The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial CRαβ+ CD8αα+ cells

Nature Communications

Volumn 4, Issue , 2013, Pages

  Nakajima, Kohei ^a   Maekawa, Yoichi ^a   Kataoka, Keiko ^a   Ishifune, Chieko ^a   Nishida, Jun ^a   Arimochi, Hideki ^a   Kitamura, Akiko ^a   Yoshimoto, Takayuki ^b   Tomita, Shuhei ^c   Nagahiro, Shinji ^a   Yasutomo, Koji ^a,d  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CD8 ANTIGEN; INTERLEUKIN 15; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

BIOCHEMISTRY; ENVIRONMENTAL FACTOR; GENE EXPRESSION; IMMUNE SYSTEM; MOLECULAR ANALYSIS; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBIOTIC THERAPY; ARTICLE; CELL FATE; CELL STIMULATION; INTESTINE EPITHELIUM CELL; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; REGULATORY MECHANISM; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD8; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BETA-NAPHTHOFLAVONE; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; INTERLEUKIN-15; INTESTINAL MUCOSA; INTESTINES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRECURSOR CELLS, T-LYMPHOID; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84880260699     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3112     Document Type: Article

References (35)

1. Probert, C. S., Saubermann, L. J., Balk, S. & Blumberg, R. S. Repertoire of the alpha beta T-cell receptor in the intestine. Immunol. Rev. 215, 215-225 (2007). (Pubitemid 46212242)
2. Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445-456 (2011).
3. Poussier, P., Ning, T., Banerjee, D. & Julius, M. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195, 1491-1497 (2002). (Pubitemid 34602826)
4. Ostanin, D. V., Brown, C. M., Gray, L., Bharwani, S. & Grisham, M. B. Evaluation of the immunoregulatory activity of intraepithelial lymphocytes in a mouse model of chronic intestinal inflammation. Int. Immunol. 22, 927-939 (2010).
5. McIntosh, B. E., Hogenesch, J. B. & Bradfield, C. A. Mammalian Per-Arnt-Sim proteins in environmental adaptation. Annu. Rev. Physiol. 72, 625-645 (2010).
6. Veldhoen, M. & Duarte, J. H. The aryl hydrocarbon receptor: fine-tuning the immune-response. Curr. Opin. Immunol. 22, 747-752 (2010).
7. Gordan, J. D. & Simon, M. C. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr. Opin. Genet. Dev. 17, 71-77 (2007). (Pubitemid 46109295)
8. Esser, C., Rannug, A. & Stockinger, B. The aryl hydrocarbon receptor in immunity. Trends Immunol. 30, 447-454 (2009).
9. Veldhoen, M. et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109 (2008). (Pubitemid 351630329)
10. Zenewicz, L. A. & Flavell, R. A. Recent advances in IL-22 biology. Int. Immunol. 23, 159-163 (2011).
11. Alam, M. S. et al. Notch signaling drives IL-22 secretion in CD4\+ T cells by stimulating the aryl hydrocarbon receptor. Proc. Natl Acad. Sci. USA 107, 5943-5948 (2010).
12. Li, Y. et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147, 629-640 (2011).
13. Schluns, K. S., Stoklasek, T. & Lefrancois, L. The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both? Int. J. Biochem. Cell Biol. 37, 1567-1571 (2005). (Pubitemid 40719636)
14. Sakai, K. & Miyazaki, J. A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem. Biophys. Res. Commun. 237, 318-324 (1997). (Pubitemid 27406027)
15. Maekawa, Y. et al. Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat. Immunol. 9, 1140-1147 (2008).
16. Suzuki, H., Jeong, K. I., Itoh, K. & Doi, K. Regional variations in the distributions of small intestinal intraepithelial lymphocytes in germ-free and specific pathogen-free mice. Exp. Mol. Pathol. 72, 230-235 (2002).
17. Gangadharan, D. et al. Identification of pre-and postselection TCRalphabeta\+ intraepithelial lymphocyte precursors in the thymus. Immunity 25, 631-641 (2006). (Pubitemid 44529038)
18. Ma, L. J., Acero, L. F., Zal, T. & Schluns, K. S. Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J. Immunol. 183, 1044-1054 (2009).
19. Lai, Y. G. et al. IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha\+ IELs in the intestine. J. Immunol. 180, 3757-3765 (2008).
20. Jiang, W., Ferrero, I., Laurenti, E., Trumpp, A. & MacDonald, H. R. c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival. Blood 115, 4431-4438 (2010).
21. Budagian, V., Bulanova, E., Paus, R. & Bulfone-Paus, S. IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev. 17, 259-280 (2006). (Pubitemid 44038618)
22. Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489 (2010).
23. Lambolez, F., Kronenberg, M. & Cheroutre, H. Thymic differentiation of TCR alpha beta(\+) CD8 alpha alpha(\+) IELs. Immunol. Rev. 215, 178-188 (2007). (Pubitemid 46212239)
24. Furumatsu, K. et al. A role of the aryl hydrocarbon receptor in attenuation of colitis. Dig. Dis. Sci. 56, 2532-2544 (2011).
25. Monteleone, I. et al. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology 141, 237-248, 248 e231 (2011).
26. Takamura, T. et al. Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunol. Cell Biol. 89, 817-822 (2011).
27. Sen, M. et al. First-in-human trial of a STAT3 decoy oligonucleotide abrogates target gene expression in head and neck tumors: implications for cancer therapy. Cancer Discov. 2, 694-705 (2012).
28. Miyoshi, K. et al. Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor. J. Invest. Dermatol. 131, 108-117 (2011).
29. Tomita, S., Sinal, C. J., Yim, S. H. & Gonzalez, F. J. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol. Endocrinol. 14, 1674-1681 (2000).
30. Tomita, S. et al. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol. Cell. Biol. 23, 6739-6749 (2003). (Pubitemid 37214645)
31. Takeda, K. et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl Acad. Sci. USA 94, 3801-3804 (1997). (Pubitemid 27180453)
32. Burchill, M. A. et al. Distinct effects of STAT5 activation on CD4\+ and CD8\+ T cell homeostasis: development of CD4\+CD25\+ regulatory T cells versus CD8\+ memory T cells. J. Immunol. 171, 5853-5864 (2003). (Pubitemid 37467202)
33. Mimura, J. et al. Loss of teratogenic response to 2,3,7,8- tetrachlorodibenzo-pdioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2, 645-654 (1997). (Pubitemid 127688610)
34. Maekawa, Y. et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4\+ T cells. Immunity 19, 549-559 (2003). (Pubitemid 37311436)
35. Morita, S., Kojima, T. & Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000). (Pubitemid 30398356)