A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20427-20434

  Minogue, Peter J ^a   Beyer, Eric C ^a   Berthoud, Viviana M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCELERATED DEGRADATION; CONGENITAL CATARACT; FUNCTIONAL BEHAVIORS; GAP JUNCTION PLAQUES; INTERCELLULAR COMMUNICATIONS; PROTEASE INHIBITION; PROTEIN DEGRADATION; WILD-TYPE PROTEINS;

AMINO ACIDS; CELL MEMBRANES; ENZYME INHIBITION;

PROTEINS;

BIOTIN; CONNEXIN 50; CYCLOHEXIMIDE; EPOXOMICIN; GAP JUNCTION PROTEIN; MUTANT PROTEIN; MUTANT PROTEIN CX50FS; NEUROBIOTIN; UNCLASSIFIED DRUG;

ARTICLE; CATARACT; CONTROLLED STUDY; DRUG TARGETING; ENDOPLASMIC RETICULUM; FRAMESHIFT MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; UBIQUITINATION; UPREGULATION; WILD TYPE;

CATARACT; CELL JUNCTIONS; CONNEXIN; GAP JUNCTIONS; INTERCELLULAR COMMUNICATION; PROTEASOME;

BIOLOGICAL TRANSPORT; BIOTIN; CATARACT; CELL COMMUNICATION; CONNEXINS; CYCLOHEXIMIDE; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; EYE PROTEINS; GAP JUNCTIONS; HELA CELLS; HUMANS; HYDRAZONES; HYDROXYUREA; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MUTANT PROTEINS; MUTATION; OLIGOPEPTIDES; PROTEASOME INHIBITORS; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITORS; PROTEOLYSIS;

EID: 84880059878     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.452847     Document Type: Article

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