Ketamine-derived designer drug methoxetamine: Metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MS n

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 19, 2013, Pages 6307-6321

  Meyer, Markus R ^a   Bach, Martina ^a   Welter, Jessica ^a   Bovens, Michael ^b   Turcant, Alain ^c   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Forensic Institute   (Switzerland)

^c ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Cytochrome P450; Designer drugs; GC MS; LC MS; Methoxetamine; MXE

Indexed keywords

CYTOCHROME P450; DESIGNER DRUGS; GC-MS; LC-MS; METHOXETAMINE; MXE;

AMINES; BIOMOLECULES; BODY FLUIDS; DESIGN; ENZYMES; KINETIC THEORY; KINETICS; METABOLITES; RATS;

METABOLISM;

2 (3 METHOXYPHENYL) 2 (ETHYLAMINO)CYCLOHEXANONE; 2-(3-METHOXYPHENYL)-2-(ETHYLAMINO)CYCLOHEXANONE; CYCLOHEXANONE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; CYTOCHROME P450; DESIGNER DRUG; DRUG DERIVATIVE; KETAMINE;

ANIMAL; ARTICLE; CHEMISTRY; DRUG DETOXIFICATION; EVALUATION; HUMAN; KINETICS; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; RAT; URINE; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; CYCLOHEXANONES; CYCLOHEXYLAMINES; CYTOCHROME P-450 ENZYME SYSTEM; DESIGNER DRUGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; KETAMINE; KINETICS; MALE; METABOLIC DETOXICATION, DRUG; RATS; RATS, WISTAR;

RATTUS;

EID: 84880134735     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7051-6     Document Type: Article

References (36)

1. Hofer KE, Grager B, Muller DM, Rauber-Luthy C, Kupferschmidt H, Rentsch KM, Ceschi A (2012) Ann Emerg Med 60:97-99
2. Archer JR, Dargan PI, Hudson S, Wood DM (2013) QJM 106:147-152
3. Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, Corkery J, Trincas G, Deluca P, Davey Z, Blaszko U, Demetrovics Z, Moskalewicz J, Enea A, di Melchiorre G, Mervo B, di Furia L, Farre M, Flesland L, Pasinetti M, Pezzolesi C, Pisarska A, Shapiro H, Siemann H, Skutle A, Enea A, di Melchiorre G, Sferrazza E, Torrens M, van der Kreeft P, Zummo D, Scherbaum N (2012) Hum Psychopharmacol 27:145-149
4. Coppola M, Mondola R (2012) Med. Hypotheses 79:504-507
5. Hill SL, Harbon SC, Coulson J, Cooper GA, Jackson G, Lupton DJ, Vale JA, and Thomas SH (2013) Emerg Med J (in press)
6. Rosenbaum CD, Carreiro SP, Babu KM (2012) J Med Toxicol 8:15-32
7. The Guardian (2012) The Guardian. http://www.guardian.co.uk/society/2012/ mar/28/legal-high-drug-methoxetamine-banned. Accessed 26 Feb 2013
8. Bundesinstitut für Arzneimittel und Medizinprodukte (2012). http://www.bfarm.de/DE/Bundesopiumstelle/BtM/sachverst/Protokolle/Ergebnisse-39. html. Accessed Feb 2013 2606
9. Wikstrom M, Thelander G, Dahlgren M, Kronstrand R (2013) J Anal Toxicol 37:43-46
10. Wood DM, Davies S, Puchnarewicz M, Johnston A, Dargan PI (2012) Eur J Clin Pharmacol 68:853-856
11. Misselbrook GP, Hamilton EJ (2012) Acute Med 11:157-160
12. Sein AJ, Wiergowski M, Barwina M, Kaletha K (2012) Przegl Lek 69:609-610
13. Shields JE, Dargan PI, Wood DM, Puchnarewicz M, Davies S, Waring WS (2012) Clin Toxicol (Phila) 50:438-440
14. Westwell AD, Hutchings A, and Caldicott DG (2013) Drug Test Anal (in press)
15. Welter J, Meyer MR, Wolf E, Weinmann W, Kavanagh P, and Maurer HH (2013) Anal Bioanal Chem. doi 10.1007/s00216-013-6741-4
16. Maurer HH, Pfleger K, Weber AA (2011) Mass spectral and GC data of drugs, poisons, pesticides, pollutants and their metabolites. Wiley, Weinheim
17. Ewald AH, Ehlers D, Maurer HH (2008) Anal Bioanal Chem 390:1837-1842
18. Maurer HH, Pfleger K, Weber AA (2011) Mass spectral library of drugs, poisons, pesticides, pollutants and their metabolites. Wiley, Weinheim
19. Meyer MR, Peters FT, Maurer HH (2010) Clin Chem 56:575-584
20. Wissenbach DK, Meyer MR, Remane D, Weber AA, Maurer HH (2011) Anal Bioanal Chem 400:79-88
21. Meyer MR, Vollmar C, Schwaninger AE, Maurer HH (2012) J Mass Spectrom 47:253-262
22. Schwaninger AE, Meyer MR, Maurer HH (2011) Drug Metab. Dispos 39:1998-2002
23. Obach RS, Reed-Hagen AE (2002) Drug Metab Dispos 30:831-837
24. Crespi CL, Miller VP (1999) Pharmacol Ther 84:121-131
25. Venkatakrishnan K, von Moltke LL, Court MH, Harmatz JS, Crespi CL, Greenblatt DJ (2000) Drug Metab. Dispos 28:1493-1504
26. Grime K, Riley RJ (2006) Curr. Drug Metab 7:251-264
27. Hays PA, Casale JF, Berrier AL (2012) Microgram J 9:3-17
28. McLafferty FW, Turecek F (1993) Interpretation of mass spectra. University Science Books, Mill Valley, CA
29. Smith RM, Busch KL (1999) Understanding mass spectra - a basic approach. Wiley, New York (NY)
30. de Zeeuw RA, Franke JP, Maurer HH, Pfleger K (1992) Gas chromatographic retention indices of toxicologically relevant substances and their metabolites (Report of the DFG commission for clinical toxicological analysis, special issue of the TIAFT bulletin). VCH Publishers, Weinheim
31. McLafferty FW (2011) Wiley registry of mass spectral data 9th edition with NIST 2011 spectral data. Wiley, New York
32. Sharma V, McNeill JH (2009) Br J Pharmacol 157:907-921
33. Maurer HH, Pfleger K, Weber AA (2013) Mass spectral and GC data of drugs, poisons, pesticides, pollutants and their metabolites. Wiley, Weinheim
34. Maurer HH, Pfleger K, Weber AA (2014) Mass spectral library of drugs, poisons, pesticides, pollutants and their metabolites. Wiley, Weinheim
35. Wissenbach DK, Meyer MR, Remane D, Philipp AA, Weber AA, Maurer HH (2011) Anal Bioanal Chem 400:3481-3489
36. Desta Z, Moaddel R, Ogburn ET, Xu C, Ramamoorthy A, Venkata SL, Sanghvi M, Goldberg ME, Torjman MC, Wainer IW (2012) Xenobiotica 42:1076-1087