Ketamine-induced ventricular structural, sympathetic and electrophysiological remodelling: Pathological consequences and protective effects of metoprolol

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1748-1756

  Li, Y ^a   Shi, J ^a   Yang, B F ^a   Liu, L ^a   Han, C L ^a   Li, W M ^a   Dong, D L ^a   Pan, Z W ^a   Liu, G Z ^a   Geng, J Q ^a   Sheng, L ^a   Tan, X Y ^a   Sun, D H ^a   Gong, Z H ^a   Gong, Y T ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

cardiac remodelling; ketamine; malignant arrhythmia; metoprolol; sudden cardiac death

Indexed keywords

COLLAGEN; KETAMINE; METOPROLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG MECHANISM; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE CONDUCTION; LONG TERM CARE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; TISSUE LEVEL; TREATMENT DURATION;

EID: 84863123587     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01635.x     Document Type: Article

References (33)

1. Ablad B, Bjurö T, Björkman JA, Edström T, (2007). Prevention of ventricular fibrillation requires central beta-adrenoceptor blockade in rabbits. Scand Cardiovasc J 41: 221-229.
2. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th Edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
3. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, et al,. (2000). Nerve sprouting and sudden cardiac death. Circ Res 86: 816-821.
4. Chakravarthy B, Rashid A, Brown L, Tessier L, Kelly J, Ménard M, (2008). Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells. Biochem Biophys Res Commun 371: 679-683.
5. Dillon P, Copeland J, Jansen K, (2003). Patterns of use and harms associated with non-medical ketamine use. Drug Alcohol Depend 69: 23-28.
6. Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G, et al,. (2009). Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. Circ Heart Fail 2: 233-242.
7. Gong YT, Li WM, Li Y, Yang SS, Sheng L, Yang N, et al,. (2009). Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Chin Med J (Engl) 122: 74-82.
8. Huang D, Wang Y, Yang C, Liao Y, Huang K, (2009). Angiotensin ? promotes poly(ADP-ribosyl)ation of c-Jun/c-Fos in cardiac fibroblasts. J Mol Cell Cardiol 46: 25-32.
9. Hurley RJ, Marini RP, Avison DL, Murphy JC, Olin JM, Lipman NS, (1994). Evaluation of detomidine anesthetic combinations in the rabbit. Lab Anim Sci 44: 472-478.
10. Imai M, Rastogi S, Gupta RC, Mishra S, Sharov VG, Stanley WC, et al,. (2007). Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J Am Coll Cardiol 49: 2120-2128.
11. Jiang H, Lu Z, Yu Y, Zhao D, Jian X, Yang B, et al,. (2007). Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. Cardiology 108: 176-182.
12. Kamphoven JH, Stubenitsky R, Reuser AJ, Van Der Ploeg AT, Verdouw PD, Duncker DJ, (2001). Cardiac remodeling and contractile function in acid alpha-glucosidase knockout mice. Physiol Genomics 5: 171-179.
13. Kang YH, Yi MJ, Kim MJ, Park MT, Bae S, Kang CM, et al,. (2004). Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Res 64: 8960-8967.
14. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD, (1995). Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 26: 1257-1263.
15. Kraus WL, Lis JT, (2003). PARP goes transcription. Cell 113: 677-683.
16. Licata M, Pierini G, Popoli G, (1994). A fatal keatmine poisoning. J Forensic Sci 39: 1314-1320.
17. Lockhart ST, Turrigiano GG, Birren SJ, (1997). Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. J Neurosci 17: 9573-9582.
18. Marini RP, Li X, Harpster NK, Dangler C, (1999). Cardiovascular pathology possibly associated with ketamine/xylazine anesthesia in Dutch belted rabbits. Lab Anim Sci 49: 153-160.
19. Meredith IT, Broughton A, Jennings GL, Esler MD, (1991). Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med 325: 618-624.
20. Ng SH, Tse ML, Ng HW, Lau FL, (2010). Emergency department presentation of ketamine abusers in Hong Kong: a review of 233 cases. Hong Kong Med J 16: 6-11.
21. Pillai JB, Gupta M, Rajamohan SB, Lang R, Raman J, Gupta MP, (2006). Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol 291: H1545-H1553.
22. Salaun C, Leroy C, Rousseau A, Boitez V, Beck L, Friedlander G, (2010). Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. J Biol Chem 285: 34408-34418.
23. Smith KM, Larive LL, Romanelli F, (2002). Club drugs: methylenedioxymethamphetamine, flunitrazepam, ketamine hydrochloride, and gamma-hydroxybutyrate. Am J Health Syst Pharm 59: 1067-1076.
24. Sun LP, Wang L, Wang H, Zhang YH, Pu JL, (2010). Connexin 43 remodeling induced by LMNA gene mutation Glu82Lys in familial dilated cardiomyopathy with atrial ventricular block. Chin Med J (Engl) 123: 1058-1062.
25. Tao Y, Chen XP, Qin ZH, (2005). A fatal chronic ketamine poisoning. J Forensic Sci 50: 173-176.
26. Trujillo KA, Zamora JJ, Warmoth KP, (2008). Increased response to ketamine following treatment at long intervals: implications for intermittent use. Biol Psychiatry 63: 178-183.
27. van der Velden J, Merkus D, Klarenbeek BR, James AT, Boontje NM, Dekkers DH, et al,. (2004). Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction. Circ Res 95: e85-e95.
28. Vento P, Kiviluoto T, Keränen U, Järvinen HJ, Kivilaakso E, Soinila S, (2001). Quantitative comparison of growth-associated protein-43 and substance P in ulcerative colitis. J Histochem Cytochem 49: 749-758.
29. Weiner AL, Vieira L, McKay CA, Bayer MJ, (2000). Ketamine abusers presenting to the emergency department: a case series. J Emerg Med 18: 447-451.
30. Wernli G, Hasan W, Bhattacherjee A, van Rooijen N, Smith PG, (2009). Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction. Basic Res Cardiol 104: 681-693.
31. Wu J, Wu YS, Zhao CY, (2007). Effects of ketamine on apoptosis and expression of Fas and Bcl-2 protein in rats with experimental myocardial ischemia/reperfusion injury. Shu Li Yi Yao Xue Za Zhi 20: 18-20.
32. Yang SS, Han W, Zhou HY, Dong G, Wang BC, Huo H, et al,. (2008). Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs. Chin Med J (Engl) 121: 38-42.
33. Yuan MJ, Huang CX, Tang YH, Wang X, Huang H, Chen YJ, et al,. (2009). A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats. Eur J Pharmacol 618: 52-57.