Novel temperature-triggered liposome with high stability: Formulation, in vitro evaluation, and in vivo study combined with high-intensity focused ultrasound (HIFU)

Journal of Controlled Release

Volumn 170, Issue 3, 2013, Pages 373-379

  Park, Sun Min ^a   Kim, Min Sang ^a   Park, Sang Jun ^a   Park, Eun Sung ^a   Choi, Kyu Sil ^b   Kim, Young Sun ^c   Kim, Hyun Ryoung ^a  

^a Samsung Advanced Institute of Technology (SAIT)   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Drug delivery system; Elastin like polypeptide; Heat triggered drug release; Mild hyperthermia; Thermosensitive liposome

Indexed keywords

CARDIOVASCULAR SYSTEM; DRUG PRODUCTS; DRUG THERAPY; ELASTIN; FATTY ACIDS; GLYCOPROTEINS; GRADIENT METHODS; LIPOSOMES; TEMPERATURE; TUMORS; ULTRASONICS;

DRUG DELIVERY SYSTEM; ELASTIN-LIKE POLYPEPTIDES; MILD HYPERTHERMIA; THERMOSENSITIVE LIPOSOMES; TRIGGERED DRUG RELEASE;

POLYPEPTIDES;

1,2 DISTEAROYL SN GLYCERO 3 PHOSPHOETHANOLAMINE N [METHOXY(POLYETHYLENEGLYCOL) 2000]; AMMONIUM SULFATE; CHOLESTEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; DOXORUBICIN; ELASTIN; LIPOSOME; MACROGOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER REGRESSION; CANCER SIZE; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CIRCULATION TIME; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; FEMALE; HEAT SENSITIVITY; HIGH INTENSITY FOCUSED ULTRASOUND; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL DELIVERY; LOW TEMPERATURE; MALE; MOLECULAR SIZE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; THERMOSTABILITY; ULTRASOUND TRANSDUCER;

DRUG DELIVERY SYSTEM; ELASTIN-LIKE POLYPEPTIDE; HEAT-TRIGGERED DRUG RELEASE; MILD HYPERTHERMIA; THERMOSENSITIVE LIPOSOME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; COMBINED MODALITY THERAPY; DOXORUBICIN; HELA CELLS; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; HUMANS; LIPIDS; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; NEOPLASMS; TEMPERATURE; TUMOR BURDEN;

EID: 84880181667     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.06.003     Document Type: Article

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