Advances in murine models of diabetic nephropathy

Journal of Diabetes Research

Volumn 2013, Issue , 2013, Pages

  Kong, Li Li ^a   Wu, Hao ^a   Cui, Wen Peng ^a   Zhou, Wen Hua ^a   Luo, Ping ^a   Sun, Jing ^a   Yuan, Hang ^a   Miao, Li Ning ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALLOXAN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; STREPTOZOCIN;

ALBUMINURIA; ALLOXAN DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE MODEL; GOTO KAKIZAKI RAT; HUMAN; HYPERGLYCEMIA; INSULIN 2 AKITA MOUSE; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; KK AY MOUSE; KNOCKOUT MOUSE; MOUSE STRAIN; NEW ZEALAND OBESE MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NONOBESE DIABETIC MOUSE; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; OVE26 MOUSE; PRIORITY JOURNAL; REVIEW; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; ZUCKER DIABETIC FATTY RAT; ANIMAL; DISEASE COURSE; EXPERIMENTAL DIABETES MELLITUS; MOUSE; PATHOPHYSIOLOGY;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; MICE;

EID: 84880176404     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2013/797548     Document Type: Review

References (84)

1. Szkudelski T., The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiological Research 2001 50 6 537 546 2-s2.0-0035691617
2. Lenzen S., The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008 51 2 216 226 2-s2.0-37549029242 10.1007/s00125-007- 0886-7
3. Susztak K., Sharma K., Schiffer M., McCue P., Ciccone E., Böttinger E. P., Genomic strategies for diabetic nephropathy. Journal of the American Society of Nephrology 2003 14 3 S271 S278 2-s2.0-0042867398
4. Tesch G. H., Allen T. J., Rodent models of streptozotocin-induced diabetic nephropathy (methods in renal research). Nephrology 2007 12 3 261 266 2-s2.0-34248216953 10.1111/j.1440-1797.2007.00796.x
5. Itagaki S., Nishida E., Lee M.-J., Doi K., Histopathology of subacute renal lesions in mice induced by streptozotocin. Experimental and Toxicologic Pathology 1995 47 6 485 491 2-s2.0-0029615487
6. Farr A. G., Mannschreck J. W., Anderson S. K., Expression of Ia antigens by murine kidney epithelium after exposure to streptozotocin. American Journal of Pathology 1987 126 3 561 568 2-s2.0-0023105917
7. Schmezer P., Eckert C., Liegibel U. M., Tissue-specific induction of mutations by streptozotocin in vivo. Mutation Research 1994 307 2 495 499 2-s2.0-0028271775 10.1016/0027-5107(94)90260-7
8. Hall-Craggs M., Brenner D. E., Vigorito R. D., Sutherland J. C., Acute renal failure and renal tubular squamous metaplasia following treatment with streptozotocin. Human Pathology 1982 13 6 597 601 2-s2.0-0019946406
9. Tay Y., Wang Y., Kairaitis L., Rangan G. K., Zhang C., Harris D. C. H., Can murine diabetic nephropathy be separated from superimposed acute renal failure? Kidney International 2005 68 1 391 398 2-s2.0-24944442608 10.1111/j.1523-1755.2005.00405.x
10. Breyer M. D., Bottinger E., Brosius F. C. III, Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology 2005 16 1 27 45
11. Kraynak A. R., Storer R. D., Jensen R. D., Kloss M. W., Soper K. A., Clair J. H., DeLuca J. G., Nichols W. W., Eydelloth R. S., Extent and persistence of streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays. Toxicology and Applied Pharmacology 1995 135 2 279 286 2-s2.0-0029566291 10.1006/taap.1995.1234
12. Leiter E. H., Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex, and thymus. Proceedings of the National Academy of Sciences of the United States of America 1982 79 2 630 634 2-s2.0-0020024396
13. Leiter E. H., Differential susceptibility of BALB/c sublines to diabetes induction by multi-dose streptozotocin treatment. Current Topics in Microbiology and Immunology 1985 122 78 85 2-s2.0-0021775748
14. Sun S., Wang Y., Li Q., Tian Y., Liu M., Yu Y., Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Chinese Medical Journal 2006 119 10 814 821 2-s2.0-33744474294
15. Like A. A., Appel M. C., Williams R. M., Rossini A. A., Streptozotocin-induced pancreatic insulitis in mice morphologic and physiologic studies. Laboratory Investigation 1978 38 4 470 486 2-s2.0-0018154687
16. Like A. A., Rossini A. A., Streptozotocin induced pancreatic insulitis: new model of diabetes mellitus. Science 1976 193 4251 415 417 2-s2.0-0017179001
17. Rossini A. A., Appel M. C., Williams R. M., Like A. A., Genetic influence of the streptozotocin-induced insulitis and hyperglycemia. Diabetes 1977 26 10 916 920 2-s2.0-0017691490
18. Gurley S. B., Clare S. E., Snow K. P., Hu A., Meyer T. W., Coffman T. M., Impact of genetic background on nephropathy in diabetic mice. American Journal of Physiology 2006 290 1 F214 F222 2-s2.0-33644802764 10.1152/ajprenal.00204. 2005
19. Huang W., Gallois Y., Bouby N., Bruneval P., Heudes D., Belair M., Krege J. H., Meneton P., Marre M., Smithies O., Alhenc-Gelas F., Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse. Proceedings of the National Academy of Sciences of the United States of America 2001 98 23 13330 13334 2-s2.0-0035818501 10.1073/pnas.231476798
20. Susztak K., Böttinger E., Novetsky A., Liang D., Zhu Y., Ciccone E., Wu D., Dunn S., McCue P., Sharma K., Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes 2004 53 3 784 794 2-s2.0-10744223171 10.2337/diabetes.53.3.784
21. Surwit R. S., Feinglos M. N., Rodin J., Sutherland A., Petro A. E., Opara E. C., Kuhn C. M., Rebuffe-Scrive M., Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 1995 44 5 645 651 2-s2.0-0029065480
22. Surwit R. S., Kuhn C. M., Cochrane C., McCubbin J. A., Feinglos M. N., Diet-induced type II diabetes in C57BL/6J mice. Diabetes 1988 37 9 1163 1167 2-s2.0-0024229140
23. Petro A. E., Cotter J., Cooper D. A., Peters J. C., Surwit S. J., Surwit R. S., Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse. Metabolism 2004 53 4 454 457 2-s2.0-1842584230 10.1016/j.metabol.2003.11.018
24. Schreyer S. A., Wilson D. L., Leboeuf R. C., C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. Atherosclerosis 1998 136 1 17 24 2-s2.0-0031852458 10.1016/S0021-9150(97)00165-2
25. Towler D. A., Bidder M., Latifi T., Coleman T., Semenkovich C. F., Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. Journal of Biological Chemistry 1998 273 46 30427 30434 2-s2.0-0032515059 10.1074/jbc.273.46.30427
26. Mu J., Naggert J. K., Svenson K. L., Collin G. B., Kim J. H., McFarland C., Nishina P. M., Levine D. M., Williams K. J., Paigen B., Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J. Journal of Lipid Research 1999 40 7 1328 1335 2-s2.0-0032807087
27. Sugano M., Yamato H., Hayashi T., Ochiai H., Kakuchi J., Goto S., Nishijima F., Iino N., Kazama J. J., Takeuchi T., Mokuda O., Ishikawa T., Okazaki R., High-fat diet in low-dose-streptozotocin-treated heminephrectomized rats induces all features of human type 2 diabetic nephropathy: a new rat model of diabetic nephropathy. Nutrition, Metabolism and Cardiovascular Diseases 2006 16 7 477 484 2-s2.0-33749053166 10.1016/j.numecd.2005.08.007
28. Makino S., Kunimoto K., Muraoka Y., Mizushima Y., Katagiri K., Tochino Y., Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 1980 29 1 1 13 2-s2.0-0018841766
29. Mathews C. E., Utility of murine models for the study of spontaneous autoimmune type 1 diabetes. Pediatric Diabetes 2005 6 3 165 177 2-s2.0-24044513266 10.1111/j.1399-543X.2005.00123.x
30. Wicker L. S., Chamberlain G., Hunter K., Rainbow D., Howlett S., Tiffen P., Clark J., Gonzalez-Munoz A., Cumiskey A. M., Rosa R. L., Howson J. M., Smink L. J., Kingsnorth A., Lyons P. A., Gregory S., Rogers J., Todd J. A., Peterson L. B., Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. Journal of Immunology 2004 173 1 164 173 2-s2.0-2942739158
31. Driver J. P., Serreze D. V., Chen Y., Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Seminars in Immunopathology 2011 33 1 67 87 2-s2.0-79251621206 10.1007/s00281-010-0204-1
32. Doi T., Agodoa L. Y. C., Sato T., Yoshida H., Striker L. J., Striker G. E., Hattori M., Glomerular lesions in nonobese diabetic mouse: before and after the onset of hyperglycemia. Laboratory Investigation 1990 63 2 204 212 2-s2.0-0024989937
33. Alpers C. E., Hudkins K. L., Mouse models of diabetic nephropathy. Current Opinion in Nephrology and Hypertension 2011 20 3 278 284 2-s2.0-79955027552 10.1097/MNH.0b013e3283451901
34. Cohen M. P., Lautenslager G. T., Shearman C. W., Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice. Metabolism 2001 50 12 1435 1440 2-s2.0-0035655219 10.1053/meta.2001.28074
35. +-glucose cotransporter inhibitor T-1095. British Journal of Pharmacology 2001 132 2 578 586 2-s2.0-0035122471
36. Mishra R., Emancipator S. N., Miller C., Kern T., Simonson M. S., Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney. American Journal of Physiology 2004 286 5 F913 F921 2-s2.0-1942439127 10.1152/ajprenal.00323.2003
37. Koya D., Haneda M., Nakagawa H., Isshiki K., Sato H., Maeda S., Sugimoto T., Yasuda H., Kashiwagi A., Ways D. K., King G. L., Kikkawa R., Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB Journal 2000 14 3 439 447 2-s2.0-0034053336
38. Moralejo D. H., Ogino T., Zhu M., Toide K., Wei S., Wei K., Yamada T., Mizuno A., Matsumoto K., Shima K., A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat. Mammalian Genome 1998 9 10 794 798 2-s2.0-7344251895 10.1007/s003359900869
39. Choi R., Kim B. H., Naowaboot J., Lee M. Y., Hyun M. R., Cho E. J., Lee E. S., Lee E. Y., Yang Y. C., Chung C. H., Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes. Experimental and Molecular Medicine 2011 43 12 676 683 2-s2.0-84855181872 10.3858/emm.2011.43.12.078
40. Li P., Zhang H., Burczynski F. J., Gong Y., Choy P., Sha H., Li J., Attenuation of diabetic nephropathy in Otsuka long-evans Tokushima fatty (OLETF) rats with a combination of Chinese herbs (tangshen formula). Evidence-Based Complementary and Alternative Medicine 2011 2011 8 2-s2.0-79952179765 10.1155/2011/613737 613737
41. Phillips A. O., Baboolal K., Riley S., Gröne H., Janssen U., Steadman R., Williams J., Floege J., Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of non-insulin-dependent diabetes mellitus. American Journal of Kidney Diseases 2001 37 2 400 410 2-s2.0-0035150875
42. Riley S. G., Evans R. A., Davies M., Floege J., Phillips A. O., Goto-Kakizaki rat is protected from proteinuria after induction of anti-Thy1 nephritis. American Journal of Kidney Diseases 2002 39 5 985 1000 2-s2.0-0036240272 10.1053/ajkd.2002.32772
43. Riley S. G., Steadman R., Williams J. D., Floege J., Phillips A. O., Augmentation of kidney injury by basic fibroblast growth factor or platelet-derived growth factor does not induce progressive diabetic nephropathy in the Goto Kakizaki model of non-insulin-dependent diabetes. Journal of Laboratory and Clinical Medicine 1999 134 3 304 312 2-s2.0-0033198789 10.1016/S0022-2143(99)90211-1
44. Sato N., Komatsu K., Kurumatani H., Late onset of diabetic nephropathy in spontaneously diabetic GK rats. American Journal of Nephrology 2003 23 5 334 342 2-s2.0-0141569622 10.1159/000072915
45. Yamamoto Y., Kato I., Doi T., Yonekura H., Ohashi S., Takeuchi M., Watanabe T., Yamagishi S., Sakurai S., Takasawa S., Okamoto H., Yamamoto H., Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. Journal of Clinical Investigation 2001 108 2 261 268 2-s2.0-0034947508 10.1172/JCI200111771
46. Chua S. C. Jr., Chung W. K., Wu-Peng X. S., Zhang Y., Liu S., Tartaglia L., Leibel R. L., Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996 271 5251 994 996 2-s2.0-0030028959
47. Clee S. M., Nadler S. T., Attie A. D., Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetes. American Journal of Therapeutics 2005 12 6 491 498 2-s2.0-28044456923 10.1097/01.mjt.0000178781.89789.25
48. Hudkins K. L., Pichaiwong W., Wietecha T., Kowalewska J., Banas M. C., Spencer M. W., Mühlfeld A., Koelling M., Pippin J. W., Shankland S. J., Askari B., Rabaglia M. E., Keller M. P., Attie A. D., Alpers C. E., BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. Journal of the American Society of Nephrology 2010 21 9 1533 1542 2-s2.0-77956528157 10.1681/ASN.2009121290
49. Melez K. A., Harrison L. C., Gilliam J. N., Steinberg A. D., Diabetes is associated with autoimmunity in the New Zealand Obese (NZO) mouse. Diabetes 1980 29 10 835 840 2-s2.0-0019297128
50. Lu D., Willard D., Patel I. R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R. P., Wilkison W. O., Cone R. D., Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 1994 371 6500 799 802 2-s2.0-0028112970 10.1038/371799a0
51. Ollmann M. M., Wilson B. D., Yang Y., Kerns J. A., Chen Y., Gantz I., Barsh G. S., Antagonism of Central Melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997 278 5335 135 138 2-s2.0-0030764741 10.1126/science.278.5335.135
52. Okazaki M., Saito Y., Udaka Y., Maruyama M., Murakami H., Ota S., Kikuchi T., Oguchi K., Diabetic nephropathy in KK and KK-Ay mice. Experimental Animals 2002 51 2 191 196 2-s2.0-0036547834 10.1538/expanim.51.191
53. Ninomiya H., Inomata T., Ogihara K., Obstructive uropathy and hydronephrosis in male KK-Ay mice: a report of cases. Journal of Veterinary Medical Science 1999 61 1 53 57 2-s2.0-0032605691
54. Phillips M. S., Liu Q., Hammond H. A., Dugan V., Hey P. J., Caskey C. J., Hess J. F., Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 1996 13 1 18 19 2-s2.0-0030137757
55. Li Y., Qi Y., Kim M. S., Xu K. Z., Huang T. H., Rong X., Murray M., Yamahara J., Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Diabetes/Metabolism Research and Reviews 2008 24 6 498 506 2-s2.0-53349121312 10.1002/dmrr.874
56. Hoshi S., Shu Y., Yoshida F., Inagaki T., Sonoda J., Watanabe T., Nomoto K., Nagata M., Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats. Laboratory Investigation 2002 82 1 25 35 2-s2.0-0036144851
57. Coimbra T. M., Janssen U., Gröne H. J., Ostendorf T., Kunter U., Schmidt H., Brabant G., Floege J., Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes. Kidney International 2000 57 1 167 182 2-s2.0-0033998369 10.1046/j.1523-1755.2000.00836.x
58. Izuhara Y., Sada T., Yanagisawa H., Koike H., Ohtomo S., Dan T., Ito S., Nangaku M., De Strihou C. V. Y., Miyata T., A novel sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats. Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 10 1767 1773 2-s2.0-53449090135 10.1161/ATVBAHA.108.172841
59. Magil A. B., Frohlich J. J., Monocytes and macrophages in focal glomerulosclerosis in Zucker rats. Nephron 1991 59 1 131 138 2-s2.0-0025914497
60. Magil A. B., Tubulointerstitial lesions in young zucker rats. American Journal of Kidney Diseases 1995 25 3 478 485 2-s2.0-0028954655
61. Chen D., Wang M., Development and application of rodent models for type 2 diabetes. Diabetes, Obesity and Metabolism 2005 7 4 307 317 2-s2.0-21444439423 10.1111/j.1463-1326.2004.00392.x
62. Figarola J. L., Loera S., Weng Y., Shanmugam N., Natarajan R., Rahbar S., LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat. Diabetologia 2008 51 5 882 891 2-s2.0-41849106402 10.1007/s00125-008-0935-x
63. Cui W. P., Li B., Bai Y., Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. American Journal of Physiology 2013 304 1 E87 E99 10.1152/ajpendo.00430.2012
64. Zheng S., Noonan W. T., Metreveli N. S., Coventry S., Kralik P. M., Carlson E. C., Epstein P. N., Development of late-stage diabetic nephropathy in OVE26 diabetic mice. Diabetes 2004 53 12 3248 3257 2-s2.0-9444262472 10.2337/diabetes.53.12.3248
65. Xu J., Huang Y., Li F., Zheng S., Epstein P. N., FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria. American Journal of Physiology 2010 299 3 487 494 10.1152/ajprenal.00018.2010
66. Zhao H. J., Wang S., Cheng H., Zhang M., Takahashi T., Fogo A. B., Breyer M. D., Harris R. C., Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. Journal of the American Society of Nephrology 2006 17 10 2664 2669 2-s2.0-33749236623 10.1681/ASN.2006070798
67. Mohan S., Reddick R. L., Musi N., Horn D. A., Yan B., Prihoda T. J., Natarajan M., Abboud-Werner S. L., Diabetic eNOS knockout mice develop distinct macro- and microvascular complications. Laboratory Investigation 2008 88 5 515 528 2-s2.0-42549103718 10.1038/labinvest.2008.23
68. Brosius F. C. III, Alpers C. E., Bottinger E. P., Breyer M. D., Coffman T. M., Gurley S. B., Harris R. C., Kakoki M., Kretzler M., Leiter E. H., Levi M., McIndoe R. A., Sharma K., Smithies O., Susztak K., Takahashi N., Takahashi T., Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology 2009 20 12 2503 2512 2-s2.0-72049119396 10.1681/ASN.2009070721
69. Inagi R., Yamamoto Y., Nangaku M., Usuda N., Okamato H., Kurokawa K., Van Ypersele De Strihou C., Yamamoto H., Miyata T., A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in RAGE/iNOS transgenic mice. Diabetes 2006 55 2 356 366 2-s2.0-33644779814 10.2337/diabetes.55.02.06.db05-0702
70. Maeda M., Yabuki A., Suzuki S., Matsumoto M., Taniguchi K., Nishinakagawa H., Renal lesions in spontaneous insulin-dependent diabetes mellitus in the nonobese diabetic mouse: acute phase of diabetes. Veterinary Pathology 2003 40 2 187 195 2-s2.0-0038207745 10.1354/vp.40-2-187
71. He C.-J., Zheng F., Stitt A., Striker L., Hattori M., Vlassara H., Differential expression of renal AGE-receptor genes in NOD mice: possible role in nonobese diabetic renal disease. Kidney International 2000 58 5 1931 1940 2-s2.0-0033736330 10.1046/j.1523-1755.2000.00365.x
72. Pankewycz O. G., Guan J., Bolton W. K., Gomez A., Benedict J. F., Renal TGF- β regulation in spontaneously diabetic NOD mice with correlations in mesangial cells. Kidney International 1994 46 3 748 758 2-s2.0-0028100437
73. Sharma K., Ziyadeh F. N., Renal hypertrophy is associated with upregulation of TGF- β 1 gene expression in diabetic BB rat and NOD mouse. American Journal of Physiology 1994 267 6, part 2 F1094 F1101 2-s2.0-0028556383
74. Chow F. Y., Nikolic-Paterson D. J., Ozols E., Atkins R. C., Tesch G. H., Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice. Journal of the American Society of Nephrology 2005 16 6 1711 1722 2-s2.0-26944480830 10.1681/ASN.2004070612
75. DeRubertis F. R., Craven P. A., Melhem M. F., Salah E. M., Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 2004 53 3 762 768 2-s2.0-1442349987 10.2337/diabetes.53.3.762
76. Shima K., Shi K., Sano T., Iwami T., Mizuno A., Noma Y., Is exercise training effective in preventing diabetes mellitus in the Otsuka-Long-Evans- Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Metabolism 1993 42 8 971 977 2-s2.0-0027328473 10.1016/0026-0495(93) 90009-D
77. Okauchi N., Mizuno A., Yoshimoto S., Zhu M., Sano T., Shima K., Is caloric restriction effective in preventing diabetes mellitus in the Otsuka Long Evans Tokushima Fatty Rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Diabetes Research and Clinical Practice 1995 27 2 97 106 2-s2.0-0028942913 10.1016/0168-8227(95)01029-D
78. Janssen U., Vassiliadou A., Riley S. G., Phillips A. O., Floege J., The quest for a model of type II diabetes with nephropathy: the Goto Kakizaki rat. Journal of Nephrology 2004 17 6 769 773 2-s2.0-16644376310
79. Miralles F., Portha B., Early development of beta-cells is impaired in the GK rat model of type 2 diabetes. Diabetes 2001 50 S84 88 2-s2.0-0035256958
80. Velasquez M. T., Kimmel P. L., Michaelis O. E. IV, Animal models of spontaneous diabetic kidney disease. FASEB Journal 1990 4 11 2850 2859 2-s2.0-0025204337
81. Bielschowsky F., Bielschowsky M., The New Zealand strain of obese mice; their response to stilboestrol and to insulin. Australian Journal of Experimental Biology & Medical Science 1956 34 3 181 198
82. Leiter E. H., Reifsnyder P. C., Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes. Diabetes 2004 53 1 S4 S11 2-s2.0-0842263993
83. Reifsnyder P. C., Leiter E. H., Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 2002 51 3 825 832 2-s2.0-0036317545
84. Corsetti J. P., Sparks J. D., Peterson R. G., Smith R. L., Sparks C. E., Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis 2000 148 2 231 241 2-s2.0-0033972763 10.1016/S0021-9150(99)00265-8