Predictors for major wound complications following preoperative radiotherapy and surgery for soft-tissue sarcoma of the extremities and trunk: Importance of tumor proximity to skin surface

Annals of Surgical Oncology

Volumn 20, Issue 5, 2013, Pages 1494-1499

  Baldini, Elizabeth H ^a,b   Lapidus, Michelle R ^a,b   Wang, Qian ^c   Manola, Judith ^b   Orgill, Dennis P ^a   Pomahac, Bohdan ^a   Marcus, Karen J ^a,b   Bertagnolli, Monica M ^a,b   Devlin, Phillip M ^a,b   George, Suzanne ^b   Abraham, John ^d   Ferrone, Marco L ^a,b   Ready, John E ^a,b   Raut, Chandrajit P ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c Beijing Baiao Pharmaceuticals Co Ltd   (China)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARM; ARTICLE; CANCER RADIOTHERAPY; CANCER SURGERY; DIABETES MELLITUS; FISHERMAN; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE COMPLICATION; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RADIATION INJURY; RADICAL RESECTION; SKIN INJURY; SKIN SURFACE; SOFT TISSUE SARCOMA; SPLIT THICKNESS SKIN GRAFT; TRUNK; TUMOR VOLUME; WOUND CLOSURE; WOUND COMPLICATION;

ADULT; AGED; AGED, 80 AND OVER; DIABETES COMPLICATIONS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE COMPLICATIONS; RADIOTHERAPY, ADJUVANT; SARCOMA; SKIN; SKIN TRANSPLANTATION; SOFT TISSUE NEOPLASMS; SURGICAL FLAPS; TORSO; UPPER EXTREMITY; WOUND HEALING; YOUNG ADULT;

EID: 84880077119     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-012-2797-1     Document Type: Article

References (31)

1. Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982;196(3):305-15.
2. Yang JC, Chang AE, Baker AR, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16(1):197-203.
3. Pisters PW, Harrison LB, Leung DH, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14(3):859-68.
4. NCCN. National Comprehensive Cancer Network (NCCN): NCCN clinical practice guidelines in oncology: soft tissue sarcoma. Version 1.2011. Available at: http://www.nccn.org/professionals/physician-gls/f-guidelines.asp.
5. O'Sullivan B, Davis A, Turcotte R, et al. Five-year results of a randomized phase III trial of pre-operative vs post-operative radiotherapy in extremity soft tissue sarcoma. J Clin Oncol. 2004 ASCO Annual Meeting Proceedings 2004;22(14S July 15 Supplement):Abstract 9007.
6. Davis AM, O'Sullivan B, Turcotte R, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75(1):48-53.
7. Stinson SF, DeLaney TF, Greenberg J, et al. Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 1991;21(6):1493-9.
8. Mundt AJ, Awan A, Sibley GS, et al. Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: clinical and radiobiological results. Int J Radiat Oncol Biol Phys. 1995;32(4):977-85.
9. Robinson MH, Spruce L, Eeles R, et al. Limb function following conservation treatment of adult soft tissue sarcoma. Eur J Cancer. 1991;27(12):1567-74.
10. Karasek K, Constine LS, Rosier R. Sarcoma therapy: functional outcome and relationship to treatment parameters. Int J Radiat Oncol Biol Phys. 1992;24(4):651-6.
11. Pollack A, Zagars GK, Goswitz MS, et al. Preoperative vs. postoperative radiotherapy in the treatment of soft tissue sarcomas: a matter of presentation. Int J Radiat Oncol Biol Phys. 1998;42(3):563-72.
12. O'Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002;359(9325):2235-41.
13. Bujko K, Suit HD, Springfield DS, et al. Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gynecol Obstet. 1993;176(2):124-34.
14. Cheng EY, Dusenbery KE, Winters MR, et al. Soft tissue sarcomas: preoperative versus postoperative radiotherapy. J Surg Oncol. 1996;61(2):90-9.
15. Korah MP, Deyrup AT, Monson DK, et al. Anatomic tumor location influences the success of contemporary limb-sparing surgery and radiation among adults with soft tissue sarcomas of the extremities. Int J Radiat Oncol Biol Phys. 2012;82(2):933-9.
16. Cannon CP, Ballo MT, Zagars GK, et al. Complications of combined modality treatment of primary lower extremity soft-tissue sarcomas. Cancer. 2006;107(10):2455-61.
17. Kunisada T, Ngan SY, Powell G, et al. Wound complications following pre-operative radiotherapy for soft tissue sarcoma. Eur J Surg Oncol. 2002;28(1):75-9.
18. Tseng JF, Ballo MT, Langstein HN, et al. The effect of preoperative radiotherapy and reconstructive surgery on wound complications after resection of extremity soft-tissue sarcomas. Ann Surg Oncol. 2006;13(9):1209-15.
19. Peat BG, Bell RS, Davis A, et al. Wound-healing complications after soft-tissue sarcoma surgery. Plast Reconstr Surg. 1994;93(5):980-7.
20. Kim B, Chen YL, Kirsch DG, et al. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. Int J Radiat Oncol Biol Phys. 2010;77(3):843-50.
21. Kuklo TR, Temple HT, Owens BD, et al. Preoperative versus postoperative radiation therapy for soft-tissue sarcomas. Am J Orthop (Belle Mead NJ). 2005;34(2):75-80.
22. Brant TA, Parsons JT, Marcus RB Jr, et al. Preoperative irradiation for soft tissue sarcomas of the trunk and extremities in adults. Int J Radiat Oncol Biol Phys. 1990;19(4):899-906.
23. Mack LA, Crowe PJ, Yang JL, et al. Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma. Ann Surg Oncol. 2005;12(8):646-53.
24. Wang D, Zhang Q, Kirsch DG, et al. RTOG phase II trial of preoperative image guided radiotherapy (IG-RT) for primary soft tissue sarcoma of the extremity: acute toxicity report. Int J Radiat Oncol Biol Phys. 2011;81(2):S117.
25. Cox DR. Analysis of binary data. London: Methuen and Co.; 1970.
26. Hosmer DW. Applied logistic regression. New York: Wiley; 2000.
27. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. JASA. 1958;53(282):457-81.
28. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-29.
29. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341(10):738-46.
30. Dickie CI, Griffin A, Parent A, et al. Phase II study of preoperative intensity modulated radiation therapy for lower limb soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl):S84-S85 [abstract #181].
31. Barwick WJ, Goldberg JA, Scully SP, et al. Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection. Ann Surg. 1992;216(5):591-5.