Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 386, Issue 8, 2013, Pages 705-710

  Prabhakar, Orsu ^a  

^a Srinivasa Rao College of Pharmacy   (India)

Author keywords

Diabetes; Inflammation; Ischemia reperfusion injury; Oxidative stress

Indexed keywords

CATALASE; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; RESVERATROL; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYTOKINE; NEUROPROTECTIVE AGENT; PEROXIDASE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; COMMON CAROTID ARTERY; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; ANIMAL; BRAIN; CEREBRAL INFARCTION; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BRAIN; CATALASE; CEREBRAL INFARCTION; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; STILBENES; SUPEROXIDE DISMUTASE;

EID: 84880265121     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0871-2     Document Type: Article

References (35)

1. Aebi H (1974) Catalase. In: Bergmer HU (ed) Methods in enzymatic analysis, vol 2. Academic, New York, pp 673-684
2. Aggarwal BB, Bhardwai A, Aggarwal RS et al (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24:2783-40
3. Andrabi SA, Spina MG, Lorenz P et al (2004) Oxyresveratrol (trans-2, 3′, 4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res 1017:98-7
4. Canbaz S, Duran E (2003) Ischaemia-reperfusion studies and diabetes mellitus. Br J Anaesth 91:158-159
5. Dawn B (2007) Resveratrol: ready for prime time? J Mol Cell Cardiol 42:484-486
6. de la Lastra CA, Villegas I (2007) Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem Soc Trans 35:1156-1160
7. Del Zoppo GJ (1997) Microvascular responses to cerebral ischemia/inflammation. Ann NY Acad Sci 823:132-147
8. Della-Morte D, Dave KR, DeFazio RA et al (2009) Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 159:993-1002
9. Di Carlo A (2009) Human and economic burden of stroke. Age Ageing 38:4-5
10. Gouwy M, Struyf S, Proost P, Van Damme J (2005) Synergy in cytokine and chemokine networks amplifies the inflammatory response. Cytokine Growth Factor Rev 16:561-580
11. Iwasaki Y, Ito S, Suzuki M, Nagahori T, Yamamato T, Konno H (1989) Forebrain ischemia induced by temporary bilateral common carotid occlusion in normotensive rats. J Neurol Sci 90:155-5
12. Juhasz B, Varga B, Gesztelyi R et al (2010) Resveratrol: a multifunctional cytoprotective molecule. Curr Pharm Biotechnol 11:810-818
13. Kakkar P, Das B, Viswanathan PN (1984) A modified spectrophotometric assay of superoxide dismutase. Ind J Bio Chem Biophys 21:130-132
14. Kaste M (1997) Current therapeutic options for brain ischemia. Neurology 49:s56-s59
15. Khan M, Siphon B, Jatana M, Giri S et al (2004) Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res 76:519-7
16. Kim HK (1997) Experimental models of cerebral ischemia. Acta Anaesthesiol Scand Suppl 111:91-92
17. Lakhan SE, Kirchgessner A, Hofer M (2009) Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7:97
18. Liu N, Chen R, Du H, Wang J, Zhang Y, Wen J (2009) Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells. Cell Mol Immunol 6:207-213
19. Markus MA, Morris BJ (2008) Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging 2:331-339
20. Mukherjee PK, Ahamed KF, Kumar V, Mukherjee K, Houghton PJ (2007) Protective effect of biflavones from Araucaria bidwillii Hook in rat cerebral ischemia/reperfusion induced oxidative stress. Behav Brain Res 178:221-228
21. Mullane KM, Bruce Smith ND (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-7
22. Naylor AR (2011) Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42:e385-e386
23. Okhawa H, Ohishi N, Yagi K (1979) Assay of lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95:351-358
24. Orsu P, Murthy BV, Akula A (2013) Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats. J Neural Transm. doi: 10.1007/s00702-013-0982-4
25. Rock RB, Gekker G, Hu S et al (2004) Role of microglia in central nervous system infections. Clin Microbiol Rev 17:942-964
26. Saito K, Suyama K, Nishida K, Sei Y, Basile AS (1996) Early increases in TNF-alpha, IL-6 and IL-1 beta following transient cerebral ischemia in gerbil brain. Neurosci Lett 206:149-2
27. Sinha K, Chaudhary G, Gupta YK (2002) Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci 71:655-665
28. Thirunavukkarasu M, Penumathsa SV, Koneru S, Juhasz B, Zhan L, Otani H et al (2007) Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43:720-729
29. Tosaki A, Szerdahelyi P, Joo F (1994) Treatment with ranitidine of ischemic brain edema. Eur J Pharmacol 264:455-458
30. Tsuruta R, Fujita M, Ono T et al (2010) Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats. Brain Res 1309:155-3
31. Wang Y, Schmeichel AM, Iida H, Schmelzer JD, Low PA (2005) Ischemia-reperfusion injury causes oxidative stress and apoptosis of Schwann cell in acute and chronic experimental diabetic neuropathy. Antioxid Redox Signal 7:1513-1520
32. Wong CH, Crack PJ (2008) Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem 15:1-14
33. Yasuda Y, Shimoda T, Uno K et al (2011) Temporal and sequential changes of glial cells and cytokine expression during neuronal degeneration after transient global ischemia in rats. J Neuroinflammation 8:70
34. Yousuf S, Atif F, Ahmad M et al (2007) Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus. Brain Res 1147:218-225
35. Zhang F, Liu J, Shi JS (2010) Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation. Eur J Pharmacol 636:1-7