Studying the effect of lipid chain length on the precipitation of a poorly water soluble drug from self-emulsifying drug delivery system on dispersion into aqueous medium

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 8, 2013, Pages 1134-1144

  Prasad, Dev ^a   Chauhan, Harsh ^b   Atef, Eman ^a  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b CREIGHTON UNIVERSITY   (United States)

Author keywords

drug and lipid interaction; indomethacin; precipitation inhibition; self emulsifying drug delivery system (SEDDS)

Indexed keywords

CAPRYOL; CASTOR OIL; ESTER; EXCIPIENT; INDOMETACIN; LABRASOL; LAUROGLYCOL; LIPID; PEGLICOL 5 OLEATE; SOLVENT; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL INTERACTION; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; PHYSICAL CHEMISTRY; PRECIPITATION; SELF EMULSIFYING DRUG DELIVERY SYSTEM;

DRUG AND LIPID INTERACTION; INDOMETHACIN; PRECIPITATION INHIBITION; SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS);

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; EMULSIONS; INDOMETHACIN; LIPIDS; MOLECULAR STRUCTURE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; WATER;

EID: 84880133796     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12077     Document Type: Article

References (33)

1. Baum RM,. Combinatorial approaches provide fresh leads for medicinal chemistry. Chem Eng News 1994; 72: 20-26.
2. Lipinski CA, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997; 23: 3-25.
3. Li P, Zhao L,. Developing early formulations: practice and perspective. Int J Pharm 2007; 341: 1-19.
4. Serajuddin ATM,. Salt formation to improve drug solubility. Adv Drug Deliv Rev 2007; 59: 603-616.
5. Serajuddln ATM,. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 1999; 88: 1058-1066.
6. Pouton CW,. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997; 25: 47-58.
7. Constantinides PP,. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995; 12: 1561-1572.
8. Charman WN,. Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts. J Pharm Sci 2000; 89: 967-978.
9. Gursoy RN, Benita S,. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004; 58: 173-182.
10. Pouton CW, Porter CJH,. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev 2008; 60: 625-637.
11. Pouton CW,. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci 2000; 11 (Suppl. 2): S93-S98.
12. Kommuru TR, et al. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 2001; 212: 233-246.
13. Khoo SM, et al. Formulation design and bioavailability assessment of lipidic self- emulsifying formulations of halofantrine. Int J Pharm 1998; 167: 155-164.
14. Holm R, et al. Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. Pharm Res 2002; 19: 1354-1361.
15. Atef E, Belmonte AA,. Formulation and in vitro and in vivo characterization of a phenytoin self-emulsifying drug delivery system (SEDDS). Eur J Pharm Sci 2008; 35: 257-263.
16. Odeberg JM, et al. Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine. Eur J Pharm Sci 2003; 20: 375-382.
17. Singh B, et al. Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential. Drug Deliv 2011; 18: 599-612.
18. Yan YD, et al. Enhanced oral bioavailability of curcumin via a solid lipid-based self-emulsifying drug delivery system using a spray-drying technique. Biol Pharm Bull 2011; 34: 1179-1186.
19. Shah AV, Serajuddin AT,. Development of solid self-emulsifying drug delivery system (SEDDS) I: use of poloxamer 188 as both solidifying and emulsifying agent for lipids. Pharm Res 2012; 29: 2817-2832.
20. Gao P, et al. Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption. J Pharm Sci 2009; 98: 516-528.
21. Porter CJH, et al. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev 2008; 60: 673-691.
22. Tang J, et al. Self-emulsifying drug delivery systems: strategy for improving oral delivery of poorly soluble drugs. Curr Drug Ther 2007; 2: 85-93.
23. Pouton CW,. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006; 29 (3-4 Spec. ISS) 278-287.
24. Aceves-Hernandez JM, et al. Indomethacin polymorphs: experimental and conformational analysis. J Pharm Sci 2009; 98: 2448-2463.
25. Cristofol C, et al. Determination of indomethacin residues in poultry by high performance liquid chromatography. J Chromatogr B 1998; 709: 310-314.
26. Porter CJH, Charman WN,. In vitro assessment of oral lipid based formulations. Adv Drug Deliv Rev 2001; 50 (Suppl. 1): S127-S147.
27. Patil P, et al. Formulation of a self-emulsifying system for oral delivery of simvastatin: in vitro and in vivo evalutaion. Acta Pharm 2007; 57: 111-122.
28. Kang BK, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004; 274: 65-73.
29. Bugay DE,. Characterization of the solid-state: spectroscopic techniques. Adv Drug Deliv Rev 2001; 48: 43-65.
30. Taylor LS, Zografi G,. Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions. Pharm Res 1997; 14: 1691-1698.
31. Strachan CJ, et al. A theoretical and spectroscopic study of γ-crystalline and amorphous indometacin. J Pharm Pharmacol 2007; 59: 261-269.
32. Chen X, et al. Reactivity differences of indomethacin solid forms with ammonia gas. J Am Chem Soc 2002; 124: 15012-15019.
33. Masuda K, et al. Solid-state 13C NMR study of indomethacin polymorphism. Int J Pharm 2006; 318: 146-153.