Metacaspases, autophagins and metallocarboxypeptidases: Potential new targets for chemotherapy of the trypanosomiases

Current Medicinal Chemistry

Volumn 20, Issue 25, 2013, Pages 3069-3077

  Alvarez, V E ^a   Niemirowicz, G T ^a   Cazzulo, J J ^a  

^a INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

Autophagin; Carboxypeptidase; Chagas disease; Cysteine proteinase; Inhibitor; Metacaspase; Metallopeptidase; Peptidase; Trypanosoma brucei; Trypanosoma cruzi

Indexed keywords

3 METHYLADENINE; ANTITRYPANOSOMAL AGENT; AUTOPHAGIN; BENZOTHIAZOLE DERIVATIVE; CARBOXYPEPTIDASE; CRUZIPAIN; CRUZIPAIN INHIBITOR; DX 600; METACARBOXYPEPTIDASE; METACASPASE; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIODEGRADATION; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL GROWTH; CHAGAS DISEASE; COMPETITIVE INHIBITION; CONJUGATION; CRYSTAL STRUCTURE; DIFFERENTIATION; DIMERIZATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EPIMASTIGOTE; EUKARYOTIC CELL; GREEN ALGA; HORIZONTAL GENE TRANSFER; IMMUNOFLUORESCENCE; KINETOPLASTID LIFE CYCLE STAGE; KINETOPLASTIDA; LEISHMANIA; LEISHMANIASIS; MEMBRANE VESICLE; NONHUMAN; OXIDATIVE STRESS; PARASITE SURVIVAL; PHYLOGENY; PROMASTIGOTE; PROTEIN DOMAIN; PROTEIN TARGETING; THERMUS AQUATICUS; TRYPANOSOMA; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS; TRYPOMASTIGOTE; WILD TYPE;

CARBOXYPEPTIDASES; CASPASES; COMPUTATIONAL BIOLOGY; HUMANS; PROTOZOAN PROTEINS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

EID: 84880260000     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867311320250004     Document Type: Article

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