Does resveratrol improve insulin signaling in chronically ischemic myocardium?

Journal of Surgical Research

Volumn 183, Issue 2, 2013, Pages 531-536

  Sabe, Ashraf A ^a   Elmadhun, Nassrene Y ^a   Robich, Michael P ^a   Dalal, Rahul S ^a   Sellke, Frank W ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Chronic myocardial ischemia; Diabetes; Glucose metabolism; Insulin signaling; Metabolic syndrome; Resveratrol

Indexed keywords

GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHORYLATED AMP ACTIVATED PROTEIN KINASE ALPHA; PROTEIN KINASE; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL DIET; CHRONIC DISEASE; CHRONIC MYOCARDIAL ISCHEMIA; HEART MUSCLE ISCHEMIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; METABOLIC SYNDROME X; NONHUMAN; PRIORITY JOURNAL; SWINE; WESTERN BLOTTING;

CHRONIC MYOCARDIAL ISCHEMIA; DIABETES; GLUCOSE METABOLISM; INSULIN SIGNALING; METABOLIC SYNDROME; RESVERATROL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; GLUCOSE; INSULIN; MALE; METABOLIC SYNDROME X; MYOCARDIAL ISCHEMIA; MYOCARDIUM; SIGNAL TRANSDUCTION; STILBENES; SWINE;

EID: 84880270748     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.03.004     Document Type: Article

References (21)

1. G.K. Hansson Inflammation, atherosclerosis, and coronary artery disease N Engl J Med 352 2005 1685
2. A. Behn, and E. Ur The obesity epidemic and its cardiovascular consequences Curr Opin Cardiol 21 2006 353
3. R.A. DeFronzo, A.H. Stonehouse, J. Han, and M.E. Wintle Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials Diabet Med 27 2010 309
4. K.E. Bornfeldt, and I. Tabas Insulin resistance, hyperglycemia, and atherosclerosis Cell Metab 14 2011 575
5. L.M. Chu, A.D. Lassaletta, M.P. Robich, and F.W. Sellke Resveratrol in the prevention and treatment of coronary artery disease Curr Atheroscler Rep 13 2011 439
6. M. de Lorgeril, P. Salen, A. Guiraud, F. Boucher, and J. de Leiris Resveratrol and non-ethanolic components of wine in experimental cardiology Nutr Metab Cardiovasc Dis 13 2003 100
7. M.P. Robich, R.M. Osipov, and L.M. Chu Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia Eur J Pharmacol 664 2011 45
8. T. Szkudelski, and K. Szkudelska Anti-diabetic effects of resveratrol Ann N Y Acad Sci 1215 2011 34
9. W. Kang, H.J. Hong, and J. Guan Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents Metabolism 61 2012 424
10. P. Brasnyo, G.A. Molnar, and M. Mohas Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients Br J Nutr 106 2011 383
11. T.A. Burgess, M.P. Robich, L.M. Chu, C. Bianchi, and F.W. Sellke Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle Arch Surg 146 2011 556
12. M.P. Robich, L.M. Chu, and T.A. Burgess Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome J Am Coll Surg 215 2012 681
13. J. Lee, Y. Xu, and L. Lu Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity Am J Physiol Heart Circ Physiol 298 2010 H310
14. Y. Fischer, J. Thomas, and L. Sevilla Insulin-induced recruitment of glucose transporter 4 (GLUT4) and GLUT1 in isolated rat cardiac myocytes. Evidence of the existence of different intracellular GLUT4 vesicle populations J Biol Chem 272 1997 7085
15. Y. Fischer, J. Thomas, P. Rosen, and H. Kammermeier Action of metformin on glucose transport and glucose transporter GLUT1 and GLUT4 in heart muscle cells from healthy and diabetic rats Endocrinology 136 1995 412
16. L.M. Chu, R.M. Osipov, and M.P. Robich Is hyperglycemia bad for the heart during acute ischemia? J Thorac Cardiovasc Surg 140 2010 1345
17. R.R. Russell 3rd, J. Li, and D.L. Coven AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury J Clin Invest 114 2004 495
18. L. Bertrand, S. Horman, C. Beauloye, and J.L. Vanoverschelde Insulin signalling in the heart Cardiovasc Res 79 2008 238
19. S. Gray, and J.K. Kim New insights into insulin resistance in the diabetic heart Trends Endocrinol Metab 22 2011 394
20. W. Abbud, S. Habinowski, and J.Z. Zhang Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport Arch Biochem Biophys 380 2000 347
21. Summary of Scientific Working Group Discussion - December 8th 2012 2nd International Scientific Conference on Resveratrol and Health 2012 University of Leicester Leicester, United Kingdom