Atypical β-adrenoceptors, different from β 3-adrenoceptors and probably from the low-affinity state of β 1-adrenoceptors, relax the rat isolated mesenteric artery

British Journal of Pharmacology

Volumn 140, Issue 1, 2003, Pages 3-12

  Kozłowska, Hanna ^a   Szymska, Urszula ^a   Schlicker, Eberhard ^b   Malinowska, Barbara ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

3 adrenoceptors; Atypical adrenoceptors; Bupranolol; CGP 1217.7; CGP 20712; CL 316243; Cyanopindolol; Rat mesenteric artery; SR 59230A; ZD 2079

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [(2 HYDROXY 2 PHENYLETHYL)AMINO]ETHOXY]PHENYLACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRANOLOL; CYANOPINDOLOL; FENOTEROL; ISOPRENALINE; PARTIAL AGONIST; PHENYLEPHRINE; PROPRANOLOL; SEROTONIN;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ISOLATED ARTERY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR AFFINITY;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESENTERIC ARTERIES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-3; VASODILATION;

EID: 4244216820     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705421     Document Type: Article

References (33)

1. 3 receptors. A promising antidiabetic and antiobesity agent. J. Med. Chem., 35, 3081-3084.
2. 1-adrenoceptors mediating relaxation in rat isolated aorta. Br. J. Pharmacol., 138, 99-106.
3. 2- and atypical β-adrenoceptor-mediated relaxation in rat isolated aorta. Br. J. Pharmacol., 129, 637-644.
4. BRAWLEY, L., SHAW, A.M. & MACDONALD, A. (2000b). Role of endothelium/nitric oxide in atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta. Eur. J. Pharmacol., 398, 285-296.
5. BRODDE, O.-E. & MICHEL, M.C. (1999). Adrenergic and muscarinic receptors in the human heart. Pharmacol. Rev., 51, 651-690.
6. 3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 359, 310-321.
7. 3 receptors and rat atrial receptors mediating tachycardia. Br. J. Pharmacol., 126, 1018-1024.
8. 2-adrenoceptor blocking activities of (±)-, (+) and (-)-pindolol on the rat isolated aorta. J. Pharm. Pharmacol., 42, 444-446.
9. 3-adrenoceptor antagonist SR 59230A. Eur. J. Pharmacol., 348, 223-228.
10. 4-adrenoceptor. Br. J. Pharmacol., 122, 1244-1250.
11. 3-adrenoceptor agonists. J. Pharmacol. Exp. Ther., 290, 687-693.
12. GUIMARÃES, S. & MOURA, D. (2001). Vascular adrenoceptors: an update. Pharmacol. Rev., 53, 319-356.
13. 4-adrenoceptor pharmacology. Naunyn-Schmiedeberg's Arch. Pharmacol., 363, 87-93.
14. 3-adrenoceptor in the rat. Br. J. Pharmacol., 118, 2085-2098.
15. KAUMANN, A.J. & MOLENAAR, P. (1997). Modulation of human cardiac function through 4 beta-adrenoceptor populations. Naunyn-Schmiedeberg's Arch. Pharmacol., 355, 667-681.
16. MACDONALD, A., MCLEAN, M., MACAULAY, L. & SHAW, A.M. (1999). Effects of propranolol and L-NAME on beta-adrenoceptor-mediated relaxation in rat carotid artery. J. Anton. Pharmacol., 19, 145-149.
17. 3-adrenoceptors. Br. J. Pharmacol., 117, 943-949.
18. 3-adrenoceptors in the pithed rat. Br. J. Pharmacol., 122, 1307-1314.
19. ORIOWO, M.A. (1994). Atypical β-adrenoceptors in the rat isolated common carotid artery. Br. J. Pharmacol., 113, 699-702.
20. ORIOWO, M.A. (1995). Different atypical β-adrenoceptors mediate isoprenaline-induced relaxation in vascular and non-vascular smooth muscles. Life Sci., 56, PL 269-PL 275.
21. RAUTUREAU, Y., TOUMANIANTZ, G., SERPILLON, S., JOURDON, P., TROCHU, J.N. & GAUTHIER, C. (2002). Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway. Br. J. Pharmacol., 137, 153-161.
22. 3-adrenoceptors in rat ileum. Br. J. Pharmacol., 127, 949-961.
23. 2-adrenergic receptors. J. Biol. Chem., 274, 16701-16708.
24. SHAFIEI, M. & MAHMOUDIAN, M. (1999). Atypical β-adrenoceptors of rat thoracic aorta. Gen. Pharmacol., 32, 557-562.
25. SHAFIEI, M., OMRANI, G. & MAHMOUDIAN, M. (2000). Coexistence of at least three distinct beta-adrenoceptors in human internal mammary artery. Acta Physiol. Hung., 87, 275-286.
26. 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs. J. Pharmacol. Exp. Ther., 278, 1435-1443.
27. SOOCH, S. & MARSHALL, I. (1997). Atypical β-adrenoceptors in the rat vasculature. Ann. N.Y. Acad. Sci. U.S.A., 812, 211-212.
28. TAGAYA, E., TAMAOKI, J., TAKEMURA, H., ISONO, K. & NAGAI, A. (1999). Atypical adrenoceptor-mediated relaxation of canine pulmonary artery through a cyclic adenosine monophosphate-dependent pathway. Lungs, 177, 321-332.
29. TAKAHASHI, H., YOSHIDA, T., NISMURA, N., NAKANISHI, T., KONDO, M. & YOSHIMURA, M. (1992). Beta3-adrenergic agonist, BRL-26830A, and alpha/beta blocker, arotinolol, markedly increase regional blood flow in the brown tissue in anaesthetized rats. Jpn. Circ. J., 56, 936-942.
30. TORRENS, C., BRAWLEY, L., ITOH, S., POSTON, L. & HANSON, M.A. (2002). Atypical β-adrenoceptor-mediated vasodilatation in rat isolated small mesenteric arteries. Br. J. Pharmacol., 135, 59.
31. TROCHU, J.-N., LEBLAIS, V., RAUTUREAU, Y., BÉVÉRELLI, F., LE MAREC, H., BERDEAUX, A. & GAUTHIER, C. (1999). Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta. Br. J. Pharmacol., 128, 69-76.
32. 2+ channels in rat portal vein myocytes. Br. J. Pharmacol., 129, 1497-1505.
33. 3-adrenergic receptors in brown adipocytes. Can. J. Physiol. Pharmacol., 76, 428-433.