Increased early RNA replication by chimeric west nile virus W956IC leads to IPS-1-mediated activation of NF-κB and insufficient virus-mediated counteraction of the resulting canonical type I interferon signaling

Journal of Virology

Volumn 87, Issue 14, 2013, Pages 7952-7965

  Scherbik, S V ^a,b   Pulit Penaloza, J A ^a   Basu, M ^a   Courtney, S C ^a   Brinton, M A ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; BETA INTERFERON PROMOTER STIMULATOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; BETA INTERFERON GENE; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; GENE SWITCHING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA REPLICATION; SIGNAL TRANSDUCTION; VIRUS GENE; VIRUS STRAIN; WEST NILE FLAVIVIRUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; CHIMERA; CRICETINAE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, VIRAL; INTERFERON TYPE I; INTERFERON-BETA; MICE; MICROSCOPY, CONFOCAL; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; VIRUS REPLICATION; WEST NILE VIRUS;

EID: 84880257694     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02842-12     Document Type: Article

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