Deadly H7N9 influenza virus: A pandemic in the making or a warning lesson?

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 1, 2013, Pages 1-2

  Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; GLUTAMIC ACID; HEMAGGLUTININ; NONSTRUCTURAL PROTEIN 1; OSELTAMIVIR; RNA POLYMERASE; SIALIDASE; SODIUM ION; ZANAMIVIR;

AVIAN INFLUENZA VIRUS; BIRD; CHINA; CHINESE; CLINICAL FEATURE; EDITORIAL; GENE DELETION; H7N9 INFLUENZA A; H7N9 INFLUENZA VIRUS A; HUMAN; INFLUENZA A; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H9N2; INNATE IMMUNITY; MARKET; NONHUMAN; PANDEMIC; PATHOGENICITY; POULTRY; PRIORITY JOURNAL; SPANISH INFLUENZA; VIRUS; VIRUS RESISTANCE; VIRUS VIRULENCE;

CHINA; COMMUNICABLE DISEASES, EMERGING; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERNATIONALITY; PANDEMICS;

EID: 84880148970     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201305-0914ED     Document Type: Editorial

References (16)

1. Kageyama T, Fujisaki S, Takashita E, Xu H, Yamada S, et al. Genetic analysis of novel avianA (H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill 2013;18:20453.
2. World Health Organization. Avian influenza A(H7N9) virus. 2013 [accessed 2013 May 8]. http://www.who.int/influenza/human-animal-interface/influenza-h7n9/ en/index.html
3. Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, et al. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 2013;368:1888-1897.
4. Jie Z, Xie J, He Z, Song Y, Hu Y, Li F, Shen Y, Shi J, He Y, Huang Q, et al. Family outbreak of severe pneumonia induced by H7N9 infection [letter]. Am J Respir Crit Care Med 2013;188:114-115.
5. Wang Y, Zhang Y, Wang H, Zhou Z, Zhou Z, Gu Q, Wu C, Zhu B. Sharing insights and H7N9 patient clinical data [letter]. Am J Respir Crit Care Med 2013;188:115-117.
6. Yang H, Chen LM, Carney PJ, Donis RO, Stevens J. Structures of receptor complexes of a North American H7N2 influenza hemagglutinin with a loop deletion in the receptor binding site. PLoS Pathog 2010;6:e1001081.
7. Senne DA, Panigrahy B, Kawaoka Y, Pearson JE, Süss J, Lipkind M, Kida H, Webster RG. Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis 1996;40:425-437. (Pubitemid 26310993)
8. Matsuoka Y, Swayne DE, Thomas C, Rameix-Welti MA, Naffakh N, Warnes C, Altholtz M, Donis R, Subbarao K. Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice. J Virol 2009;83:4704-4708.
9. Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001;293: 1840-1842. (Pubitemid 32845783)
10. Conenello GM, Zamarin D, Perrone LA, Tumpey T, Palese P. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog 2007;3:1414-1421. (Pubitemid 350085606)
11. Jackson D, Hossain MJ, Hickman D, Perez DR, Lamb RA. A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci USA 2008;105: 4381-4386. (Pubitemid 351754389)
12. Hay AJ, Wolstenholme AJ, Skehel JJ, Smith MH. The molecular basis of the specific anti-influenza action of amantadine. EMBO J 1985;4: 3021-3024.
13. Pinto LH, Holsinger LJ, Lamb RA. Influenza virus M2 protein has ion channel activity. Cell 1992;69:517-528.
14. McKimm-Breschkin JL. Resistance of influenza viruses to neuraminidase inhibitors-a review. Antiviral Res 2000;47:1-17. (Pubitemid 30621392)
15. Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 2012;486:420-428.
16. Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012; 336:1534-1541.