitometry Diabetes 27 1978 384 388 (Pubitemid 8324705)
32. W.R. Holmquist, and W.A. Schroeder A new N-terminal blocking group involving a Schiff base in hemoglobin AIc Biochemistry 5 1966 2489 2503
33. M.H. Garner, R.A. Bogardt Jr., and F.R. Gurd Determination of the pK values for the α-amino groups of human hemoglobin J. Biol. Chem. 250 1975 4398 4404
34. P.J. Higgins, and H.F. Bunn Kinetic analysis of the nonenzymatic glycosylation of hemoglobin J. Biol. Chem. 256 1981 5204 5208 (Pubitemid 11057898)
35. E.C. Abraham, R.E. Perry, and M. Stallings Application of affinity chromatography for separation and quantitation of glycosylated hemoglobins J. Lab. Clin. Med. 102 1983 187 197 (Pubitemid 13029257)
36. W.G. John Effect of Schiff base (labile fraction) on the measurement of glycated hemoglobin by affinity chromatography Clin. Chem. 30 1984 1111 1112
37. K. Sullivan, and P. Raskin Evaluation of a new automated affinity-chromatographic method for the measurement of glycated hemoglobin Diabetes Res. Clin. Pract. 13 1991 103 106
38. F.A. Middle, A. Bannister, A.J. Bellingham, and D.G. Dean Separation of glycosylated haemoglobins using immoblized phenylboronic acid Biochem. J. 209 1983 771 779
39. R. Fluckiger, T. Woodtli, and W. Berger Quantitation of glycosylated hemoglobin by boronate affinity chromatography Diabetes 33 1984 73 76 (Pubitemid 14187206)
40. E. Bisse, P. Huaman-Guillen, and H. Wieland Chromatographic evaluation of minor hemoglobins: clinical significance of hemoglobin A1d, comparison with hemoglobin A1c, and possible interferences Clin. Chem. 41 1995 658 663
41. F.Q. Nuttall Comparison of percent total GHb with percent HbA1c in people with and without known diabetes Diabetes Care 21 1998 1475 1480
42. D.N. Haney, and H.F. Bunn Glycosylation of hemoglobin in vitro: affinity labeling of hemoglobin by glucose-6-phosphate Proc. Natl. Acad. Sci. USA 73 1976 3534 3538
43. X. Zhang, K.F. Medzihradszky, J. Cunningham, P.D. Lee, C.L. Rognerud, C.N. Ou, P. Harmatz, and H.E. Witkowska Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation J. Chromatogr. B 759 2001 1 15 (Pubitemid 32595431)
44. K.B. Rubinow, and I.B. Hirsch Reexamining metrics for glucose control JAMA 305 2011 1132 1133
45. H. Snieder, P.A. Sawtell, L. Ross, J. Walker, T.D. Spector, and R.D. Leslie HbA1c levels are genetically determined even in type 1 diabetes: evidence from healthy and diabetic twins Diabetes 50 2001 2858 2863 (Pubitemid 33733139)
46. R.M. Cohen, Y.R. Holmes, T.C. Chenier, and C.H. Joiner Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy Diabetes Care 26 2003 163 167 (Pubitemid 36929010)
47. W.H. Herman, and R.M. Cohen Hemoglobin A1c: teaching a new dog old tricks Ann. Intern. Med. 152 2010 815 817
48. J.L. Kamps, J.M. Hempe, and S.A. Chalew Racial disparity in hemoglobin A1c independent of mean blood glucose in children with type 1 diabetes Diabetes Care 33 2010 1025 1027
49. M.B. Davidson, and D.L. Schriger Effect of age and race/ethnicity on HbA1c levels in people without known diabetes mellitus: implications for the diagnosis of diabetes Diabetes Res. Clin. Pract. 87 2010 415 421
50. S. Dagogo-Jack Pitfalls in the use of HbA1c as a diagnostic test: the ethnic conundrum Nat. Rev. Endocrinol. 6 2010 589 593
51. G. Lippi, and G. Targher A laboratory standpoint on the role of hemoglobin A1c for the diagnosis of diabetes in childhood: more doubts than certainties? Pediatr. Diabetes 12 2011 183 186
52. R.M. Cohen, S. Haggerty, and W.H. Herman HbA1c for the diagnosis of diabetes and prediabetes: is it time for a mid-course correction? J. Clin. Endocrinol. Metab. 95 2010 5203 5206
53. R.M. Cohen A1C: does one size fit all? Diabetes Care 30 2007 2756 2758 (Pubitemid 47547834)