Anticipated brain molecular aging in major depression

American Journal of Geriatric Psychiatry

Volumn 21, Issue 5, 2013, Pages 450-460

  Douillard Guilloux, Gaëlle ^a   Guilloux, Jean Philippe ^a,c   Lewis, David A ^a,b   Sibille, Etienne ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Aging; Amygdala; BDNF; Brain; Human; Major depression; Microarray; Neuropsychiatric; Post mortem

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADOLESCENT; ADULT; AGING; AMYGDALOID NUCLEUS; ARTICLE; AUTOPSY; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MAJOR DEPRESSION; RISK FACTOR;

ADOLESCENT; ADULT; AGED; AGING; AMYGDALA; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED;

EID: 84880154444     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2013.01.040     Document Type: Article

References (27)

1. Reynolds CF III, Kupfer DJ: Depression and aging: a look to the future. Psychiatr Serv 1999; 50:1167-1172 (Pubitemid 29409966)
2. Steffens DC, Otey E, Alexopoulos GS, et al: Perspectives on depression, mild cognitive impairment, and cognitive decline. Arch Gen Psychiatry 2006; 63:130-138 (Pubitemid 43213874)
3. Lenze EJ, Schulz R, Martire LM, et al: The course of functional decline in older people with persistently elevated depressive symptoms: longitudinal findings from the Cardiovascular Health Study. J Am Geriatr Soc 2005; 53:569-575 (Pubitemid 41623476)
4. Fiske A, Wetherell JL, Gatz M: Depression in older adults. Annu Rev Clin Psychol 2009; 5:363-389
5. McKinney BC, Sibille E: The age-by-disease interaction hypothesis of late-life depression. Am J Geriatr Psychiatry 2013; 21:418-432
6. Alexopoulos GS, Schultz SK, Lebowitz BD: Late-life depression: a model for medical classification. Biol Psychiatry 2005; 58: 283-289 (Pubitemid 41133621)
7. Wolkowitz OM, Reus VI, Mellon SH: Of sound mind and body: depression, disease, and accelerated aging. Dialogues Clin Neurosci 2011; 13:25-39
8. Wolkowitz OM, Epel ES, Reus VI, et al: Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety 2010; 27:327-338
9. Yankner BA, Lu T, Loerch P: The aging brain. Annu Rev Pathol 2008; 3:41-66 (Pubitemid 351488276)
10. Glorioso C, Sibille E: Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog Neurobiol 2011; 93:165-181
11. Erraji-Benchekroun L, Underwood MD, Arango V, et al: Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry 2005; 57:549-558 (Pubitemid 40311991)
12. Lu T, Pan Y, Kao SY, et al: Gene regulation and DNA damage in the ageing human brain. Nature 2004; 429:883-891 (Pubitemid 38843301)
13. Blalock EM, Chen KC, Sharrow K, et al: Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment. J Neurosci 2003; 23: 3807-3819 (Pubitemid 36958487)
14. Lee CK, Klopp RG, Weindruch R, et al: Gene expression profile of aging and its retardation by caloric restriction. Science 1999; 285:1390-1393 (Pubitemid 29411668)
15. Lee CK, Weindruch R, Prolla TA: Gene-expression profile of the ageing brain in mice. Nat Genet 2000; 25:294-297 (Pubitemid 30437315)
16. Blalock EM, Geddes JW, Chen KC, et al: Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA 2004; 101:2173-2178 (Pubitemid 38229034)
17. Miller JA, Horvath S, Geschwind DH: Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci USA 2010; 107:12698-12703
18. Glorioso C, Oh S, Douillard GG, et al: Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism. Neurobiol Dis 2011; 41:279-290
19. Webster MJ, Weickert CS, Herman MM, et al: BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Brain Res Dev Brain Res 2002; 139:139-150 (Pubitemid 35453900)
20. Angelucci F, Brene S, Mathe AA: BDNF in schizophrenia, depression and corresponding animal models. Mol Psychiatry 2005; 10: 345-352
21. Weickert CS, Hyde TM, Lipska BK, et al: Reduced brain derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry 2003; 8:592-610 (Pubitemid 36898018)
22. Guilloux JP, Douillard-Guilloux G, Kota R, et al: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol Psychiatry. September 13, 2011. http://dx.doi.org/10.1038/ mp.2011.113
23. Hashimoto T, Bergen SE, Nguyen QL, et al: Relationship of brainderived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 2005; 25:372-383 (Pubitemid 40105607)
24. Glantz LA, Lewis DA: Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity. Arch Gen. Psychiatry 1997; 54:660-669 (Pubitemid 27306576)
25. Sibille E, Wang Y, Joeyen-Waldorf J, et al: A molecular signature of depression in the amygdala. Am J Psychiatry 2009; 166: 1011-1024
26. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc, B 1995; 57:289-300
27. Sen S, Duman R, Sanacora G: Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008; 64:527-532