Direct measurement of active thiol metabolite levels of clopidogrel in human plasma using tris(2-carboxyethyl)phosphine as a reducing agent by LC-MS/MS

Journal of Separation Science

Volumn 36, Issue 14, 2013, Pages 2306-2314

  Park, Jung Bae ^a   Bae, Soo Hyeon ^a   Jang, Su Min ^a   Noh, Won Jun ^b   Hong, Jang Hee ^c,d   Yoon, Kee Dong ^a   Kang, Han Chang ^a   Bae, Soo Kyung ^a  

^a The Catholic University of Korea   (South Korea)

^b Daewon Foreign Language High School   (South Korea)

^c Chungnam National University College of Medicine   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Clopidogrel; Clopidogrel active metabolite; Human plasma; LC MS MS; Reducing agent; tris(2 Carboxyethyl)phosphine

Indexed keywords

ACTIVE METABOLITES; CLOPIDOGREL; HUMAN PLASMAS; LC-MS/MS; TRIS(2 CARBOXYETHYL)PHOSPHINE;

ACETONITRILE; BIOMOLECULES; METABOLITES; MIXTURES; PHOSPHORUS COMPOUNDS; REDUCING AGENTS;

PLASMA (HUMAN);

3 (CARBOXYMETHYLEN) A (2 CHLOROPHENYL) 4 MERCAPTO 1 PIPERIDINEACETIC ACID; ACETONITRILE; BLOOD EXTRACT; CLOPIDOGREL; DRUG METABOLITE; FORMIC ACID; PLASMA PROTEIN; REDUCING AGENT; THIOL; TRIS(2 CARBOXYETHYL)PHOSPHINE; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; CLINICAL ARTICLE; CORRELATION COEFFICIENT; DISULFIDE BOND; DRUG BLOOD LEVEL; DYNAMICS; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; METABOLITE; PRIORITY JOURNAL; STANDARD;

CLOPIDOGREL; CLOPIDOGREL ACTIVE METABOLITE; HUMAN PLASMA; LC-MS/MS; REDUCING AGENT; TRIS(2-CARBOXYETHYL)PHOSPHINE;

CHROMATOGRAPHY, LIQUID; HUMANS; OXIDATION-REDUCTION; PHOSPHINES; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY; TICLOPIDINE;

EID: 84880257644     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201300332     Document Type: Article

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