A new horizon: Oxytocin as a novel therapeutic option for obesity and diabetes

Drug Discovery Today: Disease Mechanisms

Volumn 10, Issue 1-2, 2013, Pages

  Cai, Dongsheng ^a   Purkayastha, Sudarshana ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OXYTOCIN;

BODY WEIGHT; BRAIN REGION; DIABETES MELLITUS; DRUG EFFICACY; FEEDING BEHAVIOR; GENETIC MANIPULATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HUMAN; HYPOTHALAMUS; INSULIN RELEASE; LIPOLYSIS; METABOLIC DISORDER; METABOLIC REGULATION; NONHUMAN; OBESITY; REPRODUCTION; REVIEW; SOCIAL BEHAVIOR; WEIGHT REDUCTION;

EID: 84880208775     PISSN: None     EISSN: 17406765     Source Type: Journal    
DOI: 10.1016/j.ddmec.2013.05.006     Document Type: Review

References (50)

1. R.E. Amori Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis JAMA 298 2007 194 206
2. M. Briones, and M. Bajaj Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus Expert. Opin. Pharmacother. 7 2006 1055 1064
3. M.W. Schwartz, and D. Porte Jr. Diabetes, obesity, and the brain Science 307 2005 375 379
4. D. Cai, and T. Liu Hypothalamic inflammation: a double-edged sword to nutritional diseases Ann. N. Y. Acad. Sci. 1243 2011 E1 E39
5. D. Cai, and T. Liu Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB Aging (Albany, NY) 4 2012 98 115
6. J.K. Elmquist, and J.S. Flier Neuroscience. The fat-brain axis enters a new dimension Science 304 2004 63 64
7. J.S. Flier, and E. Maratos-Flier Obesity and the hypothalamus: novel peptides for new pathways Cell 92 1998 437 440
8. J.N. Ferguson Social amnesia in mice lacking the oxytocin gene Nat. Genet. 25 2000 284 288
9. M. Kosfeld Oxytocin increases trust in humans Nature 435 2005 673 676
10. A. Argiolas, and G.L. Gessa Central functions of oxytocin Neurosci. Biobehav. Rev. 15 1991 217 231
11. K. MacDonald, and T.M. Macdonald The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans Harv. Rev. Psychiatry 18 2010 1 21
12. J.E. Blevins Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size Am. J. Physiol Regul. Integr. Comp Physiol 287 2004 R87 R96
13. C. Blouet Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit J. Neurosci. 29 2009 8302 8311
14. D.G. Baskin A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain Endocrinology 151 2010 4207 4213
15. G. Zhang, and D. Cai Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment Am. J. Physiol Endocrinol. Metab 301 2011 E1004 E1012
16. G. Zhang Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance Neuron 69 2011 523 535
17. H. Zhang Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models PLoS ONE 8 2013 e61477
18. N. Deblon Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats PLoS ONE 6 2011 e25565
19. Y. Maejima Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass Aging (Albany, NY) 3 2011 1169 1177
20. G. Gimpl, and F. Fahrenholz The oxytocin receptor system: structure, function, and regulation Physiol. Rev. 81 2001 629 683
21. T.R. Insel Central oxytocin and reproductive behaviours Rev. Reprod. 2 1997 28 37
22. C.S. Carter Oxytocin and sexual behavior Neurosci. Biobehav. Rev. 16 1992 131 144
23. D.M. Witt, and T.R. Insel A selective oxytocin antagonist attenuates progesterone facilitation of female sexual behavior Endocrinology 128 1991 3269 3276
24. A. Meyer-Lindenberg Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine Nat. Rev. Neurosci. 12 2011 524 538
25. D. Feifel Oxytocin as a potential therapeutic target for schizophrenia and other neuropsychiatric conditions Neuropsychopharmacology 37 2012 304 305
26. X. Zhang Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity Cell 135 2008 61 73
27. A.P. Coll The hormonal control of food intake Cell 129 2007 251 262
28. M.W. Schwartz Central nervous system control of food intake Nature 404 2000 661 671
29. A.J. Douglas Neuroendocrine mechanisms of change in food intake during pregnancy: a potential role for brain oxytocin Physiol. Behav. 91 2007 352 365
30. G. Leng Oxytocin and appetite Prog. Brain Res. 170 2008 137 151
31. J.M. Ho, and J.E. Blevins Coming full circle: contributions of central and peripheral oxytocin actions to energy balance Endocrinology 154 2013 589 596
32. R. Arletti Influence of oxytocin on feeding behavior in the rat Peptides 10 1989 89 93
33. C.M. Lokrantz Effects of central oxytocin administration on intraoral intake of glucose in deprived and nondeprived rats Physiol. Behav. 62 1997 347 352
34. L.E. Johnstone Neuronal activation in the hypothalamus and brainstem during feeding in rats Cell Metab. 4 2006 313 321
35. J.G. Verbalis Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety Science 232 1986 1417 1419
36. B.M. Kublaoui Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice Mol. Endocrinol. 22 2008 1723 1734
37. J.A. Amico Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion Am. J. Physiol Regul. Integr. Comp Physiol 289 2005 R1798 R1806
38. Y. Takayanagi Oxytocin receptor-deficient mice developed late-onset obesity Neuroreport 19 2008 951 955
39. M. Ludwig, and G. Leng Dendritic peptide release and peptide-dependent behaviours Nat. Rev. Neurosci. 7 2006 126 136
40. B.M. Kublaoui Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons Mol. Endocrinol. 20 2006 2483 2492
41. K.P. Tolson Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression J. Neurosci. 30 2010 3803 3812
42. D.F. Swaab Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases J. Clin. Endocrinol. Metab. 80 1995 573 579
43. J.T. Littleton Synaptic function modulated by changes in the ratio of synaptotagmin I and IV Nature 400 1999 757 760
44. G.J. Morton Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats Am. J. Physiol. Endocrinol. Metab. 302 2012 E134 E144
45. J. Knudtzon Acute effects of oxytocin and vasopressin on plasma levels of glucagon, insulin and glucose in rabbits Horm. Metab. Res. 15 1983 103 104
46. S. Stock, and K. Uvnas-Moberg l-Vasopressin inhibits oxytocin-induced increases of plasma levels of insulin in conscious dogs Acta Physiol. Scand. 130 1987 55 61
47. N. Altszuler Role of insulin and glucagon in oxytocin effects on glucose metabolism Proc. Soc. Exp. Biol. Med. 199 1992 236 242
48. G. Paolisso Effects of oxytocin delivery on counter-regulatory hormone response in insulin-dependent (type 1) diabetic subjects Horm. Res. 31 1989 250 255
49. R.A. Adan Mechanisms underlying current and future anti-obesity drugs Trends Neurosci. 36 2013 133 140
50. D. Feifel Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients Biol. Psychiatry 68 2010 678 680