Galanin negatively modulates opiate withdrawal via galanin receptor 1

Psychopharmacology

Volumn 220, Issue 3, 2012, Pages 619-625

  Holmes, Fiona E ^a   Armenaki, Athena ^b   Iismaa, Tiina P ^c   Einstein, Emily B ^d   Shine, John ^c   Picciotto, Marina R ^d   Wynick, David ^a   Zachariou, Venetia ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF CRETE   (Greece)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Galanin; Galanin receptor 1; Locus coeruleus; Mouse; Opiate; Withdrawal

Indexed keywords

BETA GALACTOSIDASE; GALANIN; GALANIN RECEPTOR 1; MORPHINE; NALOXONE; OPIATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; GALANIN RECEPTOR 1 GENE; GALANIN RECEPTOR 2 GENE; GENE EXPRESSION REGULATION; LOCOMOTION; LOCUS CERULEUS; MALE; MOUSE; NEUROMODULATION; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RECEPTOR GENE; TRANSGENIC MOUSE; UPREGULATION; WITHDRAWAL SYNDROME;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; GALANIN; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; OPIOID-RELATED DISORDERS; RECEPTOR, GALANIN, TYPE 1; RECEPTOR, GALANIN, TYPE 2; RECEPTOR, GALANIN, TYPE 3; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84858447441     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2515-x     Document Type: Article

References (37)

1. Bacon A, Kerr NC, Holmes FE, Gaston K, Wynick D (2007) Characterization of an enhancer region of the galanin gene that directs expression to the dorsal root ganglion and confers responsiveness to axotomy. J Neurosci 27:6573-6580 (Pubitemid 46920372)
2. Brabant C, Kuschpel AS, Picciotto MR (2010) Locomotion and self-administration induced by cocaine in 129/OlaHsd mice lacking galanin. Behav Neurosci 124:828-838
3. Branchek TA, Smith KE, Gerald C, Walker MW (2000) Galanin receptor subtypes. Trends Pharmacol Sci 21:109-117 (Pubitemid 30114326)
4. Burgevin MC, Loquet I, Quarteronet D, Habert-Ortoli E (1995) Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor. J Mol Neurosci 6:33-41
5. Elliott-Hunt CR, Marsh B, Bacon A, Pope R, Vanderplank P, Wynick D (2004) Galanin acts as a neuroprotective factor to the hippocampus. Proc Natl Acad Sci U S A 101:5105-5110 (Pubitemid 38469210)
6. Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux JF (1994) Molecular cloning of a functional human galanin receptor. Proc Natl Acad Sci U S A 91:9780-9783 (Pubitemid 24311891)
7. Hawes JJ, Brunzell DH, Wynick D, Zachariou V, Picciotto MR (2005) GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism. J Neurochem 93:1168-1176 (Pubitemid 40776571)
8. Hawes JJ, Narasimhaiah R, Picciotto MR (2006) Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phos-phorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures. J Neurochem 96:1160-1168
9. Hawes JJ, Brunzell DH, Narasimhaiah R, Langel U, Wynick D, Picciotto MR (2008) Galanin protects against behavioral and neurochemical correlates of opiate reward. Neuropsychopharma-cology 33:1864-1873 (Pubitemid 351832595)
10. Hobson SA, Holmes FE, Kerr NC, Pope RJ, Wynick D (2006) Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. J Neurochem 99:1000-1010 (Pubitemid 44583456)
11. Jacoby AS, Hort YJ, Constantinescu G, Shine J, Iismaa TP (2002) Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity. Brain Res Mol Brain Res 107:195-200 (Pubitemid 35335538)
12. Kehr J, Yoshitake T, Wang FH, Wynick D, Holmberg K, Lendahl U, Bartfai T, Yamaguchi M, Hokfelt T, Ogren SO (2001) Micro-dialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice. J Neurosci Methods 109:71-80 (Pubitemid 32727890)
13. Kogan JH, Nestler EJ, Aghajanian GK (1992) Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. Eur J Pharmacol 211:47-53
14. Kolakowski LF Jr et al (1998) Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. J Neurochem 71:2239-2251 (Pubitemid 28531233)
15. Koob GF, Le MM (2008) Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philos Trans R Soc Lond B Biol Sci 363:3113-3123
16. Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuro-psychopharmacology 35:217-238
17. Kuteeva E, Hokfelt T, Ogren SO (2005) Behavioural characterisation of transgenic mice overexpressing galanin under the PDGF-B promoter. Neuropeptides 39:299-304 (Pubitemid 40804601)
18. McClung CA, Nestler EJ, Zachariou V (2005) Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J Neurosci 25:6005-6015 (Pubitemid 40911432)
19. Melander T, Hokfelt T, Rokaeus A (1986) Distribution of galanin-like immunoreactivity in the rat central nervous system. J Comp Neurol 248:475-517 (Pubitemid 16073027)
20. Mennicken F, Hoffert C, Pelletier M, Ahmad S, O Donnell D (2002) Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system. J Chem Neuroanat 24:257-268 (Pubitemid 35291193)
21. Narasimhaiah R, Kamens HM, Picciotto MR (2009) Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. Psychopharmacology (Berl) 204:95-102
22. O'donnell D, Ahmad S, Wahlestedt C, Walker P (1999) Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. J Comp Neurol 409:469-481 (Pubitemid 29262256)
23. Picciotto MR (2008) Galanin and addiction. Cell Mol Life Sci 65:1872-1879
24. Picciotto MR, Brabant C, Einstein EB, Kamens HM, Neugebauer NM (2010) Effects of galanin on monoaminergic systems and HPA axis: potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Res 1314:206-218
25. Pieribone VA, Xu ZQ, Zhang X, Grillner S, Bartfai T, Hokfelt T (1995) Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience 64:861-874
26. Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 10:2308-2317
27. Seutin V, Verbanck P, Massotte L, Dresse A (1989) Galanin decreases the activity of locus coeruleus neurons in vitro. Eur J Pharmacol 164:373-376 (Pubitemid 19138647)
28. Sevcik J, Finta EP, Illes P (1993) Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with mu-opioid receptors. Eur J Pharmacol 230:223-230 (Pubitemid 23025006)
29. Skofitsch G, Sills MA, Jacobowitz DM (1986) Autoradiographic distribution of 125I-galanin binding sites in the rat central nervous system. Peptides 7:1029-1042 (Pubitemid 17226730)
30. Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA (1998) Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K + channels. J Biol Chem 273:23321-23326 (Pubitemid 28417519)
31. Wang S, He C, Maguire MT, Clemmons AL, Burrier RE, Guzzi MF, Strader CD, Parker EM, Bayne ML (1997) Genomic organization and functional characterization of the mouse GalR1 galanin receptor. FEBS Lett 411:225-230 (Pubitemid 27301459)
32. Xu ZQ, Bartfai T, Langel U, Hokfelt T (1998) Effects of three galanin analogs on the outward current evoked by galanin in locus coeruleus. Ann N Y Acad Sci 863:459-465 (Pubitemid 29047804)
33. Zachariou V, Parikh K, Picciotto MR (1999) Centrally administered galanin blocks morphine place preference in the mouse. Brain Res 831:33-42 (Pubitemid 29336185)
34. Zachariou V, Thome J, Parikh K, Picciotto MR (2000) Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal. Neuropsychopharmacology 23:127-137 (Pubitemid 30406897)
35. Zachariou V, Georgescu D, Kansal L, Merriam P, Picciotto MR (2001) Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism. J Neurochem 76:191-200 (Pubitemid 32044382)
36. Zachariou V, Brunzell DH, Hawes J, Stedman DR, Bartfai T, Steiner RA, Wynick D, Langel U, Picciotto MR (2003) The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A 100:9028-9033 (Pubitemid 36899217)
37. Zambrowicz BP et al (2003) Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A 100:14109-14114 (Pubitemid 37499199)