Timing of myocardial TRPM7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization

Circulation

Volumn 128, Issue 2, 2013, Pages 101-114

  Sah, Rajan ^a,b   Mesirca, Pietro ^c,d   Mason, Xenos ^a   Gibson, William ^e   Bates Withers, Christopher ^a   Van Den Boogert, Marjolein ^a   Chaudhuri, Dipayan ^a   Pu, William T ^a   Mangoni, Matteo E ^c,d   Clapham, David E ^a,f  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^d UNIV MONTPELLIER   (France)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

electrophysiology; heart block; hypertrophy; ion channels; myocytes, cardiac; potassium channels

Indexed keywords

HCN4 PROTEIN; HISTONE DEACETYLASE 9; MAGNESIUM ION; POTASSIUM CHANNEL KV1.2; PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; UNCLASSIFIED DRUG; ZINC ION;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; EMBRYO DEVELOPMENT; FEMALE; GENE DELETION; HEART ATRIOVENTRICULAR NODE; HEART BLOCK; HEART DEATH; HEART DEVELOPMENT; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE CONDUCTION; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

ELECTROPHYSIOLOGY; HEART BLOCK; HYPERTROPHY; ION CHANNELS; MYOCYTES, CARDIAC; POTASSIUM CHANNELS;

ACTION POTENTIALS; AGE FACTORS; ANIMALS; GENE DELETION; HEART CONDUCTION SYSTEM; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; TIME FACTORS; TRPM CATION CHANNELS; VENTRICULAR FUNCTION;

EID: 84880091061     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.000768     Document Type: Article

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