A high-fat diet or galanin in the PVN decreases phosphorylation of CREB in the nucleus accumbens

Neuroscience

Volumn 248, Issue , 2013, Pages 61-66

  Bocarsly, M E ^a   Avena, N M ^a,b  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Addiction; CREB; Dependence; High fat diet; Nucleus accumbens; Obesity

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GALANIN; LEPTIN; SODIUM CHLORIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FAT INTAKE; LIPID DIET; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ANIMAL; BLOOD; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LONG EVANS RAT; METABOLISM; PHOSPHORYLATION;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIET, HIGH-FAT; GALANIN; LEPTIN; MALE; NUCLEUS ACCUMBENS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PHOSPHORYLATION; RATS; RATS, LONG-EVANS; TRIGLYCERIDES;

EID: 84880156818     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.05.046     Document Type: Article

References (48)

1. Avena N.M., Bocarsly M.E., Rada P., Kim A., Hoebel B.G. After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance. Physiol Behav 2008, 94:309-315.
2. Avena N.M., Rada P., Hoebel B.G. Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 2008, 32:20-39.
3. Barrot M., Olivier J.D., Perrotti L.I., DiLeone R.J., Berton O., Eisch A.J., Impey S., Storm D.R., Neve R.L., Yin J.C., Zachariou V., Nestler E.J. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A 2002, 99:11435-11440.
4. Barrot M., Wallace D.L., Bolanos C.A., Graham D.L., Perrotti L.I., Neve R.L., Chambliss H., Yin J.C., Nestler E.J. Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens. Proc Natl Acad Sci U S A 2005, 102:8357-8362.
5. Belfer I., Hipp H., Bollettino A., McKnight C., Evans C., Virkkunen M., Albaugh B., Max M.B., Goldman D., Enoch M.A. Alcoholism is associated with GALR3 but not two other galanin receptor genes. Genes Brain Behav 2007, 6:473-481.
6. Berke J.D., Hyman S.E. Addiction, dopamine, and the molecular mechanisms of memory. Neuron 2000, 25:515-532.
7. Bocarsly M.E., Berner L.A., Hoebel B.G., Avena N.M. Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: implications for nutrient-specific food addiction behaviors. Physiol Behav 2011, 104:865-872.
8. Briand L.A., Blendy J.A. Molecular and genetic substrates linking stress and addiction. Brain Res 2010, 1314:219-234.
9. Cao J.L., Vialou V.F., Lobo M.K., Robison A.J., Neve R.L., Cooper D.C., Nestler E.J., Han M.H. Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc Natl Acad Sci U S A 2010, 107:17011-17016.
10. Carlezon W.A., Duman R.S., Nestler E.J. The many faces of CREB. Trends Neurosci 2005, 28:436-445.
11. Carlezon W.A., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J. Regulation of cocaine reward by CREB. Science 1998, 282:2272-2275.
12. Chang G.Q., Karatayev O., Ahsan R., Avena N.M., Lee C., Lewis M.J., Hoebel B.G., Leibowitz S.F. Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides. Alcohol Clin Exp Res 2007, 31:249-259.
13. Colantuoni C., Rada P., McCarthy J., Patten C., Avena N.M., Chadeayne A., Hoebel B.G. Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 2002, 10:478-488.
14. Corwin R.L., Avena N.M., Boggiano M.M. Feeding and reward: perspectives from three rat models of binge eating. Physiol Behav 2011, 104:87-97.
15. Dourmashkin J.T., Chang G.Q., Hill J.O., Gayles E.C., Fried S.K., Leibowitz S.F. Model for predicting and phenotyping at normal weight the long-term propensity for obesity in Sprague-Dawley rats. Physiol Behav 2006, 87:666-678.
16. Edwards S., Graham D.L., Bachtell R.K., Self D.W. Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci 2007, 25:2201-2213.
17. Hawes J.J., Brunzell D.H., Narasimhaiah R., Langel U., Wynick D., Picciotto M.R. Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharmacology 2008, 33:1864-1873.
18. Hawes J.J., Narasimhaiah R., Picciotto M.R. Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. J Neurochem 2006, 96:1160-1168.
19. Holmes F.E., Armenaki A., Iismaa T.P., Einstein E.B., Shine J., Picciotto M.R., Wynick D., Zachariou V. Galanin negatively modulates opiate withdrawal via galanin receptor 1. Psychopharmacology 2012, 220:619-625.
20. Jackson K.J., Chen X., Miles M.F., Harenza J., Damaj M.I. The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence. Neuropsychopharmacology 2011, 36:2339-2348.
21. Karatayev O., Baylan J., Weed V., Chang S., Wynick D., Leibowitz S.F. Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake. Alcohol Clin Exp Res 2010, 34:72-80.
22. Kivinummi T., Kaste K., Rantamaki T., Castren E., Ahtee L. Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice. Neurosci Lett 2011, 491:108-112.
23. Kuteeva E., Hokfelt T., Ogren S.O. Behavioural characterisation of transgenic mice overexpressing galanin under the PDGF-B promoter. Neuropeptides 2005, 39:299-304.
24. Kyrkouli S.E., Stanley B.G., Leibowitz S.F. Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur J Pharmacol 1986, 122:159-160.
25. Kyrkouli S.E., Stanley B.G., Seirafi R.D., Leibowitz S.F. Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain. Peptides 1990, 11:995-1001.
26. Leibowitz S.F. Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis. Neuropeptides 2005, 39:327-332.
27. Leibowitz S.F., Akabayashi A., Wang J. Obesity on a high-fat diet: role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence. J Neurosci 1998, 18:2709-2719.
28. Leibowitz S.F., Avena N.M., Chang G.Q., Karatayev O., Chau D.T., Hoebel B.G. Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Physiol Behav 2003, 79:103-111.
29. Leibowitz S.F., Dourmashkin J.T., Chang G.Q., Hill J.O., Gayles E.C., Fried S.K., Wang J. Acute high-fat diet paradigms link galanin to triglycerides and their transport and metabolism in muscle. Brain Res 2004, 1008:168-178.
30. Morganstern I., Barson J.R., Leibowitz S.F. Regulation of drug and palatable food overconsumption by similar peptide systems. Curr Drug Abuse Rev 2011, 4:163-173.
31. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron 2002, 34:13-25.
32. Parker J.A., Bloom S.R. Hypothalamic neuropeptides and the regulation of appetite. Neuropharmacology 2012, 63:18-30.
33. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, New York.
34. Picciotto M.R. Galanin and addiction. EXS 2010, 102:195-208.
35. Pliakas A.M., Carlson R.R., Neve R.L., Konradi C., Nestler E.J., Carlezon W.A. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci 2001, 21:7397-7403.
36. Rada P., Avena N.M., Leibowitz S.F., Hoebel B.G. Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol 2004, 33:91-97.
37. Rada P., Mark G.P., Hoebel B.G. Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior. Brain Res 1998, 798:1-6.
38. Rubino T., Sala M., Vigano D., Braida D., Castiglioni C., Limonta V., Guidali C., Realini N., Parolaro D. Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats. Neuropsychopharmacology 2007, 32:2036-2045.
39. Schneider E.R., Rada P., Darby R.D., Leibowitz S.F., Hoebel B.G. Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 2007, 31:1858-1865.
40. Sharma S., Fernandes M.F., Fulton S. Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal. Int J Obes (Lond) 2012, [Epub ahead of print].
41. Sharma S., Fulton S. Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. Int J Obes (Lond) 2013, 37:382-389.
42. Shiflett M.W., Mauna J.C., Chipman A.M., Peet E., Thiels E. Appetitive Pavlovian conditioned stimuli increase CREB phosphorylation in the nucleus accumbens. Neurobiol Learn Mem 2009, 92:451-454.
43. Smith B.K., York D.A., Bray G.A. Effects of dietary preference and galanin administration in the paraventricular or amygdaloid nucleus on diet self-selection. Brain Res Bull 1996, 39:149-154.
44. Tempel D.L., Leibowitz K.J., Leibowitz S.F. Effects of PVN galanin on macronutrient selection. Peptides 1988, 9:309-314.
45. Tempel D.L., Leibowitz S.F. Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN. Brain Res Bull 1990, 25:821-825.
46. Volkow N.D., Wang G.J., Fowler J.S., Tomasi D., Baler R. Food and drug reward: overlapping circuits in human obesity and addiction. Curr Top Behav Neurosci 2011, [Epub ahead of print].
47. Zachariou V., Brunzell D.H., Hawes J., Stedman D.R., Bartfai T., Steiner R.A., Wynick D., Langel U., Picciotto M.R. The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A 2003, 100:9028-9033.
48. Zachariou V., Parikh K., Picciotto M.R. Centrally administered galanin blocks morphine place preference in the mouse. Brain Res 1999, 831:33-42.