Epigenetics and personalized medicine: Prospects and ethical issues

Personalized Medicine

Volumn 10, Issue 5, 2013, Pages 463-471

  Chadwick, Ruth ^a   Oconnor, Alan ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

cancer; epigenetic drugs; epigenetic therapy; epigenetics; ethics; obesity; responsibility; transgenerational justice

Indexed keywords

BIOETHICS; CLINICAL PRACTICE; DNA METHYLATION; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE DELIVERY; HUMAN; MATERNAL BEHAVIOR; OBESITY; PERSONALIZED MEDICINE; POLLUTION; PRIORITY JOURNAL; RESPONSIBILITY; REVIEW; SOCIAL BEHAVIOR; WEIGHT GAIN;

EID: 84880199246     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme.13.35     Document Type: Review

References (50)

1. Robertson KD. DNA methylation and human disease. Nat. Rev. Genet. 6(8), 597-610 (2005
2. Hackett JA, Sengupta R, Zylicz JJ et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 339(6118), 448-452 (2013
3. Meaney MJ. Epigenetics and the biological definition of gene × environment interactions. Child Dev. 81(1), 41-79 (2010
4. Weaver IC, Cervoni N, Champagne FA et al. Epigenetic programming by maternal behavior. Nat. Neurosci. 7(8), 847-854 (2004
5. Roth TL. Epigenetics of neurobiology and behavior during development and adulthood. Dev. Psychobiol. 54(6), 590-597 (2012
6. Feinberg AP, Irizarry RA. Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc. Natl Acad. Sci. USA 107(Suppl. 1), S1757-S1764 (2010
7. Guthman J, Mansfield B. The implications of environmental epigenetics: A new direction for geographic inquiry on health, space, and nature-society relations. Prog. Hum. Geogr. doi:10.1177/0309132512463258 (2012) (Epub ahead of print
8. Esteller M. Epigenetics in cancer. N. Engl. J. Med. 358(11), 1148-1159 (2008
9. Sato N, Matsubayashi H, Fukushima N, Goggins M. The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer. Cancer Biol. Ther. 4(1), 70-76 (2005
10. Feinberg AP, Irizarry RA, Fradin D et al. Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci. Transl. Med. 2(49), 49ra67 (2010
11. Schones DE, Zhao K. Genome-wide approaches to studying chromatin modifications. Nat. Rev. Genet. 9(3), 179-191 (2008
12. Li J, Zhao Q, Bolund L Computational methods for epigenetic analysis: The protocol of computational analysis for modified methylation-specific digital karyotyping based on massively parallel sequencing. In: Epigenetics Protocols. Tollefsbol TO (Ed.). Humana Press, NY, USA, 313-328 (2011
13. Statham AL, Robinson MD, Song JZ, Coolen MW, Stirzaker C, Clark SJ. Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res. 22(6), 1120-1127 (2012
14. Brinkman AB, Gu H, Bartels SJJ et al. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-Talk. Genome Res. 22(6), 1128-1138 (2012
15. Weber WW. The promise of epigenetics in personalized medicine. Mol. Interv. 10(6), 363-370 (2011
16. Budiman MA, Smith SW, Ordway JM. DNA methylation in personalized medicine. Pers. Med. 8(1), 35-43 (2011
17. Peedicayil J. The epigenome in personalized medicine. Clin. Pharmacol. Ther. 93, 149-150 (2013
18. Shastry BS. Role of epigenomics in drug discovery and therapies. Drug Dev. Res. 73(8), 513-517 (2012
19. Kalozoumi G, Tzimas C, Sanoudou D. The expanding role of epigenetics. Global Cardiol. Sci. Pract. 2012(1), 7 (2012
20. Gomez A, Ingelman-Sundberg M. Pharmacoepigenetics: Its role in interindividual differences in drug response. Clin. Pharmacol. Ther. 85(4), 426-430 (2009
21. Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 116(3), 496-526 (2007
22. Kacevska M, Ivanov M, Wyss A et al. DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie 94(11), 2338-2344 (2012
23. Kussmann M, Krause L, Siffert W. Nutrigenomics: Where are we with genetic and epigenetic markers for disposition and susceptibility? Nutr. Rev. 68(Suppl. 1), S38-S47 (2010
24. Mack GS. To selectivity and beyond. Nat. Biotechnol. 28(12), 1259-1266 (2010
25. Foulks JM, Parnell KM, Nix RN et al. Epigenetic drug discovery targeting DNA methyltransferases. J. Biomol. Screen. 17(1), 2-17 (2012
26. Rothstein MA, Cai Y, Marchant GE. The ghost in our genes: Legal and ethical implications of epigenetics. Health Matrix Clevel. 19(1), 1-62 (2009
27. Lillycrop KA, Burdge GC. Epigenetic changes in early life and future risk of obesity. Int. J. Obes. 35(1), 72-83 (2011
28. Husted J. Autonomy and a right not to know. In: The Right to Know and the Right Not to Know. Chadwick R, Levitt M, Shickle D (Eds). Avebury, Aldershot, UK, 55-68 (1997
29. Chadwick R. Nutrigenomics, individualism and public health. Proc. Nutr. Soc. 63(01), 161-166 (2004
30. Davis DS. Genetic dilemmas and the child's right to an open future. Rutgers Law J. 28, 549 (1997
31. Groves C. Future ethics: Risk, care and non-reciprocal responsibility. J. Global Ethics 5(1), 17-31 (2009
32. McCarthy MI. Genomics, Type 2 diabetes, and obesity. N. Engl. J. Med. 363(24), 2339-2350 (2010
33. Jiménez-Chillarón JC, Díaz R, Martínez D et al. The role of nutrition on epigenetic modifications and their implications on health. Biochimie 94(11), 2242-2263 (2012
34. Martínez JA, Cordero P, Campión J, Milagro FI. Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. Proc. Nutr. Soc. 71(02), 276-283 (2012
35. Swierstra T. Behaviour, environment or body: Three discourses on obesity. In: Genomics, Obesity and the Struggle Over Responsibilities. Korthals M (Ed.) Springer, NY, USA, 27-38 (2011
36. van den Belt H. Contesting the obesity 'epidemic': Elements of a counter discourse. In: Genomics, Obesity and the Struggle Over Responsibilities. Korthals M (Ed.) Springer, NY, USA, 39-58 (2011
37. Hedlund M. Epigenetic responsibility. Med. Stud. 3(3), 171-183 (2011
38. Daar AS, Singer PA. Pharmacogenetics and geographical ancestry: Implications for drug development and global health. Nat. Rev. Genet. 6(3), 241-246 (2005
39. Blank H, Musch J, Pohl RF. Hindsight bias: On being wise after the event. Soc. Cognition 25(1), 1-9 (2007
40. Pennington DC. Being wise after the event: An investigation of hindsight bias. Curr. Psychol. Res. 1(3-4), 271-282 (1981
41. Ma YT, Collins SI, Young LS, Murray PG, Woodman CB. Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: A longitudinal study. Br. J. Cancer 104(9), 1500-1504 (2011
42. Wiener CJ. Transgenerational tort liability for epigenetic disease. DePaul J. Health Care L. 13, 319 (2010
43. Vickers MH, Gluckman PD, Coveny AH et al. Neonatal leptin treatment reverses developmental programming. Endocrinology 146(10), 4211-4216 (2005
44. Gesche AH. Taking a first step: Epigenetic health and responsibility. In: Epigenetics and Human Health. Haslberger AG (Ed). Wiley-VCH Verlag GmbH & Co., NY, USA, 281-285 (2010
45. Perera F, Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reprod. Toxicol. 31(3), 363-373 (2011
46. Khan F. Preserving human potential as freedom: A framework for regulating epigenetic harms. Health Matrix Clevel. 20(2), 259-323 (2010
47. Prainsack B, Buyx A. Solidarity: Reflections on an Emerging Concept in Bioethics. Nuffield Foundation, Swindon, UK (2011
48. Williams G, Chadwick R. Responsibilities for healthcare. Camb. Q. Healthcare Ethics 21(02), 155-165 (2012
49. Thaler RH, Sunstein CR. Nudge: Improving Decisions About Health, Wealth, And Happiness. Yale University Press, CT, USA (2008
50. Venkatapuram S. Health Justice: An Argument From The Capabilities Approach (1st Edition). Polity Press, Cambridge, UK.