An Effective Preoperative Three-Dimensional Radiotherapy Target Volume for Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 3, 2010, Pages 843-850

  Kim, BoKyong ^a,b   Chen, Yen Lin E ^a   Kirsch, David G ^a   Goldberg, Saveli I ^a   Kobayashi, Wendy ^a   Kung, Jong Hyun ^a   Wolfgang, John A ^a   Doppke, Karen ^a   Rosenberg, Andrew E ^a   Nielsen, G Petur ^a   Raskin, Kevin A ^a   Springfield, Dempsey S ^a   Schwab, Joseph H ^a   Gebhardt, Mark C ^c   Yoon, Sam S ^a   Hornicek, Francis J ^a   DeLaney, Thomas F ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Dankook University   (South Korea)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Extremity; Local failure; Preoperative radiotherapy; Radiation volume; Soft tissue sarcomas

Indexed keywords

CLINICAL TARGET VOLUMES; COMPUTED TOMOGRAPHY; DISEASE FREE SURVIVAL; DISTANT METASTASIS; FIELD DESIGN; GROSS TUMOR VOLUME; LOCAL CONTROL; LOCAL FAILURE; LOCAL RECURRENCE; OVERALL SURVIVAL; PLANNING TARGET VOLUMES; PREOPERATIVE RADIOTHERAPY; SOFT TISSUE; SOFT TISSUE SARCOMA; TARGET VOLUMES; THREE-DIMENSIONAL (3D);

COMPUTERIZED TOMOGRAPHY; DISEASE CONTROL; GADOLINIUM; PATHOLOGY; RADIOTHERAPY; TARGETS; TUMORS;

THREE DIMENSIONAL;

DACARBAZINE; DOXORUBICIN; GADOLINIUM; IFOSFAMIDE; MESNA;

ADULT; ARTICLE; BRACHYTHERAPY; CANCER CONTROL; CANCER SIZE; CANCER STAGING; CANCER SURGERY; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FRACTURE; HUMAN; INTRAOPERATIVE RADIOTHERAPY; LIMB TUMOR; MAJOR CLINICAL STUDY; MALE; METASTASIS; OVERALL SURVIVAL; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE DISTRIBUTION; RADIATION FIELD; RETROSPECTIVE STUDY; SKIN MANIFESTATION; SOFT TISSUE SARCOMA; TREATMENT FAILURE; TREATMENT PLANNING; WOUND COMPLICATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; EXTREMITIES; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; SARCOMA; SOFT TISSUE NEOPLASMS; TREATMENT FAILURE; TUMOR BURDEN; YOUNG ADULT;

EID: 77952570193     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.06.086     Document Type: Article

References (25)

1. O'Sullivan B., Davis A.M., Turcotte R., et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limb: A randomized trial. Lancet 359 (2002) 2235-2241
2. Davis A.M., O'Sullivan B., Bell R.S., et al. Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma. J Clin Oncol 20 (2002) 4472-4477
3. Davis A.M., O'Sullivan B., Turcotte R., et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol 75 (2005) 48-53
4. Griffin A.M., Euler C.I., Sharpe M.B., et al. Radiation planning comparison for superficial tissue avoidance in radiotherapy for soft tissue sarcoma of the lower extremity. Int J Radiat Oncol Biol Phys 67 (2007) 847-856
5. Alektiar K.M., Hong L., Brennan M.F., et al. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: Preliminary results. Int J Radiat Oncol Biol Phys 68 (2007) 458-464
6. Kraybill W.G., Harris J., Spiro I.J., et al. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol 24 (2006) 619-625
7. DeLaney T.F., Spiro I.J., Suit H.D., et al. Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys 56 (2003) 1117-1127
8. Pisters P.W.T., Patel S.R., Prieto V.G., et al. Phase I{cyrillic, ukrainian} trial of preoperative doxorubicin-based concurrent chemoradiation and surgical resection for localized extremity and body wall soft tissue sarcomas. J Clin Oncol 22 (2004) 3375-3380
9. Hui A.C., Ngan S.Y., Wong K., Powell G., and Choong P.F.M. Preoperative radiotherapy for soft tissue sarcoma: The Peter MacCallum Cancer Center experience. Eur J Surg Oncol 32 (2006) 1159-1164
10. Virkus W.W., Mollabashy A., Reith J.D., et al. Preoperative radiotherapy in the treatment of soft tissue sarcomas. Clin Orthop 397 (2002) 177-189
11. Nijhuis P.H., Pras E., Sleijfer D.T., et al. Long-term results of preoperative intra-arterial doxorubicin combined with neoadjuvant radiotherapy, followed by extensive surgical resection for locally advanced soft tissue sarcomas of the extremities. Radiother Oncol 51 (1999) 15-19
12. Baldini E.H., Goldberg J., Jenner C., et al. Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk. J Clin Oncol 17 (1999) 3252-3259
13. White L.M., Wunder J.S., Bell R.S., et al. Histologic assessment of peritumoral edema in soft tissue sarcoma. Int J Radiat Oncol Biol Phys 61 (2005) 1439-1445
14. Suit H.D., Mankin H.J., Wood W.C., et al. Treatment of the patient with stage M0 soft tissue sarcoma. J Clin Oncol 6 (1988) 854-862
15. Sadoski C, Suit HD, Rosenberg A, Mankin H, Efird J. Preoperative radiation, surgical margins, and local control of extremity sarcomas of soft tissues. J Surg Oncol 993;52:223-230.
16. Eilber F.C., Rosen G., Eckardt J., et al. Treatment-induced pathologic necrosis: A predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas. J Clin Oncol 19 (2001) 3203-3209
17. Tanabe K.K., Pollock R.E., Ellis L.M., et al. Influence of surgical margins on outcome in patients with preoperatively irradiated extremity soft tissue sarcomas. Cancer 73 (1994) 1652-1659
18. Pisters P.W.T., Leung D.H.Y., Woodruff J., Shi W., and Brennan M.F. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 14 (1996) 1679-1689
19. Zagars G.K., Ballo M.T., Pisters P.W.T., et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: An analysis of 1225 patients. Cancer 97 (2003) 2530-2543
20. Kawaguchi N., Ahmed A.R., Matsumoto S., Manabe J., and Matsushita Y. The concept of curative margin in surgery for bone and soft tissue sarcoma. Clin Orthop 419 (2004) 165-172
21. Gerrand C.H., Wunder J.S., Kandel R.A., et al. Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence. J Bone Joint Surg 83 (2001) 1149-1155
22. Fiore M., Riccardo M., Pennacchioli E., et al. Marginal surgery in primary extremity soft tissue sarcoma: Prognostic role of anatomic barrier at closest surgical margin [Abstract]. Connective Tissue Oncology Society 14th Annual Meeting (2008) 37
23. Gitelis S., Thomas R., Templeton A., and Schajowicz F. Characterization of the pseudo-capsule of soft-tissue sarcomas: An experimental study in rats. Clin Orthop 246 (1989) 285-292
24. Manoso M.W., Pratt J., Healey J.H., et al. Infiltrative MRI pattern and incomplete initial surgery compromise local control of myxofibrosarcoma. Clin Orthop Relat Res 450 (2006) 89-94
25. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346