ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer

Oncogene

Volumn 32, Issue 28, 2013, Pages 3319-3328

  Du, W ^a,b   Wang, S ^a   Zhou, Q ^a   Li, X ^a   Chu, J ^c   Chang, Z ^d   Tao, Q ^a   Ng, E K O ^a   Fang, J ^b   Sung, J J Y ^a   Yu, J ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^d Tsinghua University   (China)

Author keywords

ADAMTS9; AKT mTOR pathway; Gastric cancer; Prognosis; Tumor suppressor

Indexed keywords

DISINTEGRIN LIKE AND METALLOPROTEASE WITH THROMBOSPONDIN TYPE 1 MOTIF; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PROTEIN KINASE B; S6 KINASE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DEMETHYLATION; DISEASE ASSOCIATION; DOWN REGULATION; EPIGENETICS; GENE INACTIVATION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STABLE EXPRESSION; STOMACH CANCER;

ADAM PROTEINS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; FEMALE; HUMANS; MALE; MICE; NEOVASCULARIZATION, PATHOLOGIC; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA; MUS MUSCULUS;

EID: 84880278967     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.359     Document Type: Article

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