A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 880, Issue 1, 2012, Pages 132-139

  Peer, Cody J ^a   Spencer, Shawn D ^b   VanDenBerg, Dustin A H ^a   Pacanowski, Michael A ^c   Horenstein, Richard B ^d   Figg, William D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Active metabolite; Clopidogrel; Ultra HPLC MS MS

Indexed keywords

ACETOPHENONES; ACQUITY; ACTIVE METABOLITES; ANALYTES; ANALYTICAL METHOD; CLOPIDOGREL; CONCENTRATION RANGES; DERIVATIZATIONS; GRADIENT ELUTION; HPLC-MS/MS; HUMAN PLASMAS; INTERNAL STANDARDS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; METHOXY; ORAL DOSE; PHARMACOKINETIC STUDIES; PLASMA CONCENTRATION; PROTEIN PRECIPITATION; RUNTIMES; SAMPLE HANDLING; SIMULTANEOUS DETECTION; ULTRA-HIGH PERFORMANCE;

BIOMOLECULES; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KETONES; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN); PLASMAS;

METABOLISM;

CLOPIDOGREL; DRUG METABOLITE;

ARTICLE; DRUG STABILITY; ELECTROSPRAY; ELUTION; FREEZE THAWING; HUMAN; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; PLASMA; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY; TICLOPIDINE;

EID: 84855199955     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.11.029     Document Type: Article

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