Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy

Molecular Medicine Reports

Volumn 4, Issue 6, 2011, Pages 1219-1223

  Xie, Yi Qiang ^a   Wang, Hua ^a   Wu, Yue Ping ^a   Yin, De Hui ^a   Wang, Zhuan Suo ^a   Huang, Yong Hao ^a  

^a HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

Apolipo protein E polymorphism; Insulin resistance; Traditional Chinese medicine syndromes; Type 2 diabetes mellitus macroangiopathy

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; INSULIN;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CHINESE MEDICINE; CONTROLLED STUDY; DIABETIC MICROANGIOPATHY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; DRYNESS HEAT; FEMALE; GENOTYPE; HEAT; HUMAN; HUMAN TISSUE; INSULIN ACTION INDEX; INSULIN RESISTANCE; INSULIN RESISTANCE INDEX; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; QI YIN DEFICIENCY; RATING SCALE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; SYNDROME; TO YIN DEFICIENCY; YIN YANG DEFICIENCY;

AGED; APOLIPOPROTEINS E; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INSULIN RESISTANCE; MALE; MEDICINE, CHINESE TRADITIONAL; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; SYNDROME; YANG DEFICIENCY; YIN DEFICIENCY;

EID: 80053099265     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.546     Document Type: Article

References (23)

1. Mensah GA, Mokdad AH, Ford E, Narayan KM, Giles WH, Vinicor F and Deedwania PC: Obesity, metabolic syndrome, and type 2 diabetes: emerging epidemics and their cardiovascular implications. Cardiol Clin 22: 485-504, 2004. (Pubitemid 39389004)
2. Stolar MW: Defining and achieving treatment success in patients with type 2 diabetes mellitus. Mayo Clin Proc 85: S50-S59, 2010.
3. Stolar MW: Atherosclerosis in diabetes: the role of hyperinsulinemia. Metabolism 37: 1-9, 1988
4. Wang Q: The present situation of TCM treatment for diabetes and its researches. J Tradit Chin Med 23: 67-73, 2003.
5. Ning G, Hong J, Bi Y, Gu W, Zhang Y, Zhang Z, Huang Y, Wang W and Li X: Progress in diabetes research in China. J Diabetes 1: 163-172, 2009.
6. Bruce KD and Hanson MA: The developmental origins, mechanisms, and implications of metabolic syndrome. J Nutr 140: 648-652, 2010.
7. Greenow K, Pearce NJ and Ramji DP: The key role of apolipoprotein E in atherosclerosis. J Mol Med 83: 329-342, 2005. (Pubitemid 41201798)
8. Alberti KG and Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553, 1998. (Pubitemid 28319935)
9. Lan L: Standard for diagnosis and therapeutic effect evaluation of diabetes mellitus by integrative Chinese and Western medicine (draft). Zhongguo Zhong Xi Yi Jie He Za Zhi 25: 94-95, 2005 (in Chinese).
10. Zheng X: TCM New Drug Clinical Research Guidelines. Chinese Medical Science and Technology Press, Beijing, pp1-230, 2002.
11. Davignon J, Gregg RE and Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8: 1-21, 1988. (Pubitemid 18049171)
12. Huang Y: Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases. Curr Opin Lipidol 21: 337-345, 2010.
13. Liang S, Pan M, Geng HH, Chen H, Gu LQ, Qin XT, Qian JJ, Zhu JH and Liu CF: Apolipoprotein E polymorphism in normal Han Chinese population: frequency and effect on lipid parameters. Mol Biol Rep 36: 1251-1256, 2009.
14. Arbones-Mainar JM, Johnson LA, Altenburg MK and Maeda N: Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice. Int J Obes (Lond) 32: 1595-1605, 2008.
15. Thakre TP, Mamtani MR and Kulkarni H: Lack of association of the APOE epsilon 4 allele with the risk of obstructive sleep apnea: meta-analysis and meta-regression. Sleep 32: 1507-1511, 2009.
16. Nieminen T, Kahonen M and Lehtimaki T: The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness. Future Cardiol 2: 179-186, 2006.
17. Song J and Chen G: Discussion about the relationship of apolipoprotein E and gene polymorphism with TCM Phlegm stasis syndrome. J Trad Chin Med 8: 13-15, 2002.
18. Li L, Li X and Song J: Application of matching matrix, factor analysis and cluster analysis in research on Phlegm stasis syndrome characteristics of coronary heart disease patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 25 4: 343-347, 2006 (in Chinese).
19. Mammi C, Pastore D, Lombardo MF, Ferrelli F, Caprio M, Consoli C, Tesauro M, Gatta L, Fini M, Federici M, Sbraccia P, Donadel G, Bellia A, Rosano GM, Fabbri A and Lauro D: Sildenafil reduces insulin-resistance in human endothelial cells. PLoS One 6: e14542, 2011.
20. Hearly B: Endothelial cells dysfunction: an emerging endocrinopa linked to coronary disease. J Am Coll Cardiol 16: 349-356, 1990.
21. Van den Oever IA, Raterman HG, Nurmohamed MT and Simsek S: Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediators Inflamm 2010: 792393, 2010.
22. Lee GT and Cho YD: Regulation of fibronectin levels by agmatine and spermine in mesangial cells under high-glucose conditions. Diabetes Res Clin Pract 66: 119-128, 2004. (Pubitemid 39469338)
23. Marette A: Molecular mechanisms of inflammation in obesity-linked insulin resistance. Int J Obes Relat Metab Disord 27 (Suppl 3): S46-S48, 2003.